Rchr
J-GLOBAL ID:201801016536366301
Update date: Jun. 20, 2024
Mizuno Seiya
ミズノ セイヤ | Mizuno Seiya
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://www.md.tsukuba.ac.jp/basic-med/lab-animal/
Research field (1):
Laboratory animal science
Research theme for competitive and other funds (20):
- 2022 - 2025 Functional analysis and developing application model of inflammation-genes viewed on lineage-specific differentiation of fibroblasts
- 2022 - 2025 新規direct-cKOシステムでの必須遺伝子探索とその網羅的解析基盤の構築
- 2021 - 2025 Investigation of wound healing in embryo and adult using spatial gene expression analysis
- 2021 - 2024 Developing a versatile technique to create transgenic rodents and medium sized animals
- 2020 - 2024 Biological functions of alternative splicing on mouse gastrulation
- 2021 - 2023 Mutagenesis of non-coding regions via excisional genome editing
- 2021 - 2023 小胞輸送因子が制御する卵母細胞インテグリティ制御機構の解明
- 2019 - 2022 Development of real time in vivo imaging method that can monitor tissue inflammation and fibrosis.
- 2019 - 2022 Establishment of new gene modified moue production system
- 2018 - 2021 Elucidation of the molecular mechanism to maintain hierarchical structure of vascular system and and tumour angiogenesis
- 2017 - 2020 Functional analysis of Exoc1 gene involved in embryonic development and gametogenesis
- 2017 - 2020 Development of mouse-non-human primate chimera analysis innovating evaluation methods of human pluripotent stem cells
- 2017 - 2019 Identification of reproduction isolation gene
- 2014 - 2019 Development of new in vivo imaging technologies by using biological optical window
- 2018 - 2019 無駄のない遺伝子改変動物実験を促進する遺伝型解析技術の開発
- 2015 - 2017 A genetic analysis of REM sleep based on a novel sleep related gene Nalcn
- 2015 - 2017 Development of bicistronic cre driver mice using CRISPR/Cas9
- 2014 - 2017 Functional analysis of Exoc1 gene related to embryo implamtation
- 2014 - 2017 Genetic humanized Mouse production by CRISPITT
- 2014 - 2016 Establishment of XYi-method for generation of multiple genes knock-in mice
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Papers (118):
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Wakasugi, Daiki, Kondo, Shinji, FERDOUSI, Farhana, Mizuno, Seiya, Yada, Akira, Tominaga, Ken-ichi, Takahashi, Satoru, Isoda, Hiroko. A rare olive compound oleacein functions as a TrkB agonist and mitigates neuroinflammation both in vitro and in vivo. CELL COMMUNICATION AND SIGNALING. 2024
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Kimura, Kenichi, Motoyama, Eri, Kanki, Sachiko, Asano, Keiichi, Sheikh, Md Al Amin, Clarin, Maria Thea, Rane, Dela Cruz, Raja, Erna, et al. A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta. Biorxiv. 2024
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Kento Morimoto, Hayate Suzuki, Akihiro Kuno, Yoko Daitoku, Yoko Tanimoto, Kanako Kato, Kazuya Murata, Fumihiro Sugiyama, Seiya Mizuno. Regional random mutagenesis driven by multiple sgRNAs and diverse on-target genome editing events to identify functionally important elements in non-coding regions. Open Biology. 2024. 14. 4
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Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, et al. Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms. Blood Journal. 2024
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Natsuki Mikami, Chi Lieu Kim Nguyen, Yuki Osawa, Kanako Kato, Miyuki Ishida, Yoko Tanimoto, Kento Morimoto, Kazuya Murata, Woojin Kang, Funihiro Sugiyama, et al. Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice. Experimental animals. 2024
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MISC (14):
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藤山知之, 管野里美, 堀田典子, 柿崎美代, 一久綾, 恒岡洋右, 阿部学, 望月綾子, セオーネコラッゾ パトリシア, 宮崎峻弘, et al. 非選択的陽イオンチャネルNalcn遺伝子改変マウスを用いたレム睡眠制御機構の解析. 日本神経化学会大会抄録集(Web). 2022. 65th
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玉里友宏, 池田祥久, 池田祥久, 藤木雄太, 小林慶子, 綾部信哉, 岩間瑞穂, 水野聖哉, 杉山文博, 吉木淳. 電気穿孔法を用いた様々な近交系での遺伝子改変マウス作製. 日本実験動物学会総会講演要旨集(Web). 2021. 68th
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久野朗広, 池田祥久, 綾部信哉, 高橋智, 高橋智, 杉山文博, 水野聖哉. DAJIN:新しいゲノム編集動物の解析技術. 日本生化学会大会(Web). 2021. 94th
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池田祥久, 池田祥久, 久野朗広, 綾部信哉, 坂本航太郎, 鈴木沙耶香, 森本健斗, 脇本新, 三上夏輝, DINH THI Huong Tra, et al. CRISPR-Casベースのゲノム編集結果を検証するためのDAJIN-assisted multiplex genotyping. 日本実験動物学会総会講演要旨集(Web). 2021. 68th
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Cables2 regulates mouse gastrulation by stimulating Wnt/β-catenin signalling pathway. 2019. 66th
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Books (2):
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炎症と免疫
2015
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Clinical Neuroscience.
2015
Lectures and oral presentations (35):
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Hevin/Sparcl1の変異によるASD病態形成への新たな洞察
(第46回日本神経科学大会)
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新規トリプルノックインレポーターシステムを用いたマウス原腸胚における三胚葉形成の評価系の確立
(第63回日本先天異常学会学術集会)
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EFFECTIVENESS OF IMATINIB FOR MCTO NEPHROPATHY
(60th ERA Congress)
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Effectiveness of Imatinib Formcto Nephropathy
(60th ERA Congress)
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ASD-associated SPARCL1 mutant accumulates in the endoplasmic reticulum: implication for a novel mechanism underlying ASD pathogenesis
(36th International mammalian Genome society)
more...
Professional career (2):
- 博士(医学) (筑波大学)
- 博士(医学) (筑波大学)
Work history (3):
- 2023/04 - 現在 University of Tsukuba Faculty of Medicine
- 2019/04 - 2023/03 University of Tsukuba Faculty of Medicine Associate Professor
- 2017/04 - 2019/03 University of Tsukuba Faculty of Medicine
Association Membership(s) (2):
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