Shirai Tsuyoshi

Affiliation and department：

Research field (2)： Allergies and connective tissue disease , Gastroenterology

Research keywords (8)： Takayasu arteritis , 潰瘍性大腸炎 , Autoantibody , 抗MDA5抗体陽性皮膚筋炎 , Vasculitis , Cell metabolism , PKM2 , 腸内細菌叢

Research theme for competitive and other funds (5)：

2021 - 2024 共通病態を基盤とした高安動脈炎と潰瘍性大腸炎を包括する新規症候群の検討
2017 - 2020 Development of a new rheumatoid arthritis monitoring method by analysis of anti-CCP antibody-producing B cell repertoire
2018 - 2020 解糖系酵素ピルビン酸キナーゼM2による炎症性疾患の制御
2016 - 2017 新規自己抗体による高安動脈炎の病態解明と臨床応用
2013 - 2015 脳症を呈する膠原病患者における抗EphB2抗体の臨床的・病原的意義の解明

Papers (137)：

Tokio Katakura, Tsuyoshi Shirai. Positron Emission Tomography in Takayasu Arteritis: A Review Including Patterns of Vascular Involvement Across Modalities and Regions. Journal of Clinical Medicine. 2025
Tokio Katakura, Tsuyoshi Shirai, Hiroshi Fujii, Kenta Oka, Yoshihide Asano. Clinical Images: Multiple blisters on the upper and lower extremities in granulomatosis with polyangiitis. ACR Open Rheumatology. 2025
Tomoyuki Mutoh, Soshi Okazaki, Tsuyoshi Shirai, Hiroko Sato, Susumu Ohtsu, Tomonori Ishii, Hiroshi Fujii. Rheumatoid Factor Predicts Long-Term Retention Associated With Effectiveness of Certolizumab Pegol in Patients With Rheumatoid Arthritis: A Two-Center Retrospective Study. International Journal of Rheumatic Diseases. 2025
Kentaro Mori, Tsuyoshi Shirai, Tomoyuki Mutoh, Jun Inoue, Fumiyoshi Fujishima, Satsuki Kubo, Hirofumi Watanabe, Satoko Sato, Mamoru Narita, Yosuke Hoshi, et al. Drug-induced liver injury related to avacopan therapy. Rheumatology. 2024
Tokio Katakura, Tsuyoshi Shirai, Yusho Ishii, Hiroko Sato, Hiroshi Fujii. Refractory skin ulcers and afebrile bacteraemia with Staphylococcus aureus in antimelanoma differentiation-associated gene 5 antibody-positive dermatomyositis: A case report. Modern Rheumatology Case Reports. 2024

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MISC (34)：

角田洋一, 白井剛志, 正宗淳. IBD病態を踏まえた今後の治療ストラテジー抗EPCR抗体価と潰瘍性大腸炎の病態および治療反応性との関連に関する検討. Gastroenterological Endoscopy. 2022. 64. Suppl.2. 2023-2023
町山智章, 白井剛志, 藤田洋子, 鴨川由紀子, 佐藤紘子, 藤井博司, 石井智徳, 張替秀郎. 重症な急速進行性間質性肺炎を合併した抗MDA5抗体陽性皮膚筋炎に対して多剤併用療法が奏効した一例. 日本リウマチ学会北海道・東北支部学術集会抄録集. 2019. 29回. 74-74
李邱平, 白井剛志, 永井泰地, 町山智章, 鴨川由起子, 佐藤紘子, 藤井博司, 石井智徳, 張替秀郎. 後部虚血性視神経症による急性視力障害を来たした小型血管炎の1例. 日本リウマチ学会北海道・東北支部学術集会抄録集. 2019. 29回. 78-78
Tsuyoshi Shirai, Tomoyuki Mutoh, Tomonori Ishii, Hiroshi Fujii, Hideo Harigae. IDENTIFICATION OF ENDOTHELIAL PROTEIN C RECEPTOR AND SCAVENGER RECEPTOR CLASS B TYPE 1 AS MAJOR AUTOANTIGENS IN TAKAYASU ARTERITIS. ANNALS OF THE RHEUMATIC DISEASES. 2019. 78. 437-438
白井剛志, 武藤智之, 藤田洋子, 藤井博司, 石井智徳, 平林泰彦, 張替秀郎. 血管炎(大型血管炎)-3 生物学的製剤を使用した大型血管炎患者の検討. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2019. 63回. 452-452

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Patents (2)：

Lectures and oral presentations (20)：

Serum and genetic biomarkers of Takayasu arteritis-which are truly useful?
(26th Asia-Pacific League of Associations for Rheumatology Congress 2024)
Novel Autoantibodies in Takayasu Arteritis Suggest Gut-vessel Connection in Vascular Inflammation
(The 88th Annual Scientific Meeting of the Japanese Circulation Society 2024)
自己抗体から紐解く疾患の病理形態
(第112回日本病理学会総会 2023)
Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis
(Nature Communications 2020)
Endothelial Protein C Receptor and Scavenger Receptor Class B Type 1 Negatively Regulate Vascular Inflammation and Are Major Autoantigens in Takayasu Arteritis
(American College of Rheumatology Annual Meeting 2019 2019)

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Education (2)：

2008 - 2012 Tohoku University Graduate School of Medicine Department of Hematology & Rheumatology
1999 - 2005 Tohoku University School of Medicine

Professional career (1)：

Work history (8)：

2024/01 - 現在東北大学病院リウマチ膠原病内科講師
2019/10 - 2023/12 Tohoku University Hospital Rheumatology
2016/04 - 2019/09 Tohoku University Graduate School of Medicine
2013/07 - 2016/03 Stanford University Immunology & Rheumatology Post doctoral fellow
2013/02 - 2013/06 東北大学メディカルメガバンク機構助教

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Awards (12)：

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