Masanori Osawa

Research field (2)： Biophysics , Structural biochemistry

Research keywords (6)： membrane protein , translation factor , structural biology , nuclear magnetic resonance , Signal transduction , ion channel

Research theme for competitive and other funds (20)：

2022 - 2025 Elucidation of the mechanism of hepatitis B virus entry and control of infection by entry inhibitors
2021 - 2024 B型肝炎ウイルスの肝細胞侵入・増殖機構の構造基盤と立体構造に基づく創薬
2021 - 2024 電位依存性イオンチャネルの機能構造と構造間遷移機構の解析による動作機構解明
2019 - 2021 14-3-3タンパク質によるリン酸化シグナル経路の熱力学的・構造生物学的基盤
2018 - 2021 Structural analysis of hepatocyte specific entry and replication mechanism of hepatitis B virus

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Papers (86)：

Shimizu Y, Ohta M, Ishida S, Terayama K, Osawa M, Honma T, Ikeda K. AI-driven molecular generation of not-patented pharmaceutical compounds using world open patent data. Journal of Cheminformatics. 2023. 15. 1. 120
Miura M, Sakaue F, Matsuno H, Morita K, Yoshida A, Hara RI, Nishimura R, Nishida Y, Yokogawa M, Osawa M, et al. TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate. FEBS Letters. 2023. 597. 12. 1667-1676
Shimizu Y, Yonezawa T, Bao Y, Sakamoto J, Yokogawa M, Furuya T, Osawa M, Ikeda K. Applying deep learning to iterative screening of medium-sized molecules for protein-protein interaction-targeted drug discovery. Chemical Communications. 2023. Issue 44. 59. 6722-6725
Ikeda K, Maezawa Y, Yonezawa T, Shimizu Y, Tashiro T, Kanai S, Sugaya N, Masuda Y, Inoue N, Niimi T, et al. DLiP-PPI library: An integrated chemical database of small-to-medium-sized molecules targeting protein-protein interactions. Frontiers in Chemistry. 2023. 10. Volume 10
Sagae T, Yokogawa M, Sawazaki R, Ishii Y, Hosoda N, Hoshino S.I, Imai S, Shimada I, Osawa M. Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail. Journal of Biological Chemistry. 2022. 298. 5. 101844-101844

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MISC (7)：

Tsuchiya Y, Yonezawa T, Yamamori Y, Inoura H, Osawa M, Ikeda K, Tomii K. PoSSuM v.3: A Major Expansion of the PoSSuM Database for Finding Similar Binding Sites of Proteins. Journal of Chemical Information and Modeling. 2023. 63. 23. 7578-7587
Osawa Masanori, Mase Yoko, Yokoagawa Mariko, Takeuchi Koh, Shimada Ichio. 2SBP-05 Structural Basis for Regulation of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1) by G Proteins(New Development of Structural Cell Biology in Signal Transduction,Symposium,The 52th Annual Meeting of the Biophysical Society of. Seibutsu Butsuri. 2014. 54. 1
今井駿輔, 大澤匡範, 三田建一郎, 豊永翔, 町山麻子, 上田卓見, 竹内恒, 老木成稔, 嶋田一夫. イオンチャネルの機能に関連した動的構造. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2013. 35th. 54-55
Eiji Kanamori, Shunsuke Igarashi, Masanori Osawa, Yoshifumi Fukunishi, Ichio Shimada, Haruki Nakamura. Structure determination of a protein assembly by amino acid selective cross-saturation. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2011. 79. 1. 179-190
吉浦知絵, 幸福裕, 上田卓見, 間瀬瑶子, 横川真梨子, 大澤匡範, 寺島裕也, 松島綱治, 嶋田一夫. 脂質二重膜中に再構成したCCR5とリガンド間相互作用に関するNMR解析. 日本蛋白質科学会年会プログラム・要旨集. 2010. 10th. 162

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Books (7)：

Peptide Toxins Targeting K<sub>V</sub> Channels
Springer Nature 2021
Nuclear magnetic resonance approaches for characterizing protein-protein interactions
Methods in Molecular Biology 2018
【試料分析講座】「蛋白質の分析」
分析化学会(丸善) 2012
分子細胞生物学辞典 (第2版)
東京化学同人 2008
実験医学別冊「生命科学のための機器分析実験ハンドブック」
羊土社 2007

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Lectures and oral presentations (110)：

Structural mechanism for the acceleration of the Caf1-dependent deadenylation of mRNA by BTG2
(第46回分子生物学会年会 2023)
Structural insights into the inhibitory mechanism of a transcription factor FOXO3a by 14-3-3ζ
(第46回分子生物学会年会 2023)
タンパク質-タンパク質相互作用をターゲットとした感染阻害大環状物質の探索と構造活性相関解析
(第51回構造活性相関シンポジウム 2023)
Inhibitory mechanism of transcription factor FOXO3a by 14-3-3ζ
(第62回NMR討論会 2023)
Structural basis for a novel PPI inhibitor - Keap1 binding obtained by NMR interaction analyses
(第62回NMR討論会 2023)

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Awards (2)：

2016/07 - The organizing committee of International and Interdisciplinary Symposium 2016 Best Poster Award Structural Basis for the Inhibition of Voltage-dependent K+ Channel by Gating Modifier Toxin
2016/04 - NAGASE Science Technology Foundation 長瀬研究振興賞 Development of novel nanodisc that enables solution NMR analyses of membrane protein interactions in the lipid bilayer

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