Yuge Shinya

ユゲシンヤ | Yuge Shinya

Affiliation and department：

Research field (6)： Physiology , Animals: biochemistry, physiology, behavioral science , Zoological sciences , Morphology, anatomy , Marine/Aquatic life sciences , Molecular biology

Research keywords (13)： Physiology , Blood Vessel , Angiogenesis , Imaging , Wound Healing , Cell Mortility , hormone , Guanylin , Vitamin B1 , Comparative Biology , Zebrafish , Salmon , Eel

Research theme for competitive and other funds (5)：

2022 - 2025 Investigation of Regulation of Angiogenesis by Intraluminal Pressure and Its Physiological Significance
2023 - 2024 Investigation of role of intraluminal pressure in physiological and pathological angiogenesis, and development of innovative treatment of angiogenesis related diseases
2019 - 2022 Investigation of roles of pericytes in wound-induced angiogenesis by fluorescence imaging
2017 - 2019 Investigation of mechanisms of wound-induced angiogenesis using our established live-imaging of adult zebrafish
2003 - 2006 Osmoregulatory Functions of a Novel Guanylin Family in Eels

Papers (17)：

Shunichi Nishima, Takeru Kashiwada, Yoshinobu Saito, Shinya Yuge, Tomohiro Ishii, Kuniko Matsuda, Koichiro Kamio, Masahiro Seike, Shigetomo Fukuhara, Akihiko Gemma. Bortezomib induces Rho-dependent hyperpermeability of endothelial cells synergistically with inflammatory mediators. BMC Pulmonary Medicine. 2024. In Press
Shinya Yuge, Tomohiro Ishii, Chikage Noishiki, Shigetomo Fukuhara. Novel regulatory mechanisms underlying angiogenesis during wound healing revealed by fluorescence-based live-imaging in zebrafish. The Journal of Biochemistry. 2023. 174. 1. 5-12
Shinya Yuge, Koichi Nishiyama, Yuichiro Arima, Yasuyuki Hanada, Eri Oguri-Nakamura, Sanshiro Hanada, Tomohiro Ishii, Yuki Wakayama, Urara Hasegawa, Kazuya Tsujita, et al. Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Nature communications. 2022. 13. 1. 2594-2594
Yusuke Nishimura, Tomohiro Ishii, Koji Ando, Shinya Yuge, Hiroyuki Nakajima, Weibin Zhou, Naoki Mochizuki, Shigetomo Fukuhara. Blood Flow Regulates Glomerular Capillary Formation in Zebrafish Pronephros. Kidney360. 2022. 3. 4. 700-713
Shin M, Nozaki T, Idrizi F, Isogai S, Ogasawara K, Ishida K, Yuge S, Roscoe B, Wolfe SA, Fukuhara S, et al. Valves Are a Conserved Feature of the Zebrafish Lymphatic System. Developmental cell. 2019. 51. 3. 374-386

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MISC (8)：

Yuge, S, Ishii, T, Fukuhara, S. Mechanism of angiogenesis regulated by blood flow induced mechanical stimulation during wound healing. Journal of Clinical and Experimental Medicine (Igaku no Ayumi). 2024. 289. 13. 987-991
石井智裕, 弓削進弥, 福原茂朋. 生体イメージングにより解き明かされた創傷治癒における血管新生の制御機構. 生体の科学. 2022. 73. 6. 1-5
弓削進弥, 遠田悦子, 戸山友香, 黄美貴, 加藤卓也, 奈良井朝子. 研究の効率化と生産性の向上. 日本医科大学しあわせキャリア支援センター第3回女性・若手研究者キャリアデザインプロジェクト公開研究報告書. 2022. 21-38
Yuge, S, Nishiyama, K, Fukuhara, S. Introduction of an article: Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Circular (The Japanese Vascular Biology and Medicine Academic Journal). 2022. 18. 21-24
石井智裕, 弓削進弥, 安藤康史, 福原茂朋. ライブイメージングにより血管新生におけるペリサイトの真の機能を解明する. 日本医科大学医学会雑誌. 2022. 18. 1. 70-71

