Rchr
J-GLOBAL ID:201801015394422547   Update date: Oct. 02, 2024

Takayama Ken-ichi

Takayama Ken-ichi
Affiliation and department:
Research field  (1): Pathobiochemistry
Research keywords  (7): dementia ,  Fraility ,  nuclear receptor ,  sex hormone ,  non-coding RNA ,  cancer ,  aging
Research theme for competitive and other funds  (11):
  • 2020 - 2023 Androgen-receptor signals and cell specific epigenetic regulatory mechanisms in elderly diseases
  • 2019 - 2022 進行性前立腺がんにおける転写因子OCT1の治療抵抗性獲得機序の解明とその臨床応用
  • 2017 - 2021 アンドロゲン応答性マイクロRNAを介した前立腺癌悪性化メカニズムの解明
  • 2018 - 2021 エストロゲン・アンドロゲンシグナルによる転移性前立腺癌のプレシジョンメディシン
  • 2017 - 2020 Investigation of epigenetic mechanisms driving resistance to hormone-therapy and their clinical implications in prostate cance
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Papers (108):
  • Kaoru Sato, Ken-ichi Takayama, Yuko Saito, Satoshi Inoue. ERRα and ERRγ coordinate expression of genes associated with Alzheimer’s disease, inhibiting DKK1 to suppress tau phosphorylation. Proceedings of the National Academy of Sciences. 2024. 121. 37
  • Ken-Ichi Takayama, Takashi Suzuki, Kaoru Sato, Yuko Saito, Satoshi Inoue. Cooperative nuclear action of RNA-binding proteins PSF and G3BP2 to sustain neuronal cell viability is decreased in aging and dementia. Aging cell. 2024. e14316
  • Daisuke Obinata, Kenichi Takayama, Mitchell G Lawrence, Daigo Funakoshi, Makoto Hara, Birunthi Niranjan, Linda Teng, Renea A Taylor, Gail P Risbridger, Satoru Takahashi, et al. Patient-derived castration-resistant prostate cancer model revealed CTBP2 upregulation mediated by OCT1 and androgen receptor. BMC cancer. 2024. 24. 1. 554-554
  • Kaoru Sato, Ken-Ichi Takayama, Satoshi Inoue. Stress granule-mediated RNA regulatory mechanism in Alzheimer's disease. Geriatrics & gerontology international. 2024. 24 Suppl 1. 7-14
  • Daisuke Obinata, Kenichi Takayama, Satoshi Inoue, Satoru Takahashi. Exploring androgen receptor signaling pathway in prostate cancer: A path to new discoveries. International journal of urology : official journal of the Japanese Urological Association. 2024
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MISC (88):
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Lectures and oral presentations  (6):
  • 治療抵抗性へ向かう前立腺がん核内転写複合体形成の統合的解析
    (第42回日本分子生物学会年会 2019)
  • [優秀演題賞]ファミリー転写因子による前立腺がん細胞内でのアンドロゲン受容体下流シグナル制御機構
    (第27回ステロイドホルモン学会学術集会 2019)
  • Regulatory mechanisms of gene expression by androgen receptor for prostate cancer progression
    (首都大学東京カンファレンス 2018)
  • 統合的ゲノム解析により同定されたアンドロゲン受容体標的遺伝子COBLL1を介した前立腺癌の悪性化機構の同定
    (第41回 分子生物学会年会 2018)
  • アンドロゲン受容体が制御するタンパク質、非コードRNAを介する新規エピゲノム制御機構の解明
    (第90回 日本内分泌学会学術総会 2017)
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Education (2):
  • 1998 - 2002 University of Tokyo School of Medicine Medicine
  • 1996 - 1998 The University of Tokyo
Professional career (1):
  • 医学博士 (東京大学)
Work history (4):
  • 2020/04 - 現在 Tokyo Metropolitan Institue of Gerontology Department of Systems Aging Science and Medicine Dupity PI
  • 2016/04 - 2020/03 Tokyo Metropolitan Institute of Gerontology Principal Investigator
  • 2013/04 - 2016/03 University of Tokyo Department of Geriatric Medicine Assistant professor
  • 2008/04 - 2014/03 School of Medicine, the University of Tokyo Department of Anti-aging Medicine Medical Doctor
Committee career (8):
  • 2024/07 - 現在 The Japan Society of Andrology director
  • 2021/09 - 現在 日本老年医学会 雑誌編集委員会
  • 2021/04 - 現在 Frontiers in Oncology Editorial Board
  • 2017/04 - 現在 日本アンドロロジー学会 評議員
  • 2017/04 - 現在 日本内分泌学会 評議員
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Awards (11):
  • 2024/03 - Japan Steroid Hormone Society Academic Encouragement Award
  • 2023/03 - 東京都医師会 医学研究奨励賞
  • 2020/01 - The JGS Research Grant Award in Geriatrics and Gerontology
  • 2019/11 - 日本ステロイドホルモン学会 優秀演題賞
  • 2018/11 - Japan Medical Association Research Encouragement Award
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