Research theme for competitive and other funds (2)：
2008 - 2010 リソゾーム病の神経病変を標的とした新規骨髄移植法の開発
2006 - 2008 リソゾーム病の神経病変を標的とした新規遺伝子治療の開発
Papers (25)：
Miyake K, Miyake N, Shimada T. "A New Method for In Vivo Targeted Gene Transfer into Oligodendrocytes using Adenoviral and HIV Vectors". Biomedical Journal of Scientific & Technical Research. 2021. 39. 3
Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Hidenori Suzuki, Takashi Shimada. Treatment of adult metachromatic leukodystrophy model mice using intrathecal administration of type 9 AAV vector encoding arylsulfatase A. Scientific reports. 2021. 11. 1. 20513-20513
Tae Matsumoto, Koichi Miyake, Noriko Miyake, Osamu Iijima, Kumi Adachi, Sonoko Narisawa, José Luis Millán, Hideo Orimo, Takashi Shimada. Treatment with bone maturation and average lifespan of HPP model mice by AAV8-mediated neonatal gene therapy via single muscle injection. Molecular therapy. Methods & clinical development. 2021. 22. 330-337
Hirofumi Yamaguchi, Shinya Honda, Satoru Torii, Kimiko Shimizu, Kaoru Katoh, Koichi Miyake, Noriko Miyake, Nobuhiro Fujikake, Hajime Tajima Sakurai, Satoko Arakawa, et al. Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. Nature communications. 2020. 11. 1. 5311-5311
Kazuhisa Takahashi, Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Chiemi Yaguchi, Osamu Iijima, Yoshiyuki Yamazaki, Noriko Miyake, Shuhei Kameya, Takashi Shimada, et al. Efficient Transduction of Inner Retina by Surgical Internal Limiting Membrane (ILM) Peeling Before Intravitreal AAV Vector Injection in Cynomolgus Monkeys. MOLECULAR THERAPY. 2017. 25. 5. 111-111
Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada. Why Are scAAV9 Vectors Able to Pass Through the BBB but Not ssAAV9?; The Difference Between the ssAAV9 and scAAV9 Vector in Transduction of CNS by Intravenous Injection. MOLECULAR THERAPY. 2017. 25. 5. 320-321
Gene Delivery into the Central Nervous System (CNS) Using AAV Vectors
Intech 2015
Professional career (1)：
医学博士
Committee career (1)：
2022 - 現在 日本遺伝子細胞治療学会評議員
Awards (2)：
2015/07 - Japan Society of Gene and Cell Therapy Award for the Annual Meeting of JSGT Trans-BBB gene therapy for metachromatic leukodystrophy using self-complementary type 9
