Rchr
J-GLOBAL ID：201801016963198134
Update date: Feb. 06, 2024
Araki Yoshihiko
アラキヨシヒコ | Araki Yoshihiko
Affiliation and department：
Other affiliations (1)：
Homepage URL (1)：
http://www.nihon-u.med-microbe.jp/staff.html
Research field (7)：
Sociology/history of science and technology
, Laboratory animal science
, Animals: biochemistry, physiology, behavioral science
, Immunology
, Clinical pharmacy
, Physiology
, Obstetrics and gynecology
Research keywords (7)：
hypertensive disorders of pregnancy
, oviduct
, gametogenesis
, cell to cell interaction
, oligosaccharide
, implantation
, fertilization
Research theme for competitive and other funds (62)：
- 2022 - 2026 脈管内がん幹細胞の胚シグナル分子による微小環境形成機構とそれを標的にした治療戦略
- 2022 - 2025 Ontogeny of the mammalian oviduct: a metabolomic analysis of the effects of its microenvironment on the fertilized egg
- 2021 - 2025 新規胚シグナルlaeverinの幹細胞と免疫システムに対する作用の解明と臨床応用
- 2021 - 2024 糖鎖伸長抑制因子「バイセクト型糖鎖」の雄性生殖細胞分化制御能の解析
- 2021 - 2024 New peptide biomarkers for prevention and mechanistic investigation of alcohol-induced hypertension
- 2020 - 2023 可溶型CD163分子による遊離ヘモグロビン細胞毒性回避機構解明と分子創薬への応用
- 2020 - 2023 卵管分泌因子機能不全による新規不育症モデル動物の胚・雌性生殖管超微細構造の分析
- 2019 - 2021 Identification and analysis of a new group of diseases with a common etiology of abnormal immune response to embryonic signals
- 2018 - 2021 Oviduct as the site of fertilization and early embryonic development: Verification of its physiological functions using genetically engineering hamster model for clinical application
- 2018 - 2021 受精/初期発生の場としての卵管:その生理機能の分子論的検証と臨床応用への基盤構築
- 2017 - 2020 Promoting mechnisms of embryonic signals in embryo implantation induced by the immune system
- 2016 - 2020 Study of reproductive biological functions of bisecting GlcNAc using glycotechnology and immunological methods
- 2017 - 2020 多形核白血球の挙動から見る女性の生理学的特性:細胞レベルに性差はあるか?
- 2017 - 2019 Identification and analysis of circulating embryonic stem cells derived from human chorionic stroma at early stage
- 2017 - 2019 Physiological characteristics of female in terms of polymorphonuclear leukocyte behavior: Are there sex-differences at the cellular level?
- 2016 - 2019 Analysis of soluble factor in menstrual blood or follicular fluid associated with fallopian tubal carcinogenesis
- 2015 - 2018 Development of a pathophysiological evaluation method for hypertensive disorders of pregnancy by simultaneous quantitation analysis of multiple disease biomarkers.
