Iikuni Shimpei

Affiliation and department：

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research theme for competitive and other funds (5)：

2022 - 2024 がん免疫療法の治療効果予測に資する新規パーフォリンイメージング法の開発
2020 - 2023 レビー小体病の診断・治療に資するαシヌクレイン標的核医学イメージング法の開発
2019 - 2021 Development of coumarin-based theranostic agents targeting carbonic anhydrase-IX
2016 - 2019 診断・治療を融合するTheranostics用多機能低分子キレート医薬品の開発
2014 - 2017 Development of nuclear medical imaging probes targeting cerebral amyloid antipathy

Papers (49)：

Sho Kaide, Hiroyuki Watanabe, Shimpei Iikuni, Masato Hasegawa, Masahiro Ono. Synthesis and Evaluation of 18F-Labeled Chalcone Analogue for Detection of α-Synuclein Aggregates in the Brain Using the Mouse Model. ACS chemical neuroscience. 2022. 13. 20. 2982-2990
Kazuma Nakashima, Shimpei Iikuni, Hiroyuki Watanabe, Masahiro Ono. Application of the Chelator-Based Clickable Radiotheranostic Platform to Moderate-Molecular-Weight Ligands. ACS medicinal chemistry letters. 2022. 13. 10. 1642-1647
Shimpei Iikuni, Yuta Tarumizu, Shohei Tsuchihashi, Takaki Ohara, Hiroyuki Watanabe, Masahiro Ono. Synthesis and Evaluation of Novel ¹¹¹In-Labeled Picolinic Acid-Based Radioligands Containing an Albumin Binder for Development of a Radiotheranostic Platform. Molecular Pharmaceutics. 2022. 19. 8. 2725-2736
Shimpei Iikuni, Takaki Ohara, Hiroyuki Watanabe, Masahiro Ono. Structure-Activity Relationships and Pharmacokinetics of ¹¹¹In-Labeled Glucagon-like Peptide-1 Receptor-Targeting Exendin-4 Derivatives Conjugated with Albumin Binder Moieties. Molecular Pharmaceutics. 2022. 19. 8. 2832-2839
Takahiro Akasaka, Hiroyuki Watanabe, Sho Kaide, Shimpei Iikuni, Masato Hasegawa, Masahiro Ono. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorganic & medicinal chemistry letters. 2022. 64. 128679-128679

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MISC (57)：

北野杏奈, 飯國慎平, 渡邊裕之, 玉田太郎, 小野正博. Development of nuclear medicine imaging probe targeting granzyme B to predict effect of immune checkpoint inhibitors: synthesis and evaluation of novel radioiodine-labeled tetrapeptides. 日本薬学会年会要旨集(Web). 2021. 141st
渡邊裕之, 左海汐梨, 志水陽一, 飯國慎平, 白川久志, 金子周司, 小野正博. 多発性硬化症の画像診断を目的としたミエリン標的SPECTイメージングプローブの開発. 核医学. 2020. 57. Suppl. S152-S152
安藤正登, 志水陽一, 飯國慎平, 渡邊裕之, 小野正博. 99mTc標識2価リガンドを容易に調製可能とするHydroxamamide母核二官能性キレート剤の開発. 核医学. 2020. 57. Suppl. S152-S152
中島一磨, 飯國慎平, 岡田祐哉, 渡邊裕之, 志水陽一, 小野正博. 炭酸脱水酵素IXを標的とした新規68Ga標識化合物の合成と評価. 核医学. 2020. 57. Suppl. S172-S172
岡田祐哉, 飯國慎平, 渡邊裕之, 志水陽一, 小野正博. 腎集積低減を目指した炭酸脱水酵素IXを標的とする放射性金属錯体の合成と評価. 日本薬学会年会要旨集. 2020. 140年会. 26I-pm18S

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