Yamaoki Yudai

ヤマオキユウダイ | Yamaoki Yudai

Affiliation and department：
Job title：助教
Homepage URL (1)： http://www.iae.kyoto-u.ac.jp/bio/

Research field (4)： Biophysics , Structural biochemistry , Biochemistry , Molecular biochemistry

Research keywords (18)：構造生物学 , 生物物理学 , 核酸化学 , 細胞構造生物学 , NMR , in-cell NMR , 核酸構造 , ダイナミクス , 分子間相互作用 , グアニン四重鎖 , i-motif , RNAアプタマー , リボザイム , DNA複製 , 木質バイオマス , リグニン , アミロイド , 高圧

Research theme for competitive and other funds (8)：

2024 - 2025 分子混雑環境下の核酸の運動性解析
2022 - 2025 細胞内環境下におけるエピゲノム修飾を含む核酸の構造ダイナミクス解析
2019 - 2021 In-cell NMR法を用いたヒト生細胞内核酸の構造安定性および相互作用の評価
2017 - 2019 細胞内外で活性をスイッチする機能性核酸のIn-cell NMR法等を用いた創製
2016 - 2018 Development of functional RNA whose activity of trapping a protein switches on/off for intra- and extracellular conditions

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Papers (21)：

Afaf Eladl*, Yudai Yamaoki*, Keisuke Kamba*, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Shou Waga, Takashi Nagata, Masato Katahira (*: equally contributed). NMR characterization of the structure of the intrinsically disordered region of human origin recognition complex subunit 1, hORC1, and of its interaction with G-quadruplex DNAs. Biochemical and Biophysical Research Communications. 2023. in press
Omar Eladl*, Yudai Yamaoki*, Keiko Kondo, Takashi Nagata, Masato Katahira (*: equally contributed). Complex formation of an RNA aptamer with a part of HIV-1 Tat through induction of base triples in living human cells proved by in-cell NMR. International Journal of Molecular Sciences. 2023. in press. 10. 9069-9069
Yudai Yamaoki, Takashi Nagata, Keiko Kondo, Tomoki Sakamoto, Shohei Takami, Masato Katahira. Shedding light on the base-pair opening dynamics of nucleic acids in living human cells. Nature Communications. 2022. 13. 1. 7143
Omar Eladl*, Yudai Yamaoki*, Keiko Kondo, Takashi Nagata, Masato Katahira (*: equally contributed). Detection of interaction between an RNA aptamer and its target compound in living human cells using 2D in-cell NMR. Chemical Communications. 2022. 59. 1. 102-105
Kohei Miyauchi, Hiroshi Imamura, Yudai Yamaoki, Minoru Kato. Small-angle X-ray scattering data of a guanine-rich DNA derived from the promoter region of c-MYC gene in solution. Data in Brief. 2022. 42. 108285

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MISC (56)：

阪本知樹, 山置佑大, 永田崇, 片平正人. 分子クラウディング環境が三重鎖構造DNAの構造ダイナミクスに与える影響のNMR法を用いた解析. 学術変革領域研究(A)「物質共生」領域会議, 九州大学病院キャンパス. 2023
分子クラウディング環境が三重鎖構造DNAの構造ダイナミクスに与える影響のNMR法を用いた解析. 2023
阪本知樹, 山置佑大, 永田崇, 片平正人. The first detection of the formation of DNA triplex structure in living human cells and an analysis of base pair dynamics under molecular crowding environment. 第103回日本化学会春季年会. 2023
川上愛加, 山置佑大, 近藤敬子, 阪本知樹, 永田崇, 片平正人. Physicochemical analysis of the droplets formed by nucleic acids using NMR spectroscopy. 第45回日本分子生物学会年会. 2022
阪本知樹, 山置佑大, 永田崇, 片平正人. Analysis of base pair opening/closing dynamics of DNA triplex structure under molecular crowding environment using relaxation dispersion experiments. Annual Meeting of the NMR Society of Japan. 2022

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Books (5)：

Experimental Approaches of NMR Spectroscopy -Methodology and Application to Life Science and Material Science 2nd Edition
Springer 2023
生命金属ダイナミクス ~生体内における金属の挙動と制御~
NTS 2021
The First Successful Observation of in-cell NMR Signals of DNA and RNA in Living Human Cells
2019
ヒト生細胞中のDNAおよびRNAのNMRシグナル観測に初めて成功
新学術領域「柔らかな分子系」ニュースレター第54号(平成30年2月号) 2018
カリウムイオンを感知して自律的に自らの活性をスイッチングするRNA アプタマーの開発
新学術領域「柔らかな分子系」ニュースレター第48号(平成29年8月号) 2017

Lectures and oral presentations (6)：

In-cell NMR法によるヒト生細胞内環境下の核酸の構造およびダイナミクスの解析
(第21回若手NMR研究会 2021)
Evaluation of the structure and dynamics of nucleic acids inside the living human cells by in-cell NMR spectroscopy
(The 57th Annual Meeting of the Biophysical Society of Japan 2019)
In-cell NMR法によるヒト細胞内DNAおよびRNAの観測
(第19回若手NMR研究会 2018)
Evaluation of the structural stability and dynamics of nucleic acids inside the living cells by using in-cell NMR spectroscopy
(The 18th Annual Meeting of the Protein Society of Japan 2018)
Development of K+-responsive Tat-binding RNA aptamer and hammerhead ribozyme
(FIBER FUTURE COLLEGE 35 2017)

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Professional career (1)：

博士(エネルギー科学) (京都大学)

Work history (3)：

2020/04 - 現在 Kyoto University Institute of Advanced Energy Assistant professor
2016/02 - 2020/03 Kyoto University Institute of Advanced Energy Postdoctoral fellow
2013/04 - 2015/03 日本学術振興会特別研究員

Committee career (2)：

2022/09 - 第22回若手NMR研究会世話人
2013/06 - 第14回若手NMR研究会世話人

Awards (7)：

2023/03 - 2022年度京都大学エネルギー理工学研究所表彰研究奨励賞
2021/08 - ISMAR-APNMR-NMRSJ-SEST 2021, JEOL RESONANCE Poster Award
2019/09 - The Biophysical Society of Japan Awardees of Early Career Presentation Award
2016/09 - The 43rd International Symposium on Nucleic Acids Chemistry (ISNAC), Outstanding Poster Award
2016/08 - The 27th International Conference on Magnetic Resonance in Biological Systems (ICMRBS), Young Investigator Award

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Association Membership(s) (7)：

日本化学会 , 日本核酸化学会 , PROTEIN SCIENCE SOCIETY OF JAPAN , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN , THE RNA SOCIETY OF JAPAN , THE BIOPHYSICAL SOCIETY OF JAPAN

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