Naoto Kubota

クボタナオト | Naoto Kubota

Affiliation and department：
Job title： Instructor

Research field (3)： Genomics , Experimental pathology , Human pathology

Research keywords (5)： Oncology , Biliary Disease , Pancreatic Disease , Hepatology , Pathology

Research theme for competitive and other funds (1)：

2024 - 2027 胆管癌のシングルセル遺伝子発現解析と形態解析に基づく腫瘍層別化と治療への応用

Papers (28)：

Mender I., Siteni S., Barron S., Flusche A.M., Kubota N., Yu C., Cornelius C., Tedone E., Maziveyi M., Grichuk A., et al. Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma. Molecular cancer therapeutics. 2023. 22. 6. 737-750
Saito Y, Yin D, Kubota N, Wang X, Filliol A, Remotti H, Nair A, Fazlollahi L, Hoshida Y, Tabas I, et al. A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23. Gastroenterology. 2023. 164. 7. 1279-1292
Wang Z, Zhu S, Jia Y, Wang Y, Kubota N, Fujiwara N, Gordillo R, Lewis C, Zhu M, Sharma T, et al. Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease. Cell. 2023. 186. 9. 1968-1984.e20
Wang X., He Q., Zhou C., Xu Y., Liu D., Fujiwara N., Kubota N., Click A., Henderson P., Vancil J., et al. Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development. Immunity. 2023. 56. 1. 58-77.e11
Fujiwara N., Kubota N., Zhu S., Nakagawa S., Baba H., Hoshida Y. Disseminative Recurrence Signature for Hepatocellular Carcinoma From Nonalcoholic Fatty Liver Disease. Gastro hep advances. 2023. 2. 5. 681-683

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MISC (22)：

Dhanasekaran R., Suzuki H., Lemaitre L., Kubota N., Hoshida Y. Molecular and immune landscape of hepatocellular carcinoma to guide therapeutic decision making. Hepatology (Baltimore, Md.). 2023
Zhu S., Kubota N., Hoshida Y. Transcriptome-Guided Design of Physiological Multilineage Liver Organoids. Trends in Genetics. 2021. 37. 5. 403-404
圓谷泰章, 隅山昌洋, 浅利佳奈, 宇田川崇, 入江理恵, 久保田直人, 長村義之. 難治性胸水を発症し、剖検でEBウイルス関連血球貪食性リンパ組織球症(EBV-HLH)が疑われた透析患者の1例. 日本内科学会関東地方会. 2021. 666回. 52-52
久保田直人, 尾島英知, 坂元亨宇. 【肝・胆道系症候群(第3版)-その他の肝・胆道系疾患を含めて-肝臓編(下)】肝腫瘍肝細胞腺腫. 日本臨床. 2021. 別冊. 肝・胆道系症候群II. 136-141
Effendi Kathryn, Kwa Wit Thun, 山崎剣, Kubota Naoto, Ueno Akihisa, 眞杉洋平, 坂元亨宇. 肝細胞癌におけるテロメラーゼ逆転写酵素プロモーター変異と腫瘍内不均一性との関連性(Telomerase Reverse Transcriptase Promoter Mutation Correlated with Intratumor Heterogeneity in Hepatocellular Carcinoma). 日本癌学会総会記事. 2020. 79回. OE14-5

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Books (1)：

Liver cancer risk-predictive molecular biomarkers specific to clinico-epidemiological contexts
Advances in Cancer Research 2022 ISBN:9780323983921

Lectures and oral presentations (8)：

肝細胞癌において、組織学的・分子生物学的分類に加えて免疫微小環境を評価する意義について(会議録)
(日本病理学会 2018)
胆嚢原発の脱分化型脂肪肉腫の一例(会議録)
(日本病理学会 2018)
肝細胞癌胆管内腫瘍進展を病理学的に考察する上で参考となる特殊な混合型肝癌の一例(会議録/症例報告)
(日本肝臓学会西部会 2017)
切除不能肝内胆管癌に対するConversion surgeryを施行した2症例の画像所見と病理組織の検討(会議録/症例報告)
(日本肝胆膵外科学会 2016)
肝転移を伴う進行胃癌に対してSOX(S-1/Oxaliplatin)療法が奏効し、根治手術をし得た1例(会議録/症例報告)
(日本胃癌学会 2016)

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Education (2)：

2014 - 2018 Keio University the medical department
2006 - 2012 Keio University Medical faculty

Professional career (1)：

PhD (Medical science) (Keio University)

Work history (8)：

2023/04 - 現在 Keio University Hospital 病理診断科
2021/11 - 2023/03 University of Texas Southwestern Medical Center
2020/04 - 2020/10 Keio University 医学部病理学教室
2019/04 - 2020/03 NIPPON KOUKAN HOSPITAL
2018/04 - 2019/03 Keio University 医学部病理学教室助教

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Awards (2)：

2017/12/01 - The Japan Society of Hepatology 若手医師症例報告奨励賞 Japan
2017/12 - The Japan Society of Hepatology 若手医師症例報告奨励賞肝細胞癌胆管内腫瘍進展を病理学的に考察する上で参考となる特殊な混合型肝癌の一例

Association Membership(s) (4)：

The Japanese Society of Pathology , The Japanese society of clinical cytology , The Japanese Society of Hepatology , Liver Cancer Study Group of Japan

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