Iikuni Shimpei

Affiliation and department：

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research theme for competitive and other funds (4)：

2020 - 2023 レビー小体病の診断・治療に資するαシヌクレイン標的核医学イメージング法の開発
2019 - 2021 クマリンを基盤とした炭酸脱水酵素IX標的がんセラノスティクス用薬剤の開発
2016 - 2019 診断・治療を融合するTheranostics用多機能低分子キレート医薬品の開発
2014 - 2017 Development of nuclear medical imaging probes targeting cerebral amyloid antipathy

Papers (45)：

Shimpei Iikuni, Yuta Tarumizu, Shohei Tsuchihashi, Takaki Ohara, Hiroyuki Watanabe, Masahiro Ono. Synthesis and Evaluation of Novel ¹¹¹In-Labeled Picolinic Acid-Based Radioligands Containing an Albumin Binder for Development of a Radiotheranostic Platform. Molecular Pharmaceutics. 2022. 19. 8. 2725-2736
Shimpei Iikuni, Takaki Ohara, Hiroyuki Watanabe, Masahiro Ono. Structure-Activity Relationships and Pharmacokinetics of ¹¹¹In-Labeled Glucagon-like Peptide-1 Receptor-Targeting Exendin-4 Derivatives Conjugated with Albumin Binder Moieties. Molecular Pharmaceutics. 2022. 19. 8. 2832-2839
Takahiro Akasaka, Hiroyuki Watanabe, Sho Kaide, Shimpei Iikuni, Masato Hasegawa, Masahiro Ono. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorganic & medicinal chemistry letters. 2022. 64. 128679-128679
Shimpei Iikuni, Ichiro Kamei, Takaki Ohara, Hiroyuki Watanabe, Masahiro Ono. Development of an ¹¹¹In-Labeled Glucagon-Like Peptide-1 Receptor-Targeting Exendin-4 Derivative that Exhibits Reduced Renal Uptake. Molecular Pharmaceutics. 2022. 19. 3. 1019-1027
Kosuke Saito, Hiroyuki Watanabe, Shimpei Iikuni, Masahiro Ono. Development of novel 67/68Ga-labeled pyridyl benzofuran derivatives as islet amyloid imaging probes. Nuclear Medicine and Biology. 2022. 106-107. 72-79

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MISC (57)：

北野杏奈, 飯國慎平, 渡邊裕之, 玉田太郎, 小野正博. Development of nuclear medicine imaging probe targeting granzyme B to predict effect of immune checkpoint inhibitors: synthesis and evaluation of novel radioiodine-labeled tetrapeptides. 日本薬学会年会要旨集(Web). 2021. 141st
渡邊裕之, 左海汐梨, 志水陽一, 飯國慎平, 白川久志, 金子周司, 小野正博. 多発性硬化症の画像診断を目的としたミエリン標的SPECTイメージングプローブの開発. 核医学. 2020. 57. Suppl. S152-S152
安藤正登, 志水陽一, 飯國慎平, 渡邊裕之, 小野正博. 99mTc標識2価リガンドを容易に調製可能とするHydroxamamide母核二官能性キレート剤の開発. 核医学. 2020. 57. Suppl. S152-S152
中島一磨, 飯國慎平, 岡田祐哉, 渡邊裕之, 志水陽一, 小野正博. 炭酸脱水酵素IXを標的とした新規68Ga標識化合物の合成と評価. 核医学. 2020. 57. Suppl. S172-S172
岡田祐哉, 飯國慎平, 渡邊裕之, 志水陽一, 小野正博. 腎集積低減を目指した炭酸脱水酵素IXを標的とする放射性金属錯体の合成と評価. 日本薬学会年会要旨集. 2020. 140年会. 26I-pm18S

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