Rchr
J-GLOBAL ID：201801016531217529   Update date: Apr. 02, 2024

Hamada Keisuke

ハマダ ケイスケ | Hamada Keisuke
Affiliation and department：
東京薬科大学 薬学部

About 東京薬科大学 薬学部


Job title： 助教
Research field  (2)： Pharmaceuticals - chemistry and drug development ,  Cell biology
Research keywords  (7)： Lysosome-targeting chimera ,  ペプチド ,  ケミカルバイオロジー ,  DNAアプタマー ,  筋ジストロフィー ,  リードスルー ,  ラミニン
Research theme for competitive and other funds  (3)：
  • 2021 - 2024 インテグリン受容体に結合し細胞接着活性を示すDNAアプタマーの開発
  • 2016 - 2018 リードスルー作用に着目した新規高活性ネガマイシン誘導体の創製とその作用機構の解明
  • 2013 - 2016 Development of anti-cancer agents based on readthrough of nonsense mutation on TP53 gene
Papers (37)：
  • Tingting Yan, Nana Yan, Yangliu Xia, Vorthon Sawaswong, Xinxin Zhu, Henrique Bregolin Dias, Daisuke Aibara, Shogo Takahashi, Keisuke Hamada, Yoshifumi Saito, et al. Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression. The Journal of clinical investigation. 2024. 134. 7
  • Noriko Omura, Akihiro Taguchi, Tomoki Kuwahara, Keisuke Hamada, Mizuki Watanabe, Masanori Nakakuki, Sho Konno, Kentaro Takayama, Atsuhiko Taniguchi, Toshifumi Nomura, et al. Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity. ACS Medicinal Chemistry Letters. 2023
  • Masumi Matsunuma, Ryuji Kan, Yuji Yamada, Keisuke Hamada, Motoi Kanagawa, Motoyoshi Nomizu, Yamato Kikkawa. Chain-specificity of laminin α1-5 LG45 modules in the recognition of carbohydrate-linked receptors and intramolecular binding. Scientific reports. 2023. 13. 1. 10430-10430
  • Keisuke Hamada, Ten Hashimoto, Rinoka Iwashita, Yuji Yamada, Yamato Kikkawa, Motoyoshi Nomizu. Development of a bispecific DNA-aptamer-based lysosome-targeting chimera for HER2 protein degradation. Cell Reports Physical Science. 2023
  • Yuji Yamada, Toru Onda, Yuri Wada, Keisuke Hamada, Yamato Kikkawa, Motoyoshi Nomizu. Structure-Activity Relationships of RGD-Containing Peptides in Integrin αvβ5-Mediated Cell Adhesion. ACS omega. 2023. 8. 5. 4687-4693
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MISC (34)：
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Lectures and oral presentations  (15)：
  • Construction and genetic analysis of the multidrug-sensitive yeast strain for elucidating the mechanism of the readthrough activity of (+)-negamycin
    (2018)
  • Leucyl-3-epi-deoxynegamycinを基盤とした新規リードスルー誘導体の探索
    (日本薬学会第 138 年会 2018)
  • 酵母を用いたnegamycin類縁体によるリードスルー活性の作用機構解析
    (日本農芸化学会関東支部2017年度大会 2017)
  • ネガマイシン天然類縁体の3位アミノ基及びカルボン酸部位に着目した新規高活性リードスルー化合物の創製
    (日本筋学会第3回学術集会 2017)
  • Construction of the multidrug-sensitive yeast strain for elucidating the mechanism of the readthrough activity of (+)-negamycin and its analogues,
    (2016 ASCB Annual Meeting 2016)
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Professional career (1)：
  • 博士 (薬学)
Work history (8)：
  • 2018/07 - 現在 Tokyo University of Pharmacy and Life Sciences Assistant Professor
  • 2021/04 - 2022/03 National Institutes of Health, National Cancer Institute, Laboratory of Metabolism (Frank J. Gonzalez laboratory) Special Volunteer
  • 2018/04 - 2018/06 日本学術振興会特別研究員 (PD)
  • 2018/04 - 2018/06 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
  • 2016/04 - 2018/03 日本学術振興会特別研究員 (DC1)
Show all
Awards (5)：
  • 2019/11 - 日本ペプチド学会 Chemical communication poster award
  • 2016/07 - The 14th Chinese International Peptide Symposium & the 5th Asia-pacific International Peptide Symposium Poster Prize
  • 2015/07 - 日本薬学会 医薬化学部会 創薬懇話会2015 in徳島 最優秀ポスター賞
  • 2015/02 - 平成26年度 東京薬科大学学部学生研究奨励賞
  • 2014/07 - The 18th Korean Peptide Protein Society Symposium 2014 Young Scientist Award
Association Membership(s) (5)：
Japan Muscle Society ,  JAPANESE SOCIETY FOR CHEMICAL BIOLOGY ,  The Japanese Society of Matrix Biology and Medicine ,  The Japanese Peptide Society ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
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