Research theme for competitive and other funds (21)：
2020 - 2025 Modification of somatosensory behaviors by intervention of glial cell subsets
2020 - 2025 Glia decoding: deciphering information critical for brain-body interactions
2019 - 2024 Elucidation of abnormal functioning of neuronal circuits underlying neuropathic pain and its application for drug discovery
2019 - 2021 New neuronal circuit for itch transmission in the spinal dorsal horn
2019 - 2020 Elucidation of abnormal functioning of neuronal circuits underlying neuropathic allodynia
2015 - 2019 Study for the mechanism underlying neuropathic pain focusing on a subpopulation of microglia
2015 - 2018 The underlying mechanism of glucocorticoid-regulated diurnal exacerbation of neuropathic pain hypersensitivity and its evaluation as a target of anti-allodynic drug
2015 - 2018 Roles of receptors for damage-associated molecular patterns on neuropathic pain
2014 - 2018 Establishment of research foundation on "objective pain assessment" using animal models suffering from neuropathic pain
2013 - 2018 Synaptic regulation by intracerebral microglia and chronic pain
2015 - 2017 A new approach for investigating the mechanism underlying chronic itch associated with atopic dermatitis
2012 - 2015 Exploration of analgesic target for tumor-induced neuropathic pain based on the molecular mechanism of circadian rhythm in allodynia
2012 - 2015 Roles of a newly identified pattern-recognition receptor family which activate innate immunity in development of neuropathic pain.
2011 - 2014 Study on the development of molecules for depressing neuropathic pain based on tertiary structure of human P2X4 receptor
2011 - 2011 ミクログリア転写因子IRF8を介する神経障害性疼痛発症維持メカニズム
2008 - 2010 Neuropathic pain-related molecules regulated by P2X4R in microglia
2006 - 2010 Research for the mechanism of the expression of neuropathic pain
2005 - 2007 難治性疼痛におけるグリア細胞活性化の分子的基盤
2003 - 2007 細胞外ATPを介したアストログリア-ニューロン相互調節機構の解明
2005 - 2006 難治性慢性疼痛時のミクログリアにおけるP2×4受容体発現増強分子の同定
2003 - 2005 The role of neuron-glia interaction in neuropathic pain
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Papers (246)：
Eiji Shigetomi, Hideaki Suzuki, Yukiho J. Hirayama, Fumikazu Sano, Yuki Nagai, Kohei Yoshihara, Keisuke Koga, Toru Tateoka, Hideyuki Yoshioka, Youichi Shinozaki, et al. Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2. Nature Communications. 2024. 15. 1
Ryoma Iwasaki, Yuta Kohro, Makoto Tsuda. A method for selective and efficient isolation of gray matter astrocytes from the spinal cord of adult mice. Molecular brain. 2024. 17. 1. 25-25
Kohei Nomaki, Risako Fujikawa, Takahiro Masuda, Makoto Tsuda. Spatiotemporal dynamics of the CD11c+ microglial population in the mouse brain and spinal cord from developmental to adult stages. Molecular brain. 2024. 17. 1. 24-24
Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Anthony E. Pickering, Hidemasa Furue. Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict. Communications Biology. 2024. 7. 1
Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Keiichiro Iida, Kenichi Kawaguchi, Yoshihiro Matsumoto, et al. Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. Scientific reports. 2023. 13. 1. 11177-11177
Society for Neuroscience
, THE JAPANESE BIOCHEMICAL SOCIETY
, 日本運動器疼痛研究会
, THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
, THE JAPAN NEUROSCIENCE SOCIETY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, JAPANESE ASSOCIATION FOR THE STUDY OF PAIN
, THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
, THE JAPANESE PHARMACOLOGICAL SOCIETY