- 2016 - 2017 Analysis of chorionic villi-derived embryo stem cells by novel sten cell markers, laeberin and hTERT
- 2014 - 2017 Identification of embryo-derived implantation-inducing factors (embryonic signals) and their clinical application
- 2013 - 2016 Structural and functional analyses of reproduction-specific carbohydrate antigen recognized by an auto-antibody, Ts4
- 2012 - 2016 Developent of new drug delivery system using targeted liposomes for age-related macular degeneration
- 2013 - 2016 自然抗体により認識される生殖過程特異糖鎖抗原の構造及び生理機能の解明
- 2013 - 2015 Platelet-induced re-epithelialization and its failure
- 2012 - 2015 Development of cancer/testis antigen, TEX101-targeted therapy in head and neck squamous cell carcinoma
- 2012 - 2014 Challenging study to clarify mechanisms of multiple organ failure
- 2011 - 2014 Analysis of maternal recognition through embryo-specific sugar antigen and its inducing mechanisms for embryo implantation and placentation
- 2011 - 2013 妊娠高血圧症候群予知診断法の開発
- 2009 - 2012 遺伝子工学・細胞生物学的アプローチによる配偶子形成過程における分子基盤の解明
- 2012 - 2012 Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin
- 2011 - 2011 Induction of tissue remodeling of reproductive organs using gligl stem cell-derived factors
- 2009 - 2011 Epigenetic control of gene expression associated with adult diseases due to fetal nutritional factors
- 2009 - 2011 Elucidation of the molecular basis on mammalian gametogenesis by genetic engineering and cell biological techniques
- 2009 - 2011 Expression and clinical analysis of a novel cancer/testis antigen, TEX101 in head and neck squamous cell carcinoma
- 2006 - 2008 プロテオミクスを用いた配偶子形成過程における分子基盤の解析
- 2007 - 2008 Analysis of gonad developmental mechanisms concerning of a germ cell-specific antigen, TEX101 through gene transfer
- 2005 - 2007 女性生殖器腫瘍の分子標的抗体
- 2006 - 2007 Structural and Functional Analysis of glycoproteins participating in the mammalian fertilization and development
- 2006 - 2007 Mechanisms underlying the role of DNA methylation in fetal programming of adult disease in the neonatal mouse
- 2006 - 2007 IDENTIFICATION OF TESTICULAR PROTEINS ASSOCIATED WITH THE GERM CELL-SPECIMC PROTEIN, TEX101 : CELLUBREVIN IS INVOLVED IN TEX101-TRAFFICKING TO THE GERM CELL SURFACE DURING SPERMATOGENESIS IN MICE
- 2004 - 2006 エピジェネティクスからみた生殖補助技術の配偶子・受精卵ゲノムへ の影響解析
- 2005 - 2006 Prevention for dyslipidemia and obesity based on gender-specific difference in middle-aged women
- 2004 - 2005 BASIC STUDY FOR EPIGENETIC EFFECT(S) CAUSED BY ASSISTED REPRODUCTIVE TREATMENT ON THE GERM-CELL/ZYGOTE
- 2002 - 2004 遺伝子改変モデル動物を用いた雌性生殖管の受精時における分子制御機構の解析
- 2002 - 2003 Functional analysis of neutrophils that infiltrated in the S.mansoni-induced hepatic granuloma
- 2002 - 2003 Analysis of molecular regulation on female reproductive tract during fertilization using genetic model mice
- 1999 - 2001 遺伝子改変マウスを用いた卵管特異糖蛋白質生殖生物学的生理活性の解明
- 1997 - 1999 Inverse PCR法を用いた卵管特異糖蛋白質遺伝子プロモーター領域の解析
- 1997 - 1998 マストミス体外受精・凍結保存の開発
- 1997 - 1998 The mouse oviduct-specific glycoprotein gene : Genomic organization and structure of the 5'-flanking regulatory region
- 1997 - 1997 Invitation Fellowship for Research in Japan
- 1996 - 1997 PCR法を用いた卵管特異糖蛋白質のゲノムクローニングとその発現機構の解明
- 1996 - 1997 卵管特異糖タンパク質の生理機能解明(2)
- 1995 - 1996 In situ ハイブリダイゼーション 法を用いた卵管特異糖蛋白質の発現機構の解明
- 1995 - 1996 遺伝子相同組み換えを用いた卵管特異糖蛋白質の生殖生理学的活性の解明
- 1996 - 1996 PCR法を用いた卵管特異糖蛋白質のゲノムクローニングとその発現機構の解明
- 1995 - 1996 Development of an easy and quick serodiagnostic method for important parasitosis using geratine particles coated with recombinant parasite antigens
- 1993 - 1996 Mechanism of fertilization and embryo development
- 1994 - 1995 卵管特異糖タンパク質の生理機能解明
- 1993 - 1995 分子生物学的アプローチによる哺乳類卵透明帯の構造解析
- 1995 - 1995 Functional analysis of oviduct-specific glycoproteins in the reproductive system using homologous recombination
- 1995 - 1995 In situハイブリダイゼーション法を用いた卵管特異糖蛋白質の発現機構の解明
- 1993 - 1994 分子生物学的アプローチによる哺乳類卵透明帯の構造解析
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Papers (112)：
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Kenji Yamatoya, Masaru Kurosawa, Michiko Hirose, Yoshiki Miura, Hikari Taka, Tomoyuki Nakano, Akiko Hasegawa, Kyosuke Kagami, Hiroshi Yoshitake, Kaoru Goto, et al. The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster. Biology of Reproduction. 2023
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Hideaki Nitta, Haruko Takizawa, Toru Mitsumori, Hiroko Iizuka-Honma, Yoshihiko Araki, Maki Fujishiro, Shigeki Tomita, Satsuki Kishikawa, Akane Hashizume, Tomohiro Sawada, et al. Possible New Histological Prognostic Index for Large B-Cell Lymphoma. Journal of Clinical Medicine. 2023. 12. 19. 6324-6324
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Ichiro Wakabayashi, Yoko Sotoda, Shigeki Hirooka, Hiroyuki Orita, Mitsuaki Yanagida, Yoshihiko Araki. Peptides associated with hypertensive disorders of pregnancy as possible biomarkers for severity of lower extremity arterial disease. Atherosclerosis. 2023. 376. 63-70
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Haruko Takizawa, Yoshihiko Araki, Maki Fujishiro, Shigeki Tomita, Satsuki Kishikawa, Akane Hashizume, Toru Mitsumori, Hideaki Nitta, Hiroko Iizuka-Honma, Tomohiro Sawada, et al. Role of TGF-beta1 and TNF-alpha1 produced by neoplastic cells in the pathogenesis of fibrosis in patients with hematologic neoplasms. Journal of Clinical and Experimental Hematopathology. 2023. 63. 2. 83-89
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Ishin Ninomiya, Kenji Yamatoya, Keitaro Mashimo, Akira Matsuda, Ayumi Usui-Ouchi, Yoshihiko Araki, Nobuyuki Ebihara. Role of Oncostatin M in the Pathogenesis of Vernal Keratoconjunctivitis: Focus on the Barrier Function of the Epithelium and Interleukin-33 Production by Fibroblasts. Investigative ophthalmology & visual science. 2022. 63. 13. 26-26
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MISC (142)：
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荒木慶彦. 感染症パンデミックの実体験から見たウイルスと人間の共生 - 医学教育における本質論を意識した雑学の勧め -. 日本臨床検査医学会雑誌. 2022. 70. 169-174
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荒木慶彦. 原始哺乳類からヒト・人間への進化と性 -性別という世の煩悩の起源について-. 性の健康. 2019. 18. 18-21
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小田理沙子, 小田理沙子, 吉武洋, 數野彩子, 三浦芳樹, 上野隆, 櫻庭真弓, 高森建二, 長谷川昭子, 藤原浩, et al. CD73:バイセクト型N-アセチルグルコサミン糖鎖構造を認識する抗精子自己抗体Ts4の精巣内生殖細胞における標的候補分子. Reproductive Immunology and Biology. 2018. 33. 1-2. 102-102
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荒木慶彦, 柳田光昭. ポストゲノムダイナミクスと検査医学への展望 ペプチドームを基盤とする疾患診断法-現状・展望およびその検査医学的技術限界-. 臨床化学. 2018. 47. 3. 243-249
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荒木慶彦. 生命現象の本質としての生殖-生命の維持における時間軸と技術の進歩について-. 日本生殖医学会雑誌. 2018. 63. 1/2. 111-111
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Patents (2)：
Books (9)：
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Uterine Endometrial Function (Kanzaki H. ed.)
Springer Japan 2016
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最先端バイオマーカーを用いた診断薬/診断装置開発と薬事対応
技術情報協会 2015
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New Discoveries of Embryology (Wu B. ed.)
