Miyamoto Yoichi

ミヤモトヨウイチ | Miyamoto Yoichi

Affiliation and department：

Research field (2)： Oral medicine , Medical biochemistry

Research theme for competitive and other funds (32)：

2022 - 2025 Study on the role of sulfur respiration in homeostasis and disruption of the skeletal system under hypoxic conditions
2021 - 2024 Elucidation of bone formation promoting function by BMP agonist KCP, and application to hard tissue reconstruction
2021 - 2024 The study on the role of reactive sulfur species in the pathogenesis of periodontitis
2019 - 2022 Regulation of bone remodeling by reactive sulfur species, the novel signal molecules
2018 - 2021 Study on the physiological and pathological function of 8-nitro-cGMP in bone remodeling.

2016 - 2020 Development of the periodontal therapy by the stromal cell derived factor -Analysis of periodontal ligament cells derived from Down's syndrome -

2017 - 2019 An in vitro study of reactive sulfur species for treatment of cartilage diseases

2015 - 2019 Understanding of periodontal bone loss based on the interaction of bacterial protease toxins and host factors

2015 - 2018 On the regulatory mechanism of hard tissue metabolism by 8-nitro-cGMP

2012 - 2015 The role of lysine-specific gingipain in inflammatory bone loss in periodontitis.

2011 - 2013 Regulation of differentiation of hard-tissue-constituting cells by pH regulating proteins. Clarification of the mechanism and its application for regenerative medicine.

2009 - 2011 A study on the mechanism of bone resorption by gingipains, the major proteases produced by Porphyromonas gingivalis

2009 - 2011 Establishment of tooth regeneration using spheroid culture of neural crest-derived cells in bone marrow

2008 - 2010 Identification of regulatory molecules for osteogenic activity of BMP.

2006 - 2007 Study on the roles of dendritic cells in inflammatory bone destruction

2006 - 2007 The analysis of epigenetic regulation of osteoblastogenesis induced by BMP-2

2006 - 2007 Functional analysis of nitric oxide metabolites in hard tissues

2004 - 2005 On the regulation of survival and death of synoviocytes and chondrocytes by nitric oxide

2004 - 2005 Enhancement of BMP activity in vivo by heparin and analysis of its molecular mechanisms.

2003 - 2004 Mechanisms of bone resorption in alveolar bone of IL-1 transgenic mice

2001 - 2002 フリーラジカルによるヘリコバクターピロリ遺伝子の変異促進作用に関する研究

2000 - 2002 Research on microbial mutation and evolution involving oxidative stress

2000 - 2002 Research on the role of NO in microbial pathogenesis

2000 - 2002 Development of analysis for all biologically relevant derivatives of NO

2000 - 2002 Study on the mechanism of nitrosothiol formation in biological systems

2001 - 2001 新規水溶性ヘムオキシゲナーゼ阻害剤の合成とその抗腫瘍活性

2000 - 2000 慢性感染に伴うフリーラジカル産生と発がん

2000 - 2000 固型腫瘍の発育・進展における一酸化窒素・酸素ラジカルの役割についての研究

1999 - 1999 Free radical generation in chronic infection and its implication in carcinogenesis

1998 - 1999 生体内ニトロソチオールの生成と生物活性の解析

1998 - 1999 フリーラジカルによるウイルス遺伝子変異メカニズムの解明

1997 - 1999 Matrix metalloproteinase activation in bacterial pathogenesis

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Papers (93)：

Yuji Sasama, Kentaro Yoshimura, Marie Hoshino, Kiyohito Sasa, Takaaki Akaike, Masanobu Morita, Kazuyoshi Baba, Tatsuo Shirota, Yoichi Miyamoto. Supersulfides support bone growth by promoting chondrocyte proliferation in the growth plates. Journal of Oral Biosciences. 2024. 66. 1. 76-81
Ryota Kawai, Risa Sugisaki, Yoichi Miyamoto, Fumiko Yano, Kiyohito Sasa, Erika Minami, Koutaro Maki, Ryutaro Kamijo. Cathepsin K degrades osteoprotegerin to promote osteoclastogenesis in vitro. In vitro cellular & developmental biology. Animal. 2023. 59. 1. 10-18
Rie Nishida, Dai Suzuki, Yoshihiro Akimoto, Sachie Matsubara, Junri Hayakawa, Akira Ushiyama, Kiyohito Sasa, Yoichi Miyamoto, Takehiko Iijima, Ryutaro Kamijo. Exploring the pathophysiological mechanism of interstitial edema focusing on the role of macrophages and their interaction with the glycocalyx. Journal of oral biosciences. 2023. 65. 1. 111-118
Tetsutaro Yamaguchi, Kazuyoshi Hosomichi, Tatsuo Shirota, Yoichi Miyamoto, Wanida Ono, Noriaki Ono. Primary failure of tooth eruption: Etiology and management. Japanese Dental Science Review. 2022. 58. 258-267
Kotaro Kaneko, Yoichi Miyamoto, Tomoaki Ida, Masanobu Morita, Kentaro Yoshimura, Kei Nagasaki, Kazuki Toba, Risa Sugisaki, Hozumi Motohashi, Takaaki Akaike, et al. 8-Nitro-cGMP suppresses mineralization by mouse osteoblasts. Journal of Clinical Biochemistry and Nutrition. 2022. 71. 3. 191-197

