Koike-Kumagai Makiko

Research theme for competitive and other funds (2)：

2022 - 2025 血液脳関門を介さない皮膚から脳への新規薬剤輸送機構の解明
2021 - 2024 Elucidation of the cause of phenotypic differences in tuberous sclerosis complex using model mice

Papers (11)：

Fumiki Yamashita, Makiko Koike-Kumagai, Manabu Fujimoto, Mari Wataya-Kaneda. Somatostatin-expressing inhibitory neurons with mTORC1 activation in cortical layers 4/5 are involved in the epileptogenesis of mice. Exploration of Neuroscience. 2024. 3. 6. 527-538
Makiko Koike-Kumagai, Manabu Fujimoto, Mari Wataya-Kaneda. Sex-based differences in neuropsychiatric symptoms are due to estradiol/ERα-dependent transcriptional regulation via the modulation of steroid levels by sirolimus. Pharmacology, biochemistry, and behavior. 2024. 173875-173875
Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex. Journal of Experimental Neurology. 2022. 3. 2
Makiko Koike-Kumagai, Manabu Fujimoto, Mari Wataya-Kaneda. Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice. Neuropharmacology. 2022. 218. 109203-109203
Sonoko Hasegawa, Hiroaki Kobayashi, Makiko Kumagai, Hiroshi Nishimaru, Etsuko Tarusawa, Hiro Kanda, Makoto Sanbo, Yumiko Yoshimura, Masumi Hirabayashi, Takahiro Hirabayashi, et al. Clustered Protocadherins Are Required for Building Functional Neural Circuits. Frontiers in molecular neuroscience. 2017. 10. 114-114

ｍore...

MISC (4)：

WANG Weining, KATO Kiyoko, MAEDA Shinichiro, KOIKE-KUMAGAI Makiko, KITAYAMA Kazuko, FUJIMOTO Manabu, WATAYA-KANEDA Mari. Effect of rapamycin on skin hydration in mouse model of tuberous sclerosis complex. 日本研究皮膚科学会年次学術大会・総会プログラム. 2019. 44th. 225-225
榎本和生, 小池(熊谷) 牧子. ニューロン受容領域のタイル化を制御するリン酸化シグナルネットワーク:ショウジョウバエ感覚神経系をモデルとした解析-The kinase signaling network regulating establishment and maintenance of dendritic tiling: lessons from Drosophila sensory neurons. 細胞工学 = Cell technology. 2007. 26. 7. 806-810
OMaiko Furuta, Shinao Kose, Makiko Koike, Takeshi Shimi, Yasushi Hiraoka, Yoshihiro Yoneda, Toqko Haraguchi, Naoko Imamoto. Mechanism of stress-induced down regulation of importin alpha/beta transport pathway. CELL STRUCTURE AND FUNCTION. 2004. 29. 66-66
今本尚子, 小池牧子, 古田満衣子. 【細胞内輸送研究の最前線】核-細胞質間輸送の制御機構核-細胞質間輸送の分子機構と輸送経路の多様性. 実験医学. 2003. 21. 14. 1842-1849

Lectures and oral presentations (3)：

Brain estrogen levels are associated with gender differences in neuropsychiatric symptoms in mouse model of tuberous sclerosis complex, and sirolimus may contribute to symptom alleviation by controlling neurosteroid levels.
(The 2024 SID Annual Meeting,)
Epilepsy and TAND in the tuberous sclerosis complex are caused by an alteration in microglial polarity to M1 and sirolimus cures them by returning microglial polarity to M2.
(The 2023 International TSC Research Conference,)
Sirolimus alters microglial polarity leading to improvement of neuropsychiatric symptoms of tuberous sclerosis complex mice model.
(1 st. International Conference of Neuroscience and Neurology. Hybrid event in Dubai, UAE 2023)

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