2020 - 2022 Development of fail-safe system for human iPSC-derived tumor by CAR-T cell therapyCAR-T cell therapy
2019 - 2022 Functional analysis of novel immune checkpoints and development of combined immunotherapy in gynecological cancer
2019 - 2022 Development of TIL culture method for tumor infiltrating T cell therapy for cervical cancer
2018 - 2021 Evaluation of the role of beta-catenin pathway in human melanoma in anti-cancer immune responses
2019 - 2020 脂質代謝経路を標的としたがん免疫療法の探索
2015 - 2018 Development of a novel molecular targeted therapy against acral melanomas
2015 - 2018 Identification of the sub-population in human malignant melanoma showing strong resistance to tumor specific cytotoxic T cells
2013 - 2016 Investigating cancer-immunoescape mechanism and effective immuunotherapy for ovarian cancer
2013 - 2015 Systematic analysis of cellular signaling involved in the melanoma induced immunosuppression
2012 - 2015 Expression and Functional Analysis of HOXD9 in Cervical Cancer
2012 - 2015 Elucidation of the condition of construction mechanisms of immunity on sentinel lymph nodes of patients with melanoma and development of novel immunotherapy
2013 - 2015 Enhancement of anti-tumor immune responses by EGFR-TKIs (EGFR- tyrosin kinase inhibitors)
2011 - 2014 Development of effective immunotherapy by combining interventions on key points in the anti-tumor immune network
2011 - 2012 Investigation of roles of miRNA in the immunosuppression and clinical use for patients with melanoma
2011 - 2012 The role of Histatin-1 ectopically expressed in human melanoma cells
2009 - 2010 Elucidation of the mechanism of immunosuppression by mesenchymal stem cells in cancer microenvironments
2008 - 2009 癌シグナル伝達異常による、消化器癌の免疫逃避機構の解明と克服法の開発
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Papers (66)：
Kenta Nakamura, Tomonori Yaguchi, Masashi Murata, Yosuke Ota, Asuka Mikoshiba, Yukiko Kiniwa, Ryuhei Okuyama, Yutaka Kawakami. Tumor eradication by triplet therapy with BRAF inhibitor, TLR 7 agonist, and PD-1 antibody for BRAF-mutated melanoma. Cancer science. 2024. 115. 9. 2879-2892
Toshihiro Sugi, Yuki Katoh, Toshikatsu Ikeda, Daichi Seta, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Daiki Kato, Kanoko Katoh, Kei Kawana, et al. SCD1 inhibition enhances the effector functions of CD8+ T cells via ACAT1-dependent reduction of esterified cholesterol. Cancer science. 2023. 115. 1. 48-58
Kenji Chamoto, Tomonori Yaguchi, Masaki Tajima, Tasuku Honjo. Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1. Nature reviews. Immunology. 2023. 23. 10. 682-695
Takashi Kurosaki, Kenji Chamoto, Shinichiro Suzuki, Hiroaki Kanemura, Seiichiro Mitani, Kaoru Tanaka, Hisato Kawakami, Yo Kishimoto, Yasuharu Haku, Katsuhiro Ito, et al. The combination of soluble forms of PD-1 and PD-L1 as a predictive marker of PD-1 blockade in patients with advanced cancers: a multicenter retrospective study. Frontiers in immunology. 2023. 14. 1325462-1325462
レーザーがん免疫療法と光線力学療法(PDT)の融合を探る
(Laser Week V in Kyoto (第45 回日本レーザー医学会総会, 第34 回日本光線力学学会, 第20 回日本脳神経外科光線力学学会 3 学会合同開催) 2024)
がん免疫微小環境の多様性
(第4回京都大学がん免疫勉強会 2024)
ヒト腫瘍免疫学の重要性
(臨床免疫学会主催Midwinder seminar 2024 2024)
抗GPC1 scFv-Fc fusionタンパクを用いたGPC1発現評価(Anti-GPC1 scFv-Fc fusion protein as a detection tool of GPC1 expression in human cell lines and tissues)
(日本癌学会総会記事 2023)
HNF1betaを治療標的とした卵巣明細胞癌における新規複合的免疫療法の確立(Establishment of novel combination mmunotherapy by targeting HNF-1beta in ovarian clear cell carcinoma)
(日本癌学会総会記事 2023)
2020/01 - 現在 Kyoto University Department of Immunology and Genomic Medicine, Graduate School of Medicine
2016/04 - 2019/12 Keio University School of Medicine Institute for Advanced Medical Research (Division of Cellular Signaling)
2009/04 - 2016/03 Keio University School of Medicine Institute for Advanced Medical Research (Division of Cellular Signaling)
2008/04 - 2009/03 日本学術振興会特別研究員(DC2)
2003/04 - 2005/04 慶應義塾大学病院 内科 研修医
Awards (3)：
2015/09 - 日本免疫学会 平成27年度 Tadamitsu Kishimoto International Travel Award
2013/12 - 公益財団法人 東京生化学研究会 平成25年度 研究奨励金
2012/07 - 日本がん免疫学会 若手研究奨励賞
Association Membership(s) (5)：
The Japanese Society of Internal Medicine
, The Japanese Society of Clinical Immunology
, Japanese Society for Immunology
, Japanese cancer association
, Japanese Association of Cancer Immunology
