Research field (5):
Cell biology
, Molecular biology
, Tumor biology
, Applied biochemistry
, Structural biochemistry
Research keywords (8):
X-ray crystallography
, 転写因子複合体
, TGF-β
, がん
, restriction enzyme
, DNA glycosylase
, DNA repair
, Nuclease
Research theme for competitive and other funds (6):
2020 - 2024 Structural analysis and regulation of transcription factor complexes involved in tumor development and progression.
2017 - 2019 Regulation of the TGF-beta signaling by peptide aptamers
2015 - 2017 Structural and functional analyses for the transcription factor complex in TGF-beta signalling.
2014 - 2017 Structural and functional analyses for the novel restriction enzyme R.PabI and its homologues in pathogenic bacteria.
2010 - 2011 X-ray crystal structure determination of the Iron/Cadmium transporter in plant.
2006 - 2007 ショウジョウバエの脚の分化に関わる転写調節因子の構造解析
Show all
Papers (63):
Ken-Ichi Miyazono, Keiko Kubota, Kenji Takahashi, Masaru Tanokura. Crystal structure and substrate recognition mechanism of the prolyl endoprotease PEP from Aspergillus niger. Biochemical and biophysical research communications. 2022. 591. 76-81
Ken-ichi Miyazono, Delong Wang, Tomoko Ito, Masaru Tanokura. Crystal structure and DNA cleavage mechanism of the restriction DNA glycosylase R.CcoLI from Campylobacter coli. Scientific reports. 2021. 11. 1. 859-859
Ken-ichi Miyazono, Tomoko Ito, Yui Fukatsu, Hikaru Wada, Akira Kurisaki, Masaru Tanokura. Structural basis for transcriptional coactivator recognition by SMAD2 in TGF-β signaling. Science signaling. 2020. 13. 662
Ken-ichi Miyazono, Delong Wang, Tomoko Ito, Masaru Tanokura. Distortion of double-stranded DNA structure by the binding of the restriction DNA glycosylase R.PabI. Nucleic acids research. 2020. 48. 9. 5106-5118
THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN
, American Crystallographic Association
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, PROTEIN SCIENCE SOCIETY OF JAPAN
, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY