Kasahara Tomoko

Research field (2)： Genomics , Developmental biology

Research theme for competitive and other funds (14)：

2024 - 2028 Elucidation of the mechanistical principle of collective cell migration in individuals
2024 - 2027 生命と情報
2024 - 2026 加齢時計によるヒトの老化機序解明
2022 - 2024 発生エンハンサーによるヒト腎発生の機序解明
2019 - 2022 心疾患治療に適したヒト心筋細胞の生理作用と分子機構の解明

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Papers (9)：

Alexander Tyshkovskiy, Daria Kholdina, Kejun Ying, Maria Davitadze, Adrian Molière, Yoshiyasu Tongu, Tomoko Kasahara, Leonid M Kats, Anastasiya Vladimirova, Alibek Moldakozhayev, et al. Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation. 2024
Yasutoshi Akiyama, Yoshika Takenaka, Tomoko Kasahara, Takaaki Abe, Yoshihisa Tomioka, Pavel Ivanov. RTCB Complex Regulates Stress-Induced tRNA Cleavage. International Journal of Molecular Sciences. 2022
Masahiro Nagano, Bo Hu, Shihori Yokobayashi, Akitoshi Yamamura, Fumiya Umemura, Mariel Coradin, Hiroshi Ohta, Yukihiro Yabuta, Yukiko Ishikura, Ikuhiro Okamoto, et al. Nucleome programming is required for the foundation of totipotency in mammalian germline development. The EMBO journal. 2022. 41. 13. e110600
Hiraku Tsujimoto, Tomoko Kasahara, Shin-Ichi Sueta, Toshikazu Araoka, Satoko Sakamoto, Chihiro Okada, Shin-Ichi Mae, Taiki Nakajima, Natsumi Okamoto, Daisuke Taura, et al. A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells. Cell reports. 2020. 31. 1. 107476-107476
Hirofumi Hitomi, Tomoko Kasahara, Naoko Katagiri, Azusa Hoshina, Shin-Ichi Mae, Maki Kotaka, Takafumi Toyohara, Asadur Rahman, Daisuke Nakano, Akira Niwa, et al. Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice. Science translational medicine. 2017. 9. 409

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MISC (18)：

笠原朋子. 腎特異的エンハンサーアトラスに基づく発生機序解明. 上原記念生命科学財団研究報告集. 2023. 37. 1-5
蓑輪圭太, 秋山由雅子, 笠原朋子, 何欣蓉, 前川正充, 菊池晃一, 豊原敬文, 鈴木健弘, 鈴木千登世, 鯨井涼太, et al. Elobixibat投与マウスにおける胆汁酸および腸内細菌叢の検討. 日本腎臓学会誌. 2023. 65. 3. 294-294
頓宮慶泰, 笠原朋子, 川邊千陽, 鈴木健新, 菊地晃一, 三瀬広記, 鯨井涼太, 松本洋太郎, 秋山泰利, 渡邉駿, et al. 尿毒素フェニル硫酸はインスリン分泌を刺激し糖尿病性腎症におけるインスリン抵抗性を惹起する. 日本腎臓学会誌. 2023. 65. 3. 336-336
頓宮慶泰, 笠原朋子, 川邊千陽, 鈴木健新, 菊地晃一, 三瀬広記, 鯨井涼太, 松本洋太郎, 秋山泰利, 鈴木千登世, et al. 糖尿病性腎症におけるインスリン分泌促進とインスリン抵抗性亢進の原因に尿毒素フェニル硫酸が存在する. 糖尿病. 2023. 66. Suppl.1. S-209
人見浩史, 笠原朋子, 片桐直子, 保科あずさ, 前伸一, 小高真希, 豊原敬文, Rahman Asadur, 中野大介, 丹羽明, et al. iPS細胞由来エリスロポエチン産生細胞を用いた腎性貧血に対する細胞療法開発. 日本腎臓学会誌. 2018. 60. 3. 359-359

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Patents (3)：

Agent for anti-aging of for cellular rejuvenation
Method for testing drug responsiveness of cardiomyocytes.
Method for inducing differentiation of intermediate mesodermal cell to renal progenitor cell, and method for inducing differentiation of pluripotent stem cell to renal progenitor cell.

Books (2)：

Lectures and oral presentations (1)：

Exploring the biological aging dynamics in a renal development organoid model
(Symposium in MBSJ 2024, Understanding the regeneration, immunology, and disorders of the complex organ kidney from a molecular biological perspective)

Education (2)：

2014 - 2017 Kyoto University Graduate School of Medicine Master Course of Medicine
2011 - 2014 Kyoto University Graduate School of Medicine Master Course of Medicine

Awards (5)：

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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