Ikura Teikichi

イクラテイキチ | Ikura Teikichi

Affiliation and department：
Job title： Project Associate Professor

Research field (7)： Bioorganic chemistry , Cell biology , Molecular biology , Systems genomics , Functional biochemistry , Structural biochemistry , Biophysics

Research keywords (13)： functional foods , CRISPR-Cas , Insect Genome Database , Functional design of protein , Vitamin D receptor , X-ray crystallography , protein folding , Alzheimer's disease , Tau protein , Pin1 , FKBP12 , Cyclophilin A , peptide-prolyl isomerase

Research theme for competitive and other funds (15)：

2017 - 2020 Creation of a protease with a catalytic site that is distant from the substrate binding site
2016 - 2018 Application of molecular shielding effect of intrinsically disordered proteins towards development of protein stabilizers
2013 - 2016 Novel methods to inhibit neurofibrillary tangles of tau protein: functional modifications of peptidyl prolyl isomerases
2010 - 2011 プロリン異性化酵素Pin1との相互作用に伴うタウタンパク質の構造転移の研究
2006 - 2007 網羅的変異解析に基づく新規プロリン異性化酵素の発掘と創製

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Papers (81)：

Takeshi Hiromoto, Teikichi Ikura, Eijiro Honjo, Michael Blaber, Ryota Kuroki, Taro Tamada. Creation of Cross-Linked Crystals With Intermolecular Disulfide Bonds Connecting Symmetry-Related Molecules Allows Retention of Tertiary Structure in Different Solvent Conditions. Frontiers in molecular biosciences. 2022. 9. 908394-908394
Masayuki Oda, Tomoki Sano, Yuji O. Kamatari, Yoshito Abe, Teikichi Ikura, Nobutoshi Ito. Structural analysis of hen egg lysozyme refolded after denaturation at acidic pH. The Protein Journal. 2022. 41. 1. 71-78
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, et al. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology. Communications Biology. 2021. 4. 1. 1175-1175
Kanoh Kondo, Teikichi Ikura, Hikari Tanaka, Kyota Fujita, Sumire Takayama, Yuki Yoshioka, Kazuhiko Tagawa, Hidenori Homma, Su Liu, Ryosuke Kawasaki, et al. Hepta-histidine inhibits Tau aggregation. ACS Chemical Neuroscience. 2021. 12. 16. 3015-3027
Takuya Mizukami, Shunta Furuzawa, Satoru G. Itoh, Saho Segawa, Teikichi Ikura, Kunio Ihara, Hisashi Okumura, Heinrich Roder, Kosuke Maki. Energetics and kinetics of substrate analog-coupled staphylococcal nuclease folding revealed by a statistical mechanical approach. Proceedings of the National Academy of Sciences. 2020. 117. 33. 19953-19962

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MISC (28)：

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Books (8)：

タンパク質のアモルファス凝集と溶解性 : 基礎研究からバイオ産業・創薬研究への応用まで
シーエムシー出版 2019 ISBN:9784781313979
Vitamin D hormone
Academic Press, an imprint of Elsevier 2016 ISBN:9780128048245
キーワード : 蛋白質の一生
共立出版 2008 ISBN:9784320056763
化学便覧
丸善 2003 ISBN:4621071386
新世紀における蛋白質科学の進展
共立出版 2002 ISBN:4320055888

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Education (2)：

1988 - 1993 Kyoto University Graduate School of Science
1984 - 1988 Kyoto University Faculty of Science

Professional career (1)：

Doctor of Science (Kyoto University)

Work history (9)：

2022/04 - 現在 Ochanomizu University Institute for Human Life Science Project Associate Professor
2021/04 - 2022/03 Ochanomizu University Institute for Human Life Innovation Project Associate Professor
2012/04 - 2021/03 Tokyo Medical and Dental University Medical Research Institute
2003/04 - 2012/03 Tokyo Medical and Dental University Graduate School of Biomedical Science
2001/12 - 2005/03 科学技術振興事業団(科学技術振興機構) さきがけ研究21「生体分子の形と機能」領域

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Committee career (5)：

2016 - 現在日本生化学会 The Journal of Biochemistry : Advisory Board
2006 - 2008 新世代研究所「生体ナノマシン構造研究会」委員
2005 - 2006 日本蛋白質科学会理事
1997 - 1998 日本物理学会世話人
1991 - 1992 日本生物物理学会学会委員および運営委員

Association Membership(s) (5)：

The Protein Society , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE BIOPHYSICAL SOCIETY OF JAPAN , PROTEIN SCIENCE SOCIETY OF JAPAN

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