Hinoi Takao

ヒノイタカオ | Hinoi Takao

Affiliation and department：
Job title： Professor

Research field (1)： Tumor diagnostics and therapeutics

Research keywords (6)： Surgical Oncology , Medical Oncology , Cancer Genetics , Genetic Counseling , Hereditary Cancer Syndrome , Cancer Genome Medicine

Research theme for competitive and other funds (7)：

2021 - 2025 Identification of the novel driver genes in drug-resistance colorectal cancers and the development of treatment
2018 - 2021 Establishment of mouse models and organoids corresponding to colorectal cancer molecular subtypes and their clinical application
2015 - 2017 Establishment of new colon cancer animal model using CRISPR / CAS 9 genome editing system
2013 - 2017 Establishment of a novel mouse colon cancer disease model with different genome instability useful for subclass classification
2013 - 2015 Investigation of metastasis related genes based on conditinoal knock out mouse model

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Papers (196)：

Haruki Sada, Takao Hinoi, Hiroaki Niitsu, Hideki Ohdan, Seiichiro Yamamoto, Shungo Endo, Koya Hida, Yusuke Kinugasa, Toshiyuki Enomoto, Satoshi Maruyama, et al. Right-sided versus left-sided colorectal cancer in elderly patients: a sub-analysis of a large multicenter case-control study in Japan. Surgery today. 2024
Tomohiro Adachi, Manabu Shimomura, Hiroyuki Egi, Wataru Shimizu, Yuji Takakura, Shoichiro Mukai, Masatoshi Kochi, Masanori Yoshimitsu, Takao Hinoi, Hideki Ohdan. Clinical Phase I Study of TAS102/Irinotecan/Bevacizumab Combination Therapy in Japanese Patients With Unresectable Metastatic Colorectal Cancer (mCRC). Cureus. 2023. 15. 12. e50431
Tetsu Hirakawa, Mihoko Doi, Kosuke Hamai, Ryo Katsura, Shinya Miyake, Suguru Fujita, Sayaka Ueno, Ken Masuda, Takuya Tanimoto, Takashi Nishisaka, et al. Comprehensive genomic profiling of Japanese patients with thoracic malignancies: A single-center retrospective study. Respiratory investigation. 2023. 61. 6. 746-754
Takafumi Fukushima, Keisuke Goto, Tetsutaro Hayashi, Kenichiro Ikeda, Tomoya Hatayama, Ryoken Yamanaka, Kyosuke Iwane, Ryo Tasaka, Yuki Kohada, Kenshiro Takemoto, et al. Comprehensive genomic profiling testing in Japanese castration-resistant prostate cancer patients: results of a single-center retrospective cohort study. Japanese journal of clinical oncology. 2023
Haruki Sada, Hiroyuki Sawada, Masakazu Tokunaga, Manabu Shimomura, Hiroyuki Egi, Minoru Hattori, Hiroki Ohge, Hideki Ohdan, Takao Hinoi. Clinical efficacy of Daikenchuto (DKT: TJ-100) for gastrointestinal symptoms in patients with a history of colon and rectosigmoid cancer surgery: a randomized crossover study. Surgery today. 2023. 53. 8. 873-881

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MISC (28)：

河内雅年, 檜井孝夫, 斎藤保文, 新津宏明, 佐田春樹, 坂本直也, 仙谷和弘, 大上直秀, 安井弥, 大段秀樹. BRAF遺伝子の下流に位置し大腸癌の増殖に関与する遺伝子Xの解析. 日本癌学会総会記事. 2020. 79回. PJ4-1
丸山諒太, 坂本直也, 谷山大樹, 常國健太, 本間りりの, 鵜飼翔一, 檜井孝夫, 大段秀樹, 安井弥. 大腸癌オルガノイドを用いたトリフルリジンの効用の検討. 日本癌学会総会記事. 2020. 79回. PJ11-4
檜井孝夫, 斉藤保文, 新津宏明, 河内雅年, 佐田春樹, 田代裕尊, 大段秀樹. 新規大腸上皮細胞特異的複合的遺伝子改変マウスモデルによる大腸癌ドライバー遺伝子の機能解析と新規バイオマーカーの同定. 日本消化器病学会雑誌. 2020. 117. 臨増総会. A318-A318
Yuji Takakura, Katsunori Shinozaki, Satoshi Ikeda, Hiroyuki Egi, Yuzo Hirata, Manabu Shimomura, Takafumi Oshiro, Takao Hinoi, Daisuke Sumitani, Masahiro Nakahara, et al. Pre- versus postoperative CAPOX plus bevacizumab (CAPOX-Bev) for resectable liver metastases from colorectal cancer (CLM): A randomized phase II/III trial (HiSCO-01). JOURNAL OF CLINICAL ONCOLOGY. 2020. 38. 15
久保田晴菜, 首藤毅, 清水洋祐, 兒島正人, 赤羽慎太郎, 三隅俊博, 羽田野直人, 田澤宏文, 清水亘, 鈴木崇久, et al. 区域性肝内胆管の拡張を呈した大腸癌肝転移の2例. 癌と化学療法. 2019. 46. 3. 537-539

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