Rchr
J-GLOBAL ID:201801015797548869   Update date: Apr. 22, 2021

Yamashita Tomohiro

ヤマシタ トモヒロ | Yamashita Tomohiro
Affiliation and department:
Homepage URL  (1): http://global.phar.kyushu-u.ac.jp/
Research field  (3): Neuroscience - general ,  Clinical pharmacy ,  Pharmacology
Research keywords  (12): P2X4R ,  microglia ,  Mrgpr ,  GPCR ,  high-throughput screening ,  pharmacology ,  pain ,  itch ,  glia ,  chemical screening ,  drug discovery ,  purinergic receptor
Research theme for competitive and other funds  (10):
  • 2019 - 2024 Elucidation of abnormal functioning of neuronal circuits underlying neuropathic pain and its application for drug discovery
  • 2017 - 2022 グリーンファルマを基盤にした創薬オープンイノベーションの推進
  • 2019 - 2021 制御化合物から紐解くかゆみ伝達におけるMrgprの役割そして創薬への応用
  • 2018 - 2021 P2X4に対する高親和性抗体を利用した痛みを抑制する誘導体化抗体の開発
  • 2017 - 2019 Molecular mechanism and physiological role of mitochondrial DNA degradation by mitophagy
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Papers (19):
  • Tomohiro Yamashita, Sawako Kamikaseda, Aya Tanaka, Hidetoshi Tozaki-Saitoh, Jose M M Caaveiro, Kazuhide Inoue, Makoto Tsuda. New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain. Cells. 2021. 10. 2
  • Makoto Yoritate, Yuki Morita, Manuel Gemander, Masaki Morita, Tomohiro Yamashita, Mikiko Sodeoka, Go Hirai. Correction to "Synthesis of DFGH-Ring Derivatives of Physalins via One-Pot Construction of GH-Ring and Evaluation of Their NF-κB-Inhibitory Activity". Organic letters. 2020
  • Makoto Yoritate, Yuki Morita, Manuel Gemander, Masaki Morita, Tomohiro Yamashita, Mikiko Sodeoka, Go Hirai. Synthesis of DFGH-Ring Derivatives of Physalins via One-Pot Construction of GH-Ring and Evaluation of Their NF-κB-Inhibitory Activity. Organic letters. 2020. 22. 22. 8877-8881
  • Hidetoshi Tozaki-Saitoh, Izumi Sasaki, Tomohiro Yamashita, Masako Hosoi, Takahiro A Kato, Makoto Tsuda. Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors. Journal of pharmacological sciences. 2020. 143. 3. 133-140
  • Ryoko Igarashi, Shun-Ichi Yamashita, Tomohiro Yamashita, Keiichi Inoue, Tomoyuki Fukuda, Takeo Fukuchi, Tomotake Kanki. Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1. Scientific reports. 2020. 10. 1. 1465-1465
more...
MISC (6):
  • 山下 智大. エコファーマによる新規神経障害性疼痛治療薬の探索. ファルマシア. 2019. 55. 3. 213
  • 津田 誠, 齊藤 秀俊, 山下 智大, 松田 烈士. ミクログリア 脳科学辞典. 2016
  • Tomohiro Yamashita, Makoto Tsuda, Hidetoshi Saitoh, Kazuhide Inoue. Role of P2X7 receptors in regulation of P2X4 receptors expression on the plasma membrane of microglia. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 101P-101P
  • Tomohiro Yamashita, Makoto Tsuda, Hidetoshi Saitoh, Kazuhide Inoue. Assessment of P2X4 receptor function in microglial cells using CTP. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2011. 115. 136P-136P
  • Emika Toyomitsu, Makoto Tsuda, Tomohiro Yamashita, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue. CCL2 increases P2X4 receptor expression on the plasma membrane of microglia. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2010. 112. 91P-91P
more...
Lectures and oral presentations  (5):
  • New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury WCP2018
    (WCP2018 2018)
  • New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury
    (Purines 2018 2018)
  • Microglial ATP receptors in neuropathic pain
    (Purines 2018 2018)
  • グリア細胞およびATP受容体を標的としたアカデミア創薬の実現に向けた「グリーンファルマ研究」の取り組み
    (薬学会137年会 2017)
  • デュロキセチンによるミクログリアに発現するP2X4受容体の阻害作用および末梢神経損傷に伴う神経障害性疼痛に対する改善効果
    (第90回日本薬理学会年会 2017)
Professional career (1):
  • 薬学博士 (九州大学)
Association Membership(s) (3):
THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE JAPANESE PHARMACOLOGICAL SOCIETY
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