Research field (3)：
Neurosurgery
, Genomics
, Tumor biology
Research theme for competitive and other funds (4)：
2021 - 2024 Establishment and clinical application of intratumoral heterogeneity analysis in brain tumors
2018 - 2021 Biological mechanisms of IDH-mutated astrocytomas harboring only 19q-loss
2014 - 2017 Genome-wide epigenetic analysis of glioma and glioma stem-like cells
2011 - 2015 Functional analysis of a set of genes related to the molecular targeted therapy resistance in glioblastoma and the development of novel therapeutic strategies
Papers (47)：
Sina Neyazi, Erika Yamazawa, Karoline Hack, Shota Tanaka, Genta Nagae, Catena Kresbach, Takayoshi Umeda, Alicia Eckhardt, Kenji Tatsuno, Lara Pohl, et al. Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation. Acta Neuropathologica. 2024. 147. 1
Ryohei Otani, Masachika Ikegami, Ryoji Yamada, Hirohisa Yajima, Shinji Kawamura, Sakura Shimizu, Shota Tanaka, Shunsaku Takayanagi, Hirokazu Takami, Tatsuro Yamaguchi. PTPN11 variant may be a prognostic indicator of IDH-wildtype glioblastoma in a comprehensive genomic profiling cohort. Journal of neuro-oncology. 2023. 164. 1. 221-229
Ryohei Otani, Daichi Sadato, Ryoji Yamada, Hirohisa Yajima, Shinji Kawamura, Sakura Shimizu, Shota Tanaka, Shunsaku Takayanagi, Hirokazu Takami, Tatsuro Yamaguchi. CHD5 gene variant predicts leptomeningeal metastasis after surgical resection of brain metastases of breast cancer. Journal of neuro-oncology. 2023. 163. 3. 657-662
Taichi Tamura, Masachika Ikegami, Yusuke Kanemasa, Makiko Yomota, Akiko Furusawa, Ryohei Otani, Chiaki Saita, Ichiro Yonese, Tomoko Onishi, Hiroshi Kobayashi, et al. Selection bias due to delayed comprehensive genomic profiling in Japan. Cancer science. 2022. 114. 3. 1015-1025
Ryohei Otani, Akitake Mukasa, Takeo Uzuka, Fumi Higuchi, Hadzki Matsuda, Masashi Nomura, Shota Tanaka, Phyo Kim, Keisuke Ueki. Gene expression profiling of 19q-loss astrocytomas suggest a specific pattern associated with the better prognosis. Journal of Neuro-Oncology. 2021. 154. 2. 221-228
Keisuke Ueki, Ryohei Otani, Akitake Mukasa. IDH-mutated, 19q deleted anaplastic gliomas constitute a subgroup that look like and behave like oligodendrogliomas. CANCER SCIENCE. 2018. 109. 922-922
