Rchr
J-GLOBAL ID:201801016325894310   Update date: Apr. 17, 2024

Shichino Shigeyuki

シチノ シゲユキ | Shichino Shigeyuki
Affiliation and department:
Job title: Assistant professor
Research field  (5): Systems genomics ,  Tumor biology ,  Molecular biology ,  Genomics ,  Experimental pathology
Research keywords  (9): fibrosis, murine model, single-cell RNA-seq ,  Transcroptome, single-cell, interactome network ,  fibrosis ,  シングルセルオミクス解析 ,  がん ,  バイオインフォマティクス ,  オミクス解析 ,  呼吸器疾患 ,  免疫・炎症
Research theme for competitive and other funds  (10):
  • 2023 - 2026 Developing a pneumoconiosis atlas at the single-cell resolution
  • 2022 - 2025 Establishment of interstitial literacy based on complex systems crosstalk
  • 2022 - 2025 Investigation of the roles of stromal cell interactions in lung-bone marrow crosstalk
  • 2020 - 2023 増殖の臓器指向性と一細胞遺伝子発現解析に基づく治療最適抗腫瘍T細胞クローンの同定
  • 2020 - 2023 新規シングルセル解析法を用いたじん肺発症-進展における包括的基盤研究
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Papers (68):
  • Hiroyasu Aoki, Masahiro Kitabatake, Haruka Abe, Peng Xu, Mikiya Tsunoda, Shigeyuki Shichino, Atsushi Hara, Noriko Ouji-Sageshima, Chihiro Motozono, Toshihiro Ito, et al. CD8+ T cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominance. Cell reports. 2024. 43. 3. 113887-113887
  • Tanakorn Srirat, Taeko Hayakawa, Setsuko Mise-Omata, Kensuke Nakagawara, Makoto Ando, Shigeyuki Shichino, Minako Ito, Akihiko Yoshimura. NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment. Cell reports. 2024. 43. 3. 113898-113898
  • Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Frank Brombacher, Shigeyuki Shichino, Soichiro Yoshikawa, Sachiko Miyake, Hajime Karasuyama. Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model. Nature communications. 2024. 15. 1. 1666-1666
  • Yoshiya Horimoto, May Thinzar Hlaing, Harumi Saeki, Kaori Denda-Nagai, Katrin Ishii-Schrade, Haruhiko Fujihira, Masaaki Abe, Miki Noji, Shigeyuki Shichino, Mitsue Saito, et al. Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases. Clinical & experimental metastasis. 2024
  • Sadahiro Iwabuchi, Kenta Takahashi, Kazunori Kawaguchi, Akihisa Nagatsu, Tadashi Imafuku, Shigeyuki Shichino, Kouji Matsushima, Akinobu Taketomi, Masao Honda, Shinichi Hashimoto. Phospholipase A2 Group IIA Is Associated with Inflammatory Hepatocellular Adenoma. Cancers. 2023. 16. 1
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MISC (9):
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Patents (6):
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Books (8):
  • 一細胞から観た肺線維症をもたらす炎症細胞社会(Medical Science Digest)
    ニュー・サイエンス社 2022
  • シングルセル・オミックスの解析の発展(炎症と免疫)
    先端医学社 2022
  • 1細胞遺伝子発現解析をはじめとする1細胞オミックス技術の進歩とマクロファージ研究への応用 (シン・マクロファージ あらゆる疾患を制御する機能的多様性)
    羊土社 2022
  • 1細胞遺伝子発現解析をはじめとする1細胞オミックス技術の進歩と現状, The Lipid
    メディカルレビュー社 2021
  • もっとよくわかる!炎症と疾患 : あらゆる疾患の基盤病態から治療薬までを理解する
    羊土社 2019 ISBN:9784758122054
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Lectures and oral presentations  (60):
  • 1細胞からみた肺線維症をもたらす炎症細胞社会
    (第95回日本生化学会大会 2022)
  • 頑健なcDNA増幅法TAS-Seqによる炎症病態シングルセル解析の試み
    (シングルセルゲノミクス研究会2022 2022)
  • Pro-fibrotic properties of C1q producing interstitial macrophages in silica-induced pulmonary fibrosis in mice Presentation Type: On-demand Video Presentation
    (JSICR MMCB 2022 Joint Symposium 2022)
  • 1細胞解析による肺線維症の炎症細胞社会におけるマクロファージの役割の解析
    (第6回トランスレーショナルメディシン研究会 2022)
  • Development of robust scRNA-seq method TAS-Seq amd investigation of the roles of interstitial macrophages in pulmonary fibrosis.
    (第50回日本免疫学会学術集会 2021)
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Education (2):
  • - 2018 The University of Tokyo Graduate School of Medicine, Division of Molecular Preventive Medicine
  • - 2012 The University of Tokyo Faculty of Pharmaceutical Science
Work history (4):
  • 2018 - 現在 Organization for Research Advancement, Tokyo University of Science Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences Assistant professor
  • 2012 - 2018 Graduate School of Medicine, The University of Tokyo Department of Molecular Preventive Medicine Graduate Student
  • 2010 - 2012 The University of Tokyo Faculty of Pharmaceutical Sciences
  • 2008 - 2010 東京大学理科II類
Committee career (1):
  • 2022/04/01 - 2023/03/31 日本免疫学会 免疫若手アカデミー会員
Awards (4):
  • 2017/06 - 若手優秀演題賞
  • 2017/02 - ベストプレゼンテーション賞
  • 2016/01 - 若手優秀発表賞
  • 2014 - The 22nd International Symposium on Molecular Cell Biology of Macrophages Young Investigator Awards Inflammatory monocytes regulate tissue cell turnover and fibrosis diffusion in silica-induced pulmonary fibrosis in mice
Association Membership(s) (2):
Japanese Society of Immunology ,  日本炎症・再生医学会
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