Hayashi Yoshihiro

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://lab-cpbt2023.ph.ritsumei.ac.jp/

Research field (3)： Pathobiochemistry , Tumor biology , Hematology and oncology

Research keywords (6)：自然免疫 , 骨髄異形成症候群 , ミトコンドリア , HIF1A , Pseudohypoxia , がん悪液質

Research theme for competitive and other funds (4)：

2023 - 2026 Targeting immune cells derived from tumor clones in the pathogenesis of hematological malignancy-related systemic organ failure
2022 - 2024 ミトコンドリア動態異常を標的とする骨髄異形成症候群の新規治療法開発
2020 - 2022 Dysregulated mitochondrial dynamics as an underlying mechanism of MDS bone marrow failure
2018 - 2020 Targeting inflammatory polarization of macrophages and cell surface calreticulin in hemophagocytic lymphohistiocytosis

Papers (34)：

Yoshihiro Hayashi, Hironori Harada. Mitochondrial dynamics as a pathobiological mediator of clonal myeloid disorders. Cancer science. 2023
Naoki Ikeda, Hiroaki Kubota, Risa Suzuki, Mitsuki Morita, Ayana Yoshimura, Yuya Osada, Keigo Kishida, Daiki Kitamura, Ayaka Iwata, Satoshi Yotsumoto, et al. The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell reports. 2023. 42. 3. 112165-112165
Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, et al. A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nature communications. 2023. 14. 1. 23-23
Yoshihiro Hayashi, Yuka Harada, Hironori Harada. Myeloid neoplasms and clonal hematopoiesis from the RUNX1 perspective. Leukemia. 2022. 36. 5. 1203-1214
林嘉宏, 原田浩徳. ミトコンドリア異常による骨髄異形成症候群の発症機序. 血液内科. 2022. 84. 3. 375-380

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MISC (58)：

HAYASHI Yoshihiro. Role of HIF1A in the development of myelodysplastic syndromes. Rinsho Ketsueki. 2019. 60. 7. 818-823
Yoshihiro Hayashi, Yuka Harada, Yuki Kagiyama, Naoki Shingai, Norio Komatsu, Hirotaka Matsui, Issay Kitabayashi, Atsushi Iwama, Toshio Kitamura, Hironori Harada. Aberrant Histone Acetylation by HBO1-fusion Generates Clinically Relevant CMML Pathogenesis. CANCER SCIENCE. 2018. 109. 743-743
林嘉宏, 原田結花, 鍵山侑希, 丁曄, 今川潤, 新谷直樹, 加藤菜穂子, 北浦次郎, 小松則夫, 松井啓隆, et al. NUP98-HBO1によるヒストンアセチル化制御異常は慢性骨髄単球性白血病を引き起こす(NUP98-HBO1 induces clinically relevant CMML pathogenesis through aberrant histone acetylation). 臨床血液. 2018. 59. 9. 1518-1518
林嘉宏, 原田結花, 鍵山侑希, 新谷直樹, 小松則夫, 松井啓隆, 北林一生, 岩間厚志, 北村俊雄, 原田浩徳. ヒストンアセチル化制御破綻による慢性骨髄単球性白血病の新規発症機序(Aberrant Histone Acetylation by HBO1-fusion Generates Clinically Relevant CMML Pathogenesis). 日本癌学会総会記事. 2018. 77回. 1099-1099
Yokota A, Hirai H, Sato A, Kamio N, Hayashi Y, Miura Y, Kimura S, Maekawa T. IFN-α Upregulates the Expression of C/EBPβ and Induces Myeloid Differentiation and Exhaustion of CD34+ CML Stem Cells. American Society of Hematology, 59th Annual Meeting and Exposition. 2017

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Professional career (1)：

博士(医学) (滋賀医科大学)

Work history (9)：

2023/04 - 現在 Ritsumeikan University Laboratory of Cancer Pathobiology and Therapeutics Professor
2020/04 - 2023/03 Tokyo University of Pharmacy and Life Sciences School of Life Science
2017/04 - 2020/03 Tokyo University of Pharmacy and Life Sciences School of Life Science
2013/09 - 2017/03 Cincinnati Children's Hospital Medical Center
2013/04 - 2013/08 済生会滋賀県病院血液内科医長

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Awards (8)：

2018/10 - Japan Leukaemia Research Fund Research Award
2017/05 - International Symposium on Myelodysplastic Syndromes Tito Bastianello Young Investigator Award
2016/12 - American Society of Hematology Abstract Achievement Award
2015/12 - American Society of Hematology Abstract Achievement Award
2014/12 - American Society of Hematology Abstract Achievement Award

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Association Membership(s) (5)：

The American Society of Hematology , THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE SOCIETY OF HEMATOLOGY , THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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