Akanuma Shin-ichi

Affiliation and department：
Job title： Associate Professor

Research field (1)： Clinical pharmacy

Research keywords (3)： Blood-retinal barrier , Blood-brain barrier , Pharmaceutics

Research theme for competitive and other funds (14)：

2022 - 2025 Transport mechanisms of cell-penetrating peptides at the blood-retinal barrier to establish strategies of macromolecular drug delivery
2020 - 2023 血液精巣関門インフラックス輸送機構の解明と精巣内薬物送達への応用
2019 - 2022 Establishing ex vivo methods to elucidate efflux transport of drugs at the blood-retinal barrier for retinal drug development
2017 - 2020 Study of cationic drug efflux across the blood-retinal barrier
2016 - 2019 The foundation of developing drugs for retinal diseases by pharmaceutical drug-repositioning screening based on the distribution manner via the blood-retinal barrier

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Papers (100)：

Takeru Ito, Yoshiyuki Kubo, Yuma Tega, Shin-Ichi Akanuma, Ken-Ichi Hosoya. Blood-to-Testis Transport of Ribavirin Involves Carrier-Mediated Processes at the Blood-Testis Barrier. Journal of pharmaceutical sciences. 2024
Ryuta Jomura, Masaru Sawada, Yuma Tega, Shin-Ichi Akanuma, Masanori Tachikawa, Ken-Ichi Hosoya. Molecular Mechanism of SLC6A8 Dysfunction with c.1699T > C (p.S567P) Mutation in Cerebral Creatine Deficiency Syndromes. Biological & pharmaceutical bulletin. 2024. 47. 1. 187-191
Yuma Tega, Toshinari Takeuchi, Masatoshi Nagano, Reina Makino, Yoshiyuki Kubo, Shin-Ichi Akanuma, Ken-Ichi Hosoya. Characterization of LysoTracker Red uptake by in vitro model cells of the outer blood-retinal barrier: Implication of lysosomal trapping with cytoplasmic vacuolation and cytotoxicity. Drug metabolism and pharmacokinetics. 2023. 51. 100510-100510
Yuma Tega, Yoshiyuki Kubo, Hiroaki Miura, Kairi Ri, Ayaka Tomise, Shin-Ichi Akanuma, Ken-Ichi Hosoya. Carrier-Mediated Process of Putrescine Elimination at the Rat Blood-Retinal Barrier. International journal of molecular sciences. 2023. 24. 10
Yusuke Shinozaki, Yuma Tega, Shin-Ichi Akanuma, Ken-Ichi Hosoya. The Structural Characteristics of Compounds Interacting with the Amantadine-Sensitive Drug Transport System at the Inner Blood-Retinal Barrier. Pharmaceuticals (Basel, Switzerland). 2023. 16. 3

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MISC (11)：

Yoshiyuki Kubo, Masakazu Yamamoto, Kensuke Matsunaga, Shin-Ichi Akanuma, Ken-Ichi Hosoya. INVOLVEMENT OF PLASMA MEMBRANE MONOAMINE TRANSPORTER (PMAT/SLC29A4) IN RETINA-TO-BLOOD TRANSPORT OF MPP plus ACROSS THE BLOOD-RETINAL BARRIER. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S100-S101
Takuya Usui, Yoshiyuki Kubo, Shin-ichi Akanuma, Ken-ichi Hosoya. INVOLVEMENT OF PMAT IN HISTAMINE EFFLUX FROM THE CEREBROSPINAL FLUID ACROSS THE BLOOD-CEREBROSPINAL FLUID BARRIER. DRUG METABOLISM REVIEWS. 2015. 47. 291-292
Yuma Tega, Shin-ichi Akanuma, Yoshiyuki Kubo, Ken-ichi Hosoya. NICOTINE TRANSPORT IN THE RAT BLOOD-BRAIN BARRIER AND LIVER: INVOLVEMENT OF THE PROTON-COUPLED ORGANIC CATION ANTIPORTER. DRUG METABOLISM REVIEWS. 2015. 47. 294-294
Yoshiyuki Kubo, Ai Tsuchiyama, Yoshimi Shimizu, Shin-ichi Akanuma, Ken-ichi Hosoya. THE BLOOD-TO-RETINA TRANSPORT OF CLONIDINE AT THE INNER BLOOD-RETINAL BARRIER. DRUG METABOLISM REVIEWS. 2015. 47. 292-293
赤沼伸乙, 久保義行, 細谷健一. タウリンの体内動態とその動態にトランスポーターが果たす役割 (特集第1回国際タウリン研究会日本部会プロシーディングス). タウリンリサーチ = Japanese journal of taurine research. 2015. 1. 1. 44-46

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Education (4)：

Professional career (1)：

Work history (4)：

2021/10 - 現在 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Associate Professor
2019/10 - 2021/09 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Assistant Professor
2007/10 - 2019/09 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research Assistant Professor
2015/05 - 2016/03 University of Kentucky Department of Pharmaceutical Sciences Visiting Scholar

Committee career (3)：

Awards (8)：

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Association Membership(s) (6)：

Society for Neuroscience , 日本DDS学会 , 日本薬物動態学会 , 日本薬剤学会 , 日本薬学会 , International Brain Barriers Society

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