Jun Fang

Affiliation and department：
Job title： Associate Professor

Research field (4)： Nanobioscience , Pharmacology , Pharmaceuticals - analytical and physicochemistry , Tumor diagnostics and therapeutics

Research keywords (6)： CO , Cancer treatment and prevention , ROS and inflammation , EPR effect , DDS , Nanomedicine

Research theme for competitive and other funds (9)：

2019 - 2022 Clinical application of photodynamic therapy using HPMA-ZnPP for gynecologic cancer
2019 - 2022 Augmentation of EPR effect and therapeutic effect of nanomedicine by inhibiting off-targeting delivery
2016 - 2019 Augmentation of EPR effect and therapeutic effect of nanomedicine by improving tumor microenvironment
2013 - 2016 Design and evaluation of the theranostic potential of tumor-targeted polymeric micelle of zinc protoporphyrin
2011 - 2014 蛍光内視鏡をめざした高分子型分子プローブの創製

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Papers (147)：

Waliul Islam, Hiroyasu Tsutsuki, Azizur Rahman, Ayaka Harada, Tianli Zhang, Katsuhiko Ono, Rayhanul Islam, Foysal Hossen, Takuro Niidome, Tomohiro Sawa, et al. Styrene Maleic Acid Polymer-Encapsulated Chlorophyll as a Stable Micellar Nanoprobe for Advanced Anticancer Photodynamic Therapy. ACS Applied Polymer Materials. 2023. 5. 12. 10289-10302
Yingying Cui, Chunyu Guo, Zhengmei Xia, Yanni Xue, Bingdong Song, Weirong Hu, Xue He, Shimin Liang, Yanyan Wei, Cheng Zhang, et al. Exploring the therapeutic potential of a nano micelle containing a carbon monoxide-releasing molecule for metabolic-associated fatty liver disease by modulating hypoxia-inducible factor-1α. Acta biomaterialia. 2023. 169. 500-516
Xuexue Huang, Yi Zhou, Rong Yang, Danlin Li, Jie Hu, Yanni Xue, Yuhui Wan, Jun Fang, Shichen Zhang. Moderating role of mental health literacy on the relationship between bullying victimization during the life course and symptoms of anxiety and depression in Chinese college students. BMC public health. 2023. 23. 1. 1459-1459
Yanni Xue, Daoxu Zhang, Yanyan Wei, Chunyu Guo, Bingdong Song, Yingying Cui, Cheng Zhang, Dexiang Xu, Shichen Zhang, Jun Fang. Polymeric nano-micelle of carbon monoxide donor SMA/CORM2 ameliorates acetaminophen-induced liver injury via suppressing HMGB1/TLR4 signaling pathway. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2023. 184. 106413-106413
Steffen Hackbarth, Shanghui Gao, Vladimír Šubr, Lisheng Lin, Jakob Pohl, Tomáš Etrych, Jun Fang. Singlet Oxygen In Vivo: It Is All about Intensity-Part 2. Journal of personalized medicine. 2023. 13. 5

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MISC (8)：

Bingdong Song, Weirong Hu, Shichen Zhang, Jun Fang. Role of the macrophage and its polarization in liver inflammatory disorders. Current Topics in Pharmacology. 2020. 24. 13-20
江口佳菜未, 方軍, 周建融, 横溝和美, 前田浩. 腫瘍標的性ヒアルロン酸結合型亜鉛プロトポルフィリン(HA-ZnPP)の有用性評価. 日本薬学会年会要旨集. 2016. 136年会. 4. 178-178
Micelles of Zinc Protoporphyrin Conjugated to HPMA Polymer for Imaging and Light-induced Antitumor Effect Based on the EPR Effect Driven Tumor Delivery. 2014. 65. 6. 454-458
GREISH Khaled, IYER Arun K, FANG Jun, MAEDA Hiroshi. Copoly (styrene-maleic acid) (SMA) Micelles : Polymeric Nanocarrier for Versatile Targeted Anticancer Drug Delivery Based on EPR Effect. 2007. 22. 3. 282-282
H Maeda, J Fang, T Sawa, T Akaike. Enhanced chemotherapeutic response of tumor cells by targeted inhibition of heme oxygenase-I in solid tumor. CLINICAL CANCER RESEARCH. 2003. 9. 16. 6073S-6073S

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Books (4)：

PEGylated zinc protoporphyrin: a micelle forming polymeric drug for cancer therapy
In: Sahoo S et al (eds.), Nanotechnology in Health Care, Singapore, Pan Stanford Publisher, 2012
Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effects in solid tumor.
In: Lu Y, Mahato RI (eds.), Pharmacrutical Perspective of Cancers Therapeutics. New York: AAPS-Springer, 2009
Enhanced permeability and retention (EPR) effect and tumor-selective delivery of anticancer drugs.
In V Torchilin (ed.), Delivery of Protein and Peptide Drugs in Cancer. Imperial College Press, London 2006
Factors and mechanism of EPR effect and clinical outlook of SMANCS.
In: R. Han (ed.), Cancer Chemoprevention and Drug Therapy of the New Millenium. People’s Military Medical Press, Beijing, China 2005

Education (3)：

1999 - 2003 Kumamoto University
1995 - 1998 中国医科大学大学院医学研究科外科学専攻修士課程
1989 - 1995 白求恩医科大学(現吉林大学医学部) 臨床医学科

Work history (4)：

2010/04 - 現在 Sojo University
2005/04 - 2010/03 Sojo University
2003/09 - 2005/03 Duke University Medical Center Research Associate
2003/04 - 2003/08 Kumamoto University

Awards (1)：

2020/12 - 崇城大学ベストリサーチアワード

Association Membership(s) (4)：

日本D D S学会評議員 , 日本薬学会 , 日本DDS学会 , 日本癌学会

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