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MISC (162)：

河合良太, 宮本洋一, 矢野文子, 長濱諒, 槇宏太郎, 上條竜太郎. 生体内プロテアーゼによる骨代謝調節カテプシンKによるオステオプロテゲリンの分解. 口腔組織培養学会誌. 2023. 32. 1. 15-16
河合良太, 宮本洋一, 矢野文子, 長濱諒, 上條竜太郎, 槇宏太郎. 破骨細胞由来プロテアーゼによる破骨細胞分化の調節. 日本矯正歯科学会大会プログラム・抄録集. 2022. 81回. 172-172
金子児太郎, 宮本洋一, 杉崎リサ, 上條竜太郎, 近津大地. 酸化ストレスのシグナル分子8-ニトロ-cGMPによる骨代謝調節. 日本口腔科学会雑誌. 2021. 70. 2. 135-135
笹清人, 吉村健太郎, 宮本洋一, 上條竜太郎. モノカルボン酸トランスポーター1は骨芽細胞分化の負の調節因子p53の抑制を介して骨芽細胞分化を促進する. Journal of Oral Biosciences Supplement. 2020. 2020. 56-56
瀧本玲子, 田中元博, 笹清人, 山田篤, 宮本洋一, 須澤徹夫, 吉村健太郎, 上條竜太郎. ゾレドロン酸はIRF8の発現誘導を介して末梢血単球の破骨細胞分化を抑制する. Journal of Oral Biosciences Supplement. 2019. 2019. 200-200

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Books (15)：

レドックスと疾患
実験医学 (羊土社) 2018
活性イオウ分子種の生理機能に迫るチオールバイオロジーの新たなステージ
細胞工学(株)学研メディカル秀潤社 2015
アンチエイジングシリーズ3 骨研究最前線~代謝・疾病のメカニズムから再生医療・創薬・リハビリ機器・機能性食品開発まで~
(株)エヌ.ティー.エス出版 2013
The New Frontiers in Research for Oral Cancer
MARUZEN. CO. LTD, Tokyo 2012
生体内一酸化窒素(NO)実験プロトコール
2000

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Lectures and oral presentations (155)：

生体内プロテアーゼによる骨代謝調節カテプシンKによるオステオプロテゲリンの分解
(口腔組織培養学会誌 2023)
Memories of Kumamoto
(4th International Conference on Persulfide and Sulfur Metabolism inBiology and Medicine 2022)
The roles of sulfides in bone resorption.
(4th International Conference on Persulfide and Sulfur metabolism in Biology and Medicine 2022)
破骨細胞由来プロテアーゼによる破骨細胞分化の調節
(日本矯正歯科学会大会プログラム・抄録集 2022)
酸化ストレスのシグナル分子8-ニトロ-cGMPによる骨代謝調節
(日本口腔科学会雑誌 2021)

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Education (2)：

1984 - 1986 University of Tsukuba Master's Course for Medical Sciences
1980 - 1984 University of Tsukuba College of Agriculture, Second Cluster of Colleges

Professional career (1)：

博士(医学) (熊本大学)

Work history (9)：

2022/04 - 現在 Showa University Faculty of Arts and Sciences at Fujiyoshida Professor
2021/09 - 2022/03 Showa University School of Dentistry Department of Biochemistry Professor
2010/07 - 2021/09 Showa University School of Dentistry Department of Biochemistry Associate Professor
2004/06 - 2010/06 Showa University School of Dentistry Department of Biochemistry Associate Professor
2002/03 - 2004/05 Showa University School of Dentistry Department of Biochemistry Associate Professor

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Awards (2)：

2017 - 歯科基礎医学会平成29年度歯科基礎医学会ベストペーパー賞 Degradation of bradykinin by a metallopeptidase from Streptococcus pyogenes.
2012 - 昭和大学平成24年度上條奨学賞(研究業績) 硬組織構成細胞の分化・機能調節

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