Honda Ryo

ホンダリョウ | Honda Ryo

Affiliation and department：

Research field (3)： Medical biochemistry , Structural biochemistry , Tumor diagnostics and therapeutics

Research keywords (6)： protein science , ras , cancer , amyloid , 神経変性疾患 , 構造に基づく創薬

Research theme for competitive and other funds (8)：

2022 - 2025 4リピートタウオパチーの予防・診断を指向したRT-QUIC法の開発と創薬研究
2022 - 2025 Non-G12C変異型RASを標的とするキメラ型タンパク質の開発
2022 - 2024 がん遺伝子産物RASを阻害する細胞膜透過性タンパク質の開発
2020 - 2023 犬の変性性脊髄症を起こす変異SOD1蛋白質の立体構造解析と治療基盤の構築
2019 - 2022 Development of a new anticancer drug using a protein that has high affinity and specifically binds to mutant Ras

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Papers (31)：

Sora Sakamoto, Yuichi Riku, Teiko Komori Nomura, Akio Kimura, Naoki Yamahara, Kazuki Ohuchi, Mari Yoshida, Yasushi Iwasaki, Takayoshi Shimohata, Masatoshi Inden, et al. Ultrasensitive detection of TDP-43 and amyloid-β protein aggregates using micelle-assisted seed amplification assay. Translational neurodegeneration. 2024. 13. 1. 51-51
Sora Nozaki, Masanori Hijioka, Xiaopeng Wen, Natsumi Iwashita, Junya Namba, Yoshiaki Nomura, Aoi Nakanishi, Soichiro Kitazawa, Ryo Honda, Yuji O. Kamatari, et al. Galantamine suppresses α-synuclein aggregation by inducing autophagy via the activation of α7 nicotinic acetylcholine receptors. Journal of Pharmacological Sciences. 2024
Teiko Komori Nomura, Satoshi Endo, Takuma Kuwano, Kazuya Fukasawa, Shigeo Takashima, Tomoki Todo, Kyoji Furuta, Takuhei Yamamoto, Eiichi Hinoi, Hiroko Koyama, et al. ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo. Scientific reports. 2023. 13. 1. 10757-10757
Kento Wakayama, Shintaro Kimura, Yui Kobatake, Hiroaki Kamishina, Naohito Nishii, Satoshi Takashima, Ryo Honda, Yuji O Kamatari. Molecular Mechanisms of Aggregation of Canine SOD1 E40K Amyloidogenic Mutant Protein. Molecules (Basel, Switzerland). 2022. 28. 1
Tatsushi Nakayama, Ryo Honda, Kazuo Kuwata, Shigeyuki Usui, Bunji Uno. Electrochemical and Mechanistic Study of Superoxide Scavenging by Pyrogallol in N,N-Dimethylformamide through Proton-Coupled Electron Transfer. Electrochem. 2022

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Patents (3)：

Lectures and oral presentations (3)：

Professional career (1)：

Work history (6)：

2023/01 - 現在 One Medicineトランスレーショナルリサーチセンター兼任
2021/12 - 現在岐阜大学大学院連合創薬医療情報研究科准教授
2017/12 - 2021/11 Gifu University United Graduate School of Drug Discovery and Medical Information Sciences Assistant Professor
2015/04 - 2018/03 Gifu University Graduate School of Medicine PhD
2016/04 - 2017/11 日本学術振興会特別研究員(DC1)

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