Rchr
J-GLOBAL ID:201801017854250572   Update date: Jan. 31, 2024

Kousho Wakae

Kousho Wakae
Affiliation and department:
Research field  (4): Medical biochemistry ,  Virology ,  Tumor biology ,  Molecular biology
Research keywords  (6): interferon ,  EB virus ,  Hepatitis Virus ,  APOBEC ,  Human Papillomavirus ,  tumor virus
Research theme for competitive and other funds  (8):
  • 2022 - 2024 ヒトHBVキメラ ゲノム量に着目した、肝臓癌の新規再発 マーカーの開発
  • 2021 - 2022 SARS-CoV-2 の 宿主ゲノムへの挿入を考慮した、 COVID-19 PCR 検査法の改良
  • 2017 - 2019 APOBECを介したHPV発癌機序の解明と発癌予測因子としての応用
  • 2014 - 2017 Role of APOBEC deaminases in human tumor virus infection
  • 2014 - 2017 遺伝子改変酵素群APOBECはHPV感染における発癌因子か?
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Papers (49):
  • Kento Fukano, Kousho Wakae, Naganori Nao, Masumichi Saito, Akihito Tsubota, Takae Toyoshima, Hideki Aizaki, Hiroko Iijima, Takahiro Matsudaira, Moto Kimura, et al. A versatile method to profile hepatitis B virus DNA integration. Hepatology Communications. 2023
  • Haruyo Aoyagi, Hiroko Iijima, Eman S Gaber, Takuma Zaitsu, Mami Matsuda, Kosho Wakae, Koichi Watashi, Ryosuke Suzuki, Takahiro Masaki, Jeffrey Kahn, et al. Hepatocellular organellar abnormalities following elimination of hepatitis C virus. Liver international : official journal of the International Association for the Study of the Liver. 2023. 43. 8. 1677-1690
  • Takeo Matsumoto, Takuma Suzuki, Mitsuhiro Nakamura, Megumi Yamamoto, Takashi Iizuka, Masanori Ono, Kyosuke Kagami, Haruki Kasama, Tatsuhito Kanda, Yuya Sakai, et al. Androgen promotes squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3-dependent pathway. Cancer medicine. 2023. 12. 9. 10816-10828
  • Takeo Matsumoto, Takashi Iizuka, Mitsuhiro Nakamura, Takuma Suzuki, Megumi Yamamoto, Masanori Ono, Kyosuke Kagami, Haruki Kasama, Kousho Wakae, Masamichi Muramatsu, et al. FOXP4 inhibits squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3-dependent pathway. Cancer science. 2022. 113. 10. 3376-3389
  • Hirotomo Dochi, Satoru Kondo, Takayuki Murata, Masaki Fukuyo, Asuka Nanbo, Kousho Wakae, Wen-Ping Jiang, Toshihide Hamabe-Horiike, Mariko Tanaka, Takumi Nishiuchi, et al. Estrogen induces the expression of EBV lytic protein ZEBRA, a marker of poor prognosis in nasopharyngeal carcinoma. Cancer science. 2022. 113. 8. 2862-2877
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MISC (8):
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Lectures and oral presentations  (5):
  • APOBEC3s mutate Merkel cell polyomavirus genome in Merkel cell carcinoma
    (2021)
  • EBV LMP1はß3の発現を誘導し、ミトコンドリアDNA変異を惹起する.
    (第43回日本分子生物学会年会 2020)
  • Epstein-Barr virus LMP1 alters expression profiles of APOBEC3s
    (2019)
  • Epstein-Barr virus LMP1 alters expression profiles of APOBEC3s, and hypermutates mitochondrial DNA in nasopharyngeal cells
    (DNA tumor virus meeting 2019 2019)
  • APOBEC3 hypermutates mitochondrial DNA in HPV16-positive keratinocytes
    (第65回日本ウイルス学会学術集会 2017)
Education (2):
  • 2008 - 2012 京都大学大学院 医学研究科
  • 2000 - 2006 Kyoto University Faculty of Medicine Department of Medical Science
Work history (3):
  • 2018/07 - 現在 国立感染症研究所 ウイルス第二部 主任研究官
  • 2012/05 - 2018/06 金沢大学大学院・医薬保健研究域 分子遺伝学 助教
  • 2006/04 - 2008/03 京都大学医学部付属病院 臨床研修医
Association Membership(s) (4):
日本肝臓学会 ,  日本癌学会 ,  THE JAPANESE SOCIETY FOR VIROLOGY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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