InTech Open Access Publisher 2015
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The Human Embryo (Yamada S., Takakuwa T. eds)
InTech Open Access Publisher 2012
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生命科学研究の原点 : 「プロ」をめざす君たちへ
青山社 2003 ISBN:4883591034
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Education (2)：
- 1983 - 1987 Yamagata University
- 1977 - 1983 Yamagata University School of Medicine
Professional career (1)：
Work history (24)：
- 2023/04 - 現在 山形大学医学部解剖学第2 非常勤講師
- 2022/04 - 現在 Juntendo University Graduate School of Medicine Department of OB/GYN
- 2019/04 - 現在 Nihon University School of Medicine Microbiology & Immunology Visiting Professor
- 2015/04 - 現在 Kanazawa University
- 2013/04 - 現在 Kagoshima University Graduate School of Medical and Dental Sciences
- 2007/04 - 2023/03 Hyogo College of Medicine
- 2018/04 - 2022/03 Juntendo University Graduate School of Medicine Institute of Environmental and Gender-specific Medicine Deputy director
- 2013/04 - 2022/03 Akita University School of Medicine
- 2009/04 - 2022/03 Juntendo University Graduate School of Medicine Obstetrics & Gynecology Associate Professor
- 2004/05 - 2022/03 Juntendo University Graduate School of Medicine Institute for Environmental & Gender-specific Medicine Associate Professor (Group reader)
- 2004/05 - 2020/03 Yamagata University Faculty of Medicine
- 2005/04 - 2008/03 Waseda University School of Human Sciences
- 2004/04 - 2005/03 Yamagata University
- 2001/07 - 2004/04 Yamagata University School of Medicine Department of Immunology Associate Professor
- 1999/04 - 2001/06 Vanderbilt University School go Medicine Department of OB/GYN Research Associate Professor
- 1997/04 - 1999/03 Yamagata University Faculty of Medicine
- 1997/04 - 1999/03 Yamagata University School of Medicine Department of Immunology & Parasitology Associate Professor
- 1995/04 - 1997/03 Yamagata University Hospital Dept. of OB/GYN Director, Assistant Professor
- 1992/10 - 1995/03 Yamagata University School of Medicine Department of OB/GYN Instructor
- 1990/08 - 1992/09 Vanderbilt University School of Medicine Center for Reproductive Biology Research Research Instructor
- 1988/04 - 1990/08 Case Western Reserve University School of Medicine Dept. of Physiology and Biophysics Postdoctoral Research Fellow/Research Associate
- 1983/04 - 1987/03 Yamagata University Graduate School of Medicine Dept. of OB/GYN and Immunology Doctoral course student
- 1986/02 - 1986/09 Hokkaido University Faculty of Veterinary Medicine Dept. of Biochemistry Visiting Scholar
- 1983/10 - 1984/03 Yamagata University Faculty of Science Dept. of Developmental Biology Visiting Scholar
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Committee career (10)：
- 2014/01 - 現在 Scientific Reports Editorial Board
- 2009 - 現在 Japanese Society for the History of Medicine Regular member
- 2005 - 現在 Society for Reproduction and Development Regular member
- 2004/04 - 現在 日本生殖免疫学会 評議員
- 1992 - 現在 Society for the Study of Reproduction Regular member
- 1986 - 現在 International Society for Immunology of Reproduction Regular member
- 1986 - 現在 Japanese Society of Immunology Regular member
- 1985 - 現在 Japan Society for Immunology of Reproduction Regular member
- 1985 - 現在 Japanese Society of Obstetrics and Gynecology Regular member
- 2007/01 - 2015/12 The Open Reproductive Science Journal Editorial Board
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Association Membership(s) (7)：
Society for the Study of Reproduction
, International Society for Immunology of Reproduction
, Japanese Society for the History of Medicine
, SOCIETY FOR REPRODUCTION AND DEVELOPMENT
, JAPAN SOCIETY FOR IMMUNOLOGY OF REPRODUCTION
, THE JAPANESE SOCIETY FOR IMMUNOLOGY
, JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY
