J-GLOBAL ID:201801015771050099   Update date: Jul. 12, 2024

Jun Fang

Jun Fang
Affiliation and department:
Job title: Associate Professor
Research field  (4): Nanobioscience ,  Pharmacology ,  Pharmaceuticals - analytical and physicochemistry ,  Tumor diagnostics and therapeutics
Research keywords  (6): CO ,  Cancer treatment and prevention ,  ROS and inflammation ,  EPR effect ,  DDS ,  Nanomedicine
Research theme for competitive and other funds  (9):
  • 2019 - 2022 Clinical application of photodynamic therapy using HPMA-ZnPP for gynecologic cancer
  • 2019 - 2022 Augmentation of EPR effect and therapeutic effect of nanomedicine by inhibiting off-targeting delivery
  • 2016 - 2019 Augmentation of EPR effect and therapeutic effect of nanomedicine by improving tumor microenvironment
  • 2013 - 2016 Design and evaluation of the theranostic potential of tumor-targeted polymeric micelle of zinc protoporphyrin
  • 2011 - 2014 蛍光内視鏡をめざした高分子型分子プローブの創製
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Papers (144):
  • Waliul Islam, Hiroyasu Tsutsuki, Azizur Rahman, Ayaka Harada, Tianli Zhang, Katsuhiko Ono, Rayhanul Islam, Foysal Hossen, Takuro Niidome, Tomohiro Sawa, et al. Styrene Maleic Acid Polymer-Encapsulated Chlorophyll as a Stable Micellar Nanoprobe for Advanced Anticancer Photodynamic Therapy. ACS Applied Polymer Materials. 2023. 5. 12. 10289-10302
  • Yingying Cui, Chunyu Guo, Zhengmei Xia, Yanni Xue, Bingdong Song, Weirong Hu, Xue He, Shimin Liang, Yanyan Wei, Cheng Zhang, et al. Exploring the therapeutic potential of a nano micelle containing a carbon monoxide-releasing molecule for metabolic-associated fatty liver disease by modulating hypoxia-inducible factor-1α. Acta biomaterialia. 2023. 169. 500-516
  • Xuexue Huang, Yi Zhou, Rong Yang, Danlin Li, Jie Hu, Yanni Xue, Yuhui Wan, Jun Fang, Shichen Zhang. Moderating role of mental health literacy on the relationship between bullying victimization during the life course and symptoms of anxiety and depression in Chinese college students. BMC public health. 2023. 23. 1. 1459-1459
  • Yanni Xue, Daoxu Zhang, Yanyan Wei, Chunyu Guo, Bingdong Song, Yingying Cui, Cheng Zhang, Dexiang Xu, Shichen Zhang, Jun Fang. Polymeric nano-micelle of carbon monoxide donor SMA/CORM2 ameliorates acetaminophen-induced liver injury via suppressing HMGB1/TLR4 signaling pathway. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2023. 184. 106413-106413
  • Steffen Hackbarth, Shanghui Gao, Vladimír Šubr, Lisheng Lin, Jakob Pohl, Tomáš Etrych, Jun Fang. Singlet Oxygen In Vivo: It Is All about Intensity-Part 2. Journal of personalized medicine. 2023. 13. 5
MISC (7):
  • 江口 佳菜未, 方 軍, 周 建融, 横溝 和美, 前田 浩. 腫瘍標的性ヒアルロン酸結合型亜鉛プロトポルフィリン(HA-ZnPP)の有用性評価. 日本薬学会年会要旨集. 2016. 136年会. 4. 178-178
  • Micelles of Zinc Protoporphyrin Conjugated to HPMA Polymer for Imaging and Light-induced Antitumor Effect Based on the EPR Effect Driven Tumor Delivery. 2014. 65. 6. 454-458
  • GREISH Khaled, IYER Arun K, FANG Jun, MAEDA Hiroshi. Copoly (styrene-maleic acid) (SMA) Micelles : Polymeric Nanocarrier for Versatile Targeted Anticancer Drug Delivery Based on EPR Effect. 2007. 22. 3. 282-282
  • H Maeda, J Fang, T Sawa, T Akaike. Enhanced chemotherapeutic response of tumor cells by targeted inhibition of heme oxygenase-I in solid tumor. CLINICAL CANCER RESEARCH. 2003. 9. 16. 6073S-6073S
  • J Fang, T Sawa, S Tanaka, T Akaike, G Khaled, H Maeda. Pegylated zinc protoporphyrin for cancer therapy: An antitumor strategy by targeted inhibition of heme oxygenase-1 in solid tumor. JOURNAL OF CONTROLLED RELEASE. 2003. 91. 1-2. 265-266
Books (4):
  • PEGylated zinc protoporphyrin: a micelle forming polymeric drug for cancer therapy
    In: Sahoo S et al (eds.), Nanotechnology in Health Care, Singapore, Pan Stanford Publisher, 2012
  • Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effects in solid tumor.
    In: Lu Y, Mahato RI (eds.), Pharmacrutical Perspective of Cancers Therapeutics. New York: AAPS-Springer, 2009
  • Enhanced permeability and retention (EPR) effect and tumor-selective delivery of anticancer drugs.
    In V Torchilin (ed.), Delivery of Protein and Peptide Drugs in Cancer. Imperial College Press, London 2006
  • Factors and mechanism of EPR effect and clinical outlook of SMANCS.
    In: R. Han (ed.), Cancer Chemoprevention and Drug Therapy of the New Millenium. People’s Military Medical Press, Beijing, China 2005
Education (3):
  • 1999 - 2003 Kumamoto University
  • 1995 - 1998 中国医科大学 大学院医学研究科外科学専攻修士課程
  • 1989 - 1995 白求恩医科大学(現吉林大学医学部) 臨床医学科
Work history (4):
  • 2010/04 - 現在 Sojo University
  • 2005/04 - 2010/03 Sojo University
  • 2003/09 - 2005/03 Duke University Medical Center Research Associate
  • 2003/04 - 2003/08 Kumamoto University
Awards (1):
  • 2020/12 - 崇城大学 ベストリサーチアワード
Association Membership(s) (4):
日本D D S学会評議員 ,  日本薬学会 ,  日本DDS学会 ,  日本癌学会
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