Rchr
J-GLOBAL ID：201801016569140678
Update date: Sep. 03, 2024
Kuwata Hiroshi
クワタ ヒロシ | Kuwata Hiroshi
Research field (1)：
Pharmaceuticals - health and biochemistry
Research theme for competitive and other funds (16)：
- 2019 - 2022 The effects of endogenous PUFA restriction on biological functions
- 2016 - 2019 Exploration of novel factors reducing toxicity of environmental chemicals by utilizing toxicolipidomic analyses
- 2013 - 2016 Development of a novel analysis and evaluation system for environmental chemicals-induced toxicity using toxicolipidomics
- 2009 - 2012 Studies on novel mechanisms of environmental chemicals-induced toxicity using arachidonate-metabolizing enzyme genetically modified mice
- 2010 - 2011 Studies on the bioactive phospholipids that regulate various proinflammatory responses
- 2008 - 2009 Studies on a novel bioactive phospholipid (s) that is produced by proinflammatory stimuli.
- 2006 - 2008 Functional analysis of phospholipase A2 by genetically modified mice and its biopharmaceutical application
- 2006 - 2007 炎症性ホスホリパーゼA2発現を調節する新規リン脂質由来生理活性脂質の同定
- 2004 - 2005 ホスホリパーゼA_2経路により産生される新規生理活性脂質の同定とその作用機構の解明
- 2002 - 2005 Analyses of phospholipase A_2 enzymes that are involved in signaling and non-signaling events
- 2002 - 2003 シクロオキシゲナーゼ系、リポキシゲナーゼ系およびリゾリン脂質の機能連関機構の解析
- 2000 - 2001 リポキシゲナーゼ産物により発現調節される遺伝子群の解析
- 2000 - 2001 高等動物ホスホリパーゼA_2の機能、発現、動態の総合評価
- 1998 - 2000 Diversities and functions of phospholipase A_2s in mast cells
- 1998 - 1999 sPLA_2-IIA発現誘導に関与するアラキドン酸代謝酵素群の解析
- 1997 - 1998 Studies on mammalian Ca^<2+>-dependent phospholipase A_2s
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Papers (64)：
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Tsubasa Ochiai, Toshiya Honsawa, Keishi Yamaguchi, Yuka Sasaki, Chieko Yokoyama, Hiroshi Kuwata, Shuntaro Hara. Prostacyclin synthase deficiency exacerbates systemic inflammatory responses in lipopolysaccharide-induced septic shock in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2024
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Hiroshi Kuwata, Eriko Nakatani, Yuki Tomitsuka, Tsubasa Ochiai, Yuka Sasaki, Emiko Yoda, Shuntaro Hara. Deficiency of long-chain acyl-CoA synthetase 4 leads to lipopolysaccharide-induced mortality in a mouse model of septic shock. The FASEB Journal. 2023. 37. 12
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Yuki Tomitsuka, Hiroki Imaeda, Haruka Ito, Isaki Asou, Masayuki Ohbayashi, Fumihiro Ishikawa, Hiroshi Kuwata, Shuntaro Hara. Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation. Redox biology. 2023. 66. 102850-102850
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冨塚 祐希, 桑田 浩, 原 俊太郎. 化学物質曝露に伴う肺傷害における長鎖アシルCoA合成酵素(ACSL)4の機能解析. 脂質生化学研究. 2023. 65. 82-83
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冨塚 祐希, 桑田 浩, 原 俊太郎. パラコートの肺毒性発現における長鎖アシルCoA合成酵素(ACSL)4の役割の解析. The Journal of Toxicological Sciences. 2022. 47. Suppl. S136-S136
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MISC (62)：
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田宮結, 落合翔, 桑田浩, 原俊太郎. Acyl-CoA synthetase long-chain family member 4 (ACSL4) is involved in the pathogenesis of in the colon diseases. 日本薬学会年会要旨集(Web). 2024. 144th
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本沢駿弥, 落合翔, 山口慧士, 桑田浩, 横山知永子, 原俊太郎. Role of Prostacyclin synthase in lipopolysaccharide-induced sepsis in vivo. 日本薬学会年会要旨集(Web). 2024. 144th
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冨塚祐希, 桑田浩, 原俊太郎. ブレオマイシン誘発性肺線維症における長鎖アシルCoA合成酵素(ACSL)4の役割の解析. 脂質生化学研究. 2024. 66
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今枝弘輝, 冨塚祐希, 桑田浩, 原俊太郎. Analysis of the role of long-chain acyl-CoA synthetase (ACSL) 4 in drug-induced lung injury. 日本薬学会年会要旨集(Web). 2024. 144th
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桑田浩, 中谷絵理子, 冨塚祐希, 落合翔, 佐々木由香, 依田恵美子, 原俊太郎. Effects of ACSL4 deficiency on LPS-induced inflammatory responses. 日本薬学会年会要旨集(Web). 2024. 144th
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Committee career (2)：
- 2013/04 - 2015/03 日本薬学会 環境・衛生部会 若手研究者活性化小委員
- 2013/04 - 2015/03 日本薬学会 トピックス小委員会
Awards (1)：
- 2011/10 - 日本薬学会 環境・衛生部会 フォーラム2011:衛生薬学環境トキシコロジー 部会賞・金原賞 炎症反応を司る新奇生理活性脂質に関する研究
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