Harada Yoichiro

Affiliation and department：
Job title：チームリーダー

Research field (1)： Functional biochemistry

Research keywords (5)： Endoplasmic reticulum , Extracellular vesicles , Exosomes , Carbohydrate metabolism , Glycosylation

Research theme for competitive and other funds (11)：

2019 - 2022 Elucidation of the role of Warburg effect in the secretion of tumor exosomes
2018 - 2021 Construction of A New Paradigm for Diagnosis and Treatment of Atherosclerosis Obliterans
2018 - 2020 Cellular and molecular mechanism of blood sludging/skimming. Causative role of cancer exosomes and their pathophysiological view points
2017 - 2020 Novel therapeutic proposal for DIC/Shock: from Damage-Sensing/-Control to Damage Resolution
2017 - 2020 Establishment of smart-diagnosis&treatment for canine tumor by exosome

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Papers (52)：

Noriko Kanto, Yuki Ohkawa, Masato Kitano, Kento Maeda, Masafumi Shiida, Tatsuya Ono, Fumi Ota, Yasuhiko Kizuka, Kei Kunimasa, Kazumi Nishino, et al. A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2. The Journal of biological chemistry. 2023. 299. 12. 105365-105365
Yuki Ohkawa, Noriko Kanto, Miyako Nakano, Reiko Fujinawa, Yasuhiko Kizuka, Emma Lee Johnson, Yoichiro Harada, Jun-Ichi Tamura, Naoyuki Taniguchi. Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model. The Journal of biological chemistry. 2023. 299. 8. 105052-105052
Yoichiro Harada, Yu Mizote, Takehiro Suzuki, Akiyoshi Hirayama, Satsuki Ikeda, Mikako Nishida, Toru Hiratsuka, Ayaka Ueda, Yusuke Imagawa, Kento Maeda, et al. Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells. eLife. 2023. 12
Naoyuki Taniguchi, Yuki Ohkawa, Kento Maeda, Noriko Kanto, Emma Lee Johnson, Yoichiro Harada. N-glycan branching enzymes involved in cancer, Alzheimer's disease and COPD and future perspectives. Biochemical and Biophysical Research Communications. 2022. 633. 68-71
前田賢人, 原田陽一郎, 大川祐樹, 谷口直之. N-アセチルグルコサミン転移酵素Vは肺がん細胞において抗がん剤ゲフィチニブ耐性を誘導する. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1T02a-05

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MISC (17)：

前田賢人, 原田陽一郎, 大川祐樹, 谷口直之. ゲフィチニブ耐性獲得における糖鎖機能の解明. 日本癌学会総会記事. 2021. 80回. [P11-3]
前田賢人, 原田陽一郎, 大川祐樹, 谷口直之. ゲフィチニブ耐性獲得における糖鎖機能の解明. 日本癌学会総会記事. 2021. 80回. [P11-3]
JOHNSON Emma Lee, JOHNSON Emma Lee, 大川祐樹, 前田賢人, 北野真郷, 北野真郷, 貫戸紀子, 原田陽一郎, 三善英知, 谷口直之. Crosstalk of the immune response in three kinds of C-type lectin receptors expression cells. 日本糖質学会年会要旨集. 2021. 40th
原田陽一郎, 貫戸紀子, 谷口直之. N-glycosylation and its implication in EV-mediated tumor-host interaction. 日本糖質学会年会要旨集. 2021. 40th
Naoyuki Taniguchi, Yuki Ohkawa, Reiko Fujinawa, Noriko Kanto, Yoichiro Harada, Yasuhiko Kizuka. Keratan sulfate disaccharide: specific targeting to langerin and possible applications to COPD. FASEB JOURNAL. 2020. 34

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Education (1)：

Professional career (1)：

Work history (5)：

2019/04 - 現在大阪国際がんセンター研究所糖鎖オンコロジー部チームリーダー
2015/04 - 2019/03 Kagoshima University Systems Biology in Thromboregulation, Project Associate Professor
2010/10 - 2015/03 RIKEN Glycometabolome team Special Research Associate
2007/10 - 2010/09 Stony Brook University Department of Biochemistry and Cell Biology
2007/04 - 2007/09 Nagoya University Laboratory of Animal Cell Function Postdoctoral Fellow

Awards (4)：

2016/09 - 日本糖質学会第35回日本糖質学会奨励賞
2015/10 - GlycoTokyo GlycoTokyo2015 奨励賞
2014/11 - Society for Glycobiology & Japanese Society of Carbohydrate Research 2014 Joint Annual Meeting BBA General Subjects Best Poster Prize
2014/08 - 日本糖質学会第33回日本糖質学会ポスター賞

Association Membership(s) (4)：

日本癌学会 , 日本分子生物学会 , THE JAPANESE BIOCHEMICAL SOCIETY , 日本糖質学会

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