Rchr
J-GLOBAL ID:201801018186487251   Update date: Aug. 07, 2024

Nishiyama Akihito

Nishiyama Akihito
Affiliation and department:
Homepage URL  (1): https://www.med-niigatauniv-bacteriol.org
Research field  (1): Bacteriology
Research keywords  (2): tuberculosis ,  bacteriology
Research theme for competitive and other funds  (8):
  • 2022 - 2028 天然変性蛋白質(IDP)を標的とする、中分子化合物による、新しい創薬フィールドの開拓
  • 2024 - 2027 結核菌天然変性蛋白質-核酸凝集の分子機序の解明と核酸医薬への応用
  • 2019 - 2022 結核の発病予測向上と治療期間 短縮を目指した生物学的要因の 探索(研究分担者)
  • 2017 - 2020 細菌における天然変性蛋白質のヒストンコード機構による形質制御の証明
  • 2016 - 2019 結核菌の潜在化機構の解析と、潜在化の維持による結核制圧戦略の構築
Show all
Papers (69):
  • Yuriko Ozeki, Akira Yokoyama, Akihito Nishiyama, Yutaka Yoshida, Yukiko Ohara, Tsukasa Mashima, Chikako Tomiyama, Amina K Shaban, Atsuki Takeishi, Mayuko Osada-Oka, et al. Recombinant mycobacterial DNA-binding protein 1 with post-translational modifications boosts IFN-gamma production from BCG-vaccinated individuals' blood cells in combination with CpG-DNA. Scientific reports. 2024. 14. 1. 9141-9141
  • Ikkoh Yasuda, Naomi Ruth D. Saludar, Ana Ria Sayo, Shuichi Suzuki, Akira Yokoyama, Yuriko Ozeki, Haruