Hisayuki Hashimoto

ハシモトヒサユキ | Hisayuki Hashimoto

Affiliation and department：

Research field (4)： Anatomy , Genomics , Pathobiochemistry , Cardiology

Research keywords (7)：転写因子 , エピジェネティクス , 分子生物学 , 心不全 , 幹細胞 , リプログラミング , 再生医療

Research theme for competitive and other funds (21)：

2023 - 2026 細胞移植療法の最適化に向けた生体内移植細胞の非侵襲的検出技術の開発
2022 - 2025 Dissecting the transcriptional network of organogenesis based on reprogramming factors
2022 - 2023 中胚葉において循環器形成細胞が誘導される分子基盤解明
2021 - 2023 エピゲノム編集による心筋分化転換法の確立
2019 - 2022 Dissecting the cardiogenic network of ZNF281

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Papers (38)：

Jin Komuro, Dai Kusumoto, Hisayuki Hashimoto, Shinsuke Yuasa. Machine learning in cardiology: Clinical application and basic research. Journal of Cardiology. 2023. 82. 2. 128-133
Hidenori Kojima, Taketaro Sadahiro, Naoto Muraoka, Hiroyuki Yamakawa, Hisayuki Hashimoto, Ryota Ishii, Masahiko Gosho, Yuto Abe, Yu Yamada, Koji Nakano, et al. MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes. Stem Cell Reports. 2023. 18. 6. 1274-1283
小室仁, 橋本寿之, 勝木俊臣, 楠本大, 湯浅慎介, 福田恵一. Single cell解析に基づく心不全特異的な線維芽細胞集団を標的とした心不全の新規治療戦略. 心臓. 2022. 54. 12. 1405-1405
Jin Komuro, Yuta Tokuoka, Tomohisa Seki, Dai Kusumoto, Hisayuki Hashimoto, Toshiomi Katsuki, Takahiro Nakamura, Yohei Akiba, Thukaa Kuoka, Mai Kimura, et al. Development of non-bias phenotypic drug screening for cardiomyocyte hypertrophy by image segmentation using deep learning. Biochemical and Biophysical Research Communications. 2022. 632. 181-188
Shogo Ito, Hisayuki Hashimoto, Hiroyuki Yamakawa, Dai Kusumoto, Yohei Akiba, Takahiro Nakamura, Mizuki Momoi, Jin Komuro, Toshiomi Katsuki, Mai Kimura, et al. The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure. Nature communications. 2022. 13. 1. 5409-5409

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MISC (6)：

Hisayuki Hashimoto, Huanyu Zhou, Maria G. Morales, Maria Abad, Rhonda Bassel-Duby, Eric N. Olson. Induction of Cardiac Cell Types by Direct Reprogramming. CIRCULATION RESEARCH. 2016. 119. 12. E168-E168
Hisayuki Hashimoto, Shinsuke Yuasa, Shugo Tohyama, Tomohisa Seki, Toru Egashira, Kojiro Yae, Dai Kusumoto, Masaki Kodaira, Fumiyuki Hattori, Naoto Muraoka, et al. Novel Method 'Fucci' Elucidated the Cardiomyocyte Cell Cycle Dynamics in Various Life Stages. CIRCULATION. 2010. 122. 21
遠山周吾, 村田光繁, 黒川洵子, Fernando Lopez-Redondo, 服部文幸, 水澤美香, 山川裕之, 橋本寿之, 江頭徹, 関朋久, et al. ヒトiPS由来心筋細胞の電気生理学的特性について. 心電図. 2010. 30. Suppl.4. S-4
Toru Egashira, Shinsuke Yuasa, Yohei Ohno, Tomohisa Seki, Hisayuki Hashimoto, Shogo Toyama, Sung H. Yoon, Chen Hao, Tomofumi Tanaka, Fumiyuki Hattori, et al. Generation of Induced Pluripotent Stem Cells in Healthy Volunteers and Patients With Hereditary Heart Disease. CIRCULATION. 2009. 120. 18. S619-S619
Yohei Ohno, Shinsuke Yuasa, Toru Egashira, Tomohisa Seki, Hisayuki Hashimoto, Shugo Toyama, Sung Han Yoon, Takahide Arai, Chen Hao, Tomofumi Tanaka, et al. Molecular Characterization of Induced Pluripotent Stem (iPS) Cell-Derived Cardiomyocytes. CIRCULATION. 2009. 120. 18. S765-S765

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Lectures and oral presentations (17)：

Cardiac Reprogramming Inducer ZNF281 is Indispensable for Heart Development by Interacting with Key Cardiac Transcriptional Factors
(Basic Cardiovascular Sciences Scientific Session 2022 2022)
Cell fate conversion by epigenome editing
(The 5th JCS Council Forum on Basic CardioVascular Research 2021)
Dissecting the Molecular Mechanism of Cardiac Reprogramming by Epigenetic Analysis
(2020)
Synergistic activation of the cardiac enhancer landscape during reprogramming
(European Society of Cardiology 2019)
エピジェネティクス解析を用いた心筋リプログラミングの分子機構の解明
(第40回日本循環制御医学会総会・学術集会 2019)

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Education (3)：

2008 - 2012 Keio University Graduate School of Medicine
2000 - 2006 Keio University School of Medicine
1998 - 2000 慶應義塾高等学校

Work history (10)：

2022/04 - 現在 Keio University School of Medicine Department of Cardiology
2019/10 - 2022/03 Keio University School of Medicine Center for Preventive Medicine
2018/11 - 2019/09 Keio University School of Medicine Department of Emergency and Critical Care Medicine
2015/10 - 2018/10 University of Texas Southwestern Medical Center Department of Molecular Biology Postdoctoral Fellow
2014/04 - 2015/09 平塚市民病院循環器内科医長

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Awards (10)：

2022/07 - American Heart Association Basic Cardiovascular Sciences Scientific Session 2022 Paul Dudley White International Scholar
2022/07 - American Heart Association Basic Cardiovascular Sciences Scientific Session 2022 Outstanding Early Career Investigator Award
2021/03 - 東京都医師会医学研究賞
2020/08 - 日本循環器学会循環器再生医科学賞
2020/04 - Keio University Keio University School of Medicine Alumni Association (Sanshikai) Young Investigator Award

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Association Membership(s) (6)：

日本再生医療学会 , JAPANESE ASSOCIATION FOR ACUTE MEDICINE , 国際心臓研究会 , The Japanese Circulation Society , THE JAPANESE SOCIETY OF INTERNAL MEDICINE , 日本ゲノム編集学会

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