Rchr
J-GLOBAL ID：201801018124547541   Update date: Feb. 01, 2024

Ishimaru Yuki

イシマル ユウキ | Ishimaru Yuki
Affiliation and department：
Setsunan University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences

About Setsunan University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences


Job title： Junior Associate Professor
Homepage URL  (1)： https://gyoseki.setsunan.ac.jp/html/100001117_ja.html
Research field  (3)： Neuroscience - general ,  Ophthalmology ,  Pharmacology
Research keywords  (7)： Glaucoma ,  Diabetes ,  Apelin ,  Neuroprotection ,  Neuronal cell death ,  Angiogenesis ,  Retina
Research theme for competitive and other funds  (12)：
  • 2022 - 2025 Preventive effect of intermittent fasting against diabetic retinopathy and its mechanism
  • 2019 - 2022 A study on apelin receptor agonists as a new medicine for the treatment of glaucoma
  • 2019 - 2021 Apelin receptor agonists as a new therapeutic agent for diabetic retinopathy
  • 2016 - 2019 A study on apelin as a new therapeutic target for diabetic retinopathy
  • 2015 - 2018 A study on apelin as a new therapeutic target for glaucoma using apelin deficiency mouse
Show all
Papers (19)：
  • Akiko Yamamuro-Tanabe, Yasuhiro Kosuge, Yuki Ishimaru, Yasuhiro Yoshioka. Schwann cell derived-peroxiredoxin protects motor neurons against hydrogen peroxide-induced cell death in mouse motor neuron cell line NSC-34. Journal of Pharmacological Sciences. 2023. 153. 2. 73-83
  • Akiko Yamamuro-Tanabe, Yurika Mukai, Wataru Kojima, Siyuan Zheng, Naoko Matsumoto, Shoho Takada, Mao Mizuhara, Yasuhiro Kosuge, Yuki Ishimaru, Yasuhiro Yoshioka. An Increase in Peroxiredoxin 6 Expression Induces Neurotoxic A1 Astrocytes in the Lumbar Spinal Cord of Amyotrophic Lateral Sclerosis Mice Model. Neurochemical Research. 2023
  • Yasuhiro Yoshioka, Yuta Sugino, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda. Dopamine inhibits the expression of proinflammatory cytokines of microglial cells through the formation of dopamine quinone in the mouse striatum. Journal of Pharmacological Sciences. 2022. 148. 1. 41-50
  • Yuki Ishimaru, Fumiya Shibagaki, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda. Protective effect of apelin-APJ system against retinal neurodegeneration in diabetic model mice fed a high-fat diet. Jpn J Ocul Pharmacol. 2021. 35. 1. 94-97
  • Yuki Ishimaru, Yasuhiro Yoshioka, Sadaaki Maeda. The apelin-APJ system as a therapeutic target for the early diabetic retinopathy. The cell. 2021. 53. 5. 313-316
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MISC (13)：
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Patents (1)：
  • 網膜神経保護作用を有するアペリン受容体アゴニストを含有する医薬組成物
Lectures and oral presentations  (177)：
  • Endogenous apelin is protective against retinal dysfunction in type 1 diabetic Akita mice
    (2022)
  • 培養神経細胞における高グルコース負荷による酸化的ストレス誘発細胞死の促進
    (日本薬学会第140年会 2021)
  • アストロサイトにおけるペルオキシレドキシン6の発現増加が炎症性サイトカイン産生および GLT-1 発現に及ぼす影響
    (日本薬学会第141年会 2021)
  • 培養神経細胞における酸化的ストレス誘発細胞死に対する高グルコースによる促進作用
    (第94回日本薬理学会年会 2021)
  • 血管内皮細胞株 bEnd.3 細胞におけるアペリンによる終末糖化産物誘発細胞死抑制作用
    (第94回日本薬理学会年会 2021)
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Education (2)：
  • 2009 - 2011 Setsunan University Graduate School, Division of Pharmaceutical Sciences
  • 2005 - 2009 Setsunan University Faculty of Pharmaceutical Science
Professional career (1)：
  • 博士(薬学) (摂南大学)
Work history (2)：
  • 2022/04 - 現在 Setsunan University Faculty of Pharmaceutical Sciences Junior Associate Professor
  • 2011/04 - 2022/03 Setsunan University Faculty of Pharmaceutical Sciences Assistant Professor
Committee career (2)：
  • 2022/04 - 現在 日本口腔ケア学会 評議員
  • 2019/04 - 現在 日本薬理学会 学術評議員
Association Membership(s) (6)：
日本口腔ケア学会 ,  The International Society for Neurochemistry ,  Japanese Journal of Ocular Pharmacology ,  The Japanese Society for Neurochemistry ,  The Pharmaceutical Society of Japan ,  The Japanese Pharmacological Society
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