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Books (4)：

Function Control and Disease Mechanism of Blood and Lymphatic Vessels
2022 ISBN:9784759817355
Handbook of Hormones, 2nd edition
Academic Press 2021 ISBN:9780128206492
Handbook of Hormones, 1st edition
Academic Press 2015 ISBN:9780128010280
Eel Physiology
CRC Press 2013 ISBN:9781466598270

Lectures and oral presentations (55)：

生理的・病的な血管新生における内腔圧の役割の解明と血管新生関連疾患に対する革新的治療法の開発
(日本医科大学しあわせキャリア支援センター 2023年度共同研究・研究支援員配置研究成果発表会 2024)
Investigation of processes and regulatory mechanisms of angiogenesis and other life phenomena using fluorescence live imaging in the adult, larval and embryonic zebrafish
(8th "Unique Workshop" (Workshop of Bioscience with Unique Animals & Methods) 2023)
Mechanical regulation of wound angiogenesis in response to intraluminal pressure
(International Symposium on Mechanobiology for Human Health: 8 years progress in The AMED-CREST/PRIME project on mechanobiology 2023)
Novel mechanical regulation of angiogenesis in wound healing: intraluminal pressure controls angiogenesis via TOCA family BAR domain proteins
(The 30th Annual Meeting of the Japanese Vascular Biology and Medicine Organization (Cardiovascular and Metabolic Week [CVMW] 2022) 2022)
Investigation of processes and regulatory mechanisms of angiogenesis in wound healing by using fluorescence live imaging system in adult zebrafish
(8th Zebrafish & Medaka - based Drug Discovery (ZMDD) Society 2022)

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Works (1)：

Trial imaging of angiogenesis in zebrafish embryos by using Nikon new confocal microscope A1/A1R HD25
Yuge, S., Fukuhara, S. and Nikon Instec (Present: Nikon Solutions) 2018 - 2018

Professional career (1)：

Ph. D. (The University of Tokyo)

Work history (6)：

2023/10 - 現在 Institute of Science Tokyo (Tokyo Medical and Dental University) Faculty of Dentistry, and Institute for Liberal Arts (ILA) Part-time Lecturer
2016/04 - 現在 Institute for Advanced Medical Sciences, Nippon Medical School Dept. Mol. Pathophysiol. Assistant Professor
2013/05 - 2016/03 National Cerebral and Cardioavascular Center Research Institute Dept. Cell. Biol. Research Associate
2009/01 - 2013/04 Michigan State University Div. Fish Wildlife, Dept. Agr. Nat. Resrc. Research Associate
2006/10 - 2008/12 University of Missouri at Columbia Radiopharmaceutical Inst., School of Medicine Postdoctoral Fellow

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Committee career (2)：

2023/04 - 現在 The Japanese Vascular Biology and Medicine Organization Subhead of the secretariat
2022/04 - 現在 The Japanese Vascular Biology and Medicine Organization Councilor

Awards (4)：

2023/09 - "Unique Workshop" (Workshop of Bioscience with Unique Animals & Methods) Best Oral Presentation Award Investigation of processes and regulatory mechanisms of angiogenesis and other life phenomena using fluorescence live imaging in the adult, larval and embryonic zebrafish
2023/06 - Association of associate professor and lecturer in Nippon Medical School Second Prize of High Impact Factor Award Research in the article published in Nature Communications (2022)
2022/12 - Nikon Co. / Nikon Solutions Co., Ltd 2022 NIKON JOICO AWARD Live imaging of angiogenesis in a cutaneous wound of adult zebrafish
2017/12 - The Japanese Vascular Biology and Medicine Organization Young Investigators Award 1st prize Deciphering the mechanisms of angiogenesis regulated by intravascular pressure using fluorescence-based live-imaging of zebrafish

Association Membership(s) (6)：

The Japanese Vascular Biology and Medicine Organization , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , JAPAN SOCIETY FOR CELL BIOLOGY , THE ZOOLOGICAL SOCIETY OF JAPAN , JAPAN SOCIETY FOR COMPARATIVE ENDOCRINOLOGY , The Japanese Biochemical Society

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