Rchr
J-GLOBAL ID:201801015727812020   Update date: Mar. 14, 2025

SHUJI SAI

サイ シュウジ | SHUJI SAI
Affiliation and department:
Job title: Division Chief
Other affiliations (3):
Research field  (1): Metabolism and endocrinology
Research keywords  (3): Steroid resistant leukemia ,  11beta-hydroxysteroid dehydrogenase ,  Glucocorticoid hormone
Research theme for competitive and other funds  (10):
  • 2022 - 2025 小児急性リンパ性白血病におけるステロイドホルモン抵抗性の新たな発症機序の解明
  • 2023 - 細胞内ステロイドホルモン代謝酵素によるステロイドホルモン抵抗性白血病発症機序の解明
  • 2022 - 細胞内ステロイド代謝酵素と解糖系制御によるステロイド抵抗性白血病発症機序の解明
  • 2021 - 2022 ビタミンD欠乏症とステロイドホルモンシグナルによる胎児発育遅延の原因解明
  • 2019 - 2020 成長ホルモン分泌不全症におけるグルココルチコイドホルモン代謝酵素 とメタボリックプロファイルの関連について
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Papers (49):
  • Sai S., Hirabayashi S., Saito Y., Chapman KE, Manabe A. Reciprocal regulation of 11b-HSD1/2 correlates initial glucocorticoids responsiveness in childhood acute lymphoblastic leukemia. HORMONE RESEARCH IN PAEDIATRICS. 2024. 97. 151
  • Shigetoshi Ogiwara, Soichiro Wada, Shuji Sai, Takuya Tamura. Neurological Resilience in Patients With Anorexia Nervosa Following Prolonged Cardiopulmonary Resuscitation. Cureus. 2024. 16. 3. e55429
  • Down-regulation of HSD11B2 is associated with glycolytic metabolism and increased sensitivity to glucocorticoid induced apoptosis in lymphoblastic leukemia. Pediatric Blood & Cancer. 2024. 71. S1. S42-S43
  • Shuji Sai, Soichiro Wada, Shigetoshi Ogiwara, Takuya Tamura, Karen Chapman. Peripheral glucocorticoid metabolism predicts patient severity in pediatric intensive care unit. Archives of Disease in Childhood. 2023. 108. A332-A333
  • Shuji Sai, Soichiro Wada, Shigetoshi Ogiwara, Takuya Tamura, Karen E Chapman. Peripheral Glucocorticoid Metabolism Associated With Patient Severity in the PICU. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2023. 24. 6. e297-e300
more...
MISC (66):
  • 出戸幸恵, 及川純子, 松澤まき, 齋秀二, 上野倫彦, 茂木悠平, 入船秀仁. てんかん発作時に大腿骨頚部骨折をきたしたビタミンD欠乏性くる病・低カルシウム血症の14歳男児例. 日本小児内分泌学会第3回北海道地方会. 2025
  • 七野紀之, 奥村遼, 及川純子, 齋秀二. A 1-year-old boy developed Staphylococcus aureus bacteremia and primary herpes simplex virus infection simultaneously during the treatment course of mild burn injury. 臨床小児医学. 2024. 71. 1-6
  • 齋秀二, 山田大翔, 佐藤精一, CHAPMAN Karen, 高岡晃教. Cytosolic IRF-3/HSD11B2 modulates glucocorticoid sensitivity during influenza infection. 日本内分泌学会雑誌. 2024. 100. 1
  • 實川 美緒花, 上野 倫彦, 長谷山 圭司, 奥村 遼, 荻原 重俊, 和田 宗一郎, 及川 純子, 田村 卓也, 齋 秀二, 浜崎 和朗, et al. COVID-19ワクチン接種後に発症した急性心筋炎の7歳男児例. 日本小児科学会雑誌. 2023. 127. 5. 737-740
  • 波多野智紀, 奥村遼, 及川純子, 田村卓也, 齋秀二. Two cases of autoimmune thyroid disease in girls preceded by dermatologic symptoms. 日本小児内分泌学会学術集会プログラム・抄録集. 2023. 70. 1-6. 45-49
more...
Lectures and oral presentations  (21):
  • グルココルチコイドホルモン代謝と川崎病の治療感受性について
    (第24回北海道川崎病研究会 2025)
  • 細胞内グルココルチコイドホルモン代謝酵素は小児リンパ性白血病の治療感受性と関連する
    (第32回 日本ステロイドホルモン学会学術集会 2025)
  • Expression of intracellular glucocorticoid metabolizing enzymes correlates initial glucocorticoids responsiveness in childhood acute lymphoblastic leukemia
    (The 57th Annual Scientific Meeting of the Japanese Society for Pediatric Endocrinology 2024)
  • Peripheral glucocorticoid metabolism in Kawasaki Disease
    (The University of Texas Medical Branch, Pediatrics Grand Rounds 2024)
  • Cytosolic IRF-3/HSD11B2 modulates glucocorticoid sensitivity during influenza infection
    (The 97th Annual Congress of the Japan Endocrine Society 2024)
more...
Education (4):
  • 2003 - 2009 Hamamatsu University School of Medicine Faculty of Medicine
  • 2004 - 2006 英国エジンバラ大学医学部大学院
  • 1993 - 1999 Hirosaki University School of Medicine
  • 1989 - 1992 静岡県立清水東高等学校理数科
Professional career (1):
  • M.D., Ph.D. (Hamamatsu University School of Medicine/The University of Edinburgh)
Work history (8):
  • 2024 - 現在 Sapporo Medical University School of Medicine Clinical Professor
  • 2022 - 現在 Hokkaido University School of Medicine Professor of Clinical Medicine
  • 2014 - 現在 Institute for Genetic Medicine, Hokkaido University Signaling in Cancer and Immunology Fellow
  • 2013 - 現在 Teine-Keijinkai Hospital Department of Pediatrics Division Chief
  • 2011 - 2013 The Queen’s Medical Research Institute, University of Edinburgh Endocrinology Unit Fellow
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Awards (4):
  • 2023/09 - Friends of Leukemia Research Fund Credit Saison Award Investigation for the role of intracelluar steroid hormone metabolizing enzyme in steroid resistant leukemia
  • 2022/11 - 日本小児内分泌学会 日本小児内分泌学会2022年度未来開拓研究助成 細胞内ステロイド代謝酵素と解糖系制御によるステロイド抵抗性白血病発症機序の解明
  • 2011/03 - The Uehara Memorial Foundation Research Fellowship Investigation for steroid resistant childhood leukemia
  • 2008/06 - The Endocrine Society Travel Grant Awards Differential Induction of 11beta-Hydroxysteroid Dehydrogenase 1 by Dexamethasone in Glucocorticoid Sensitive and Resistant Leukemia Cells
Association Membership(s) (5):
Society for Endocrinology ,  The Japan Endocrine Society ,  THE JAPANESE SOCIETY FOR PEDIATRIC ENDOCRINOLOGY ,  JAPAN PEDIATRIC SOCIETY ,  日本小児血液・がん学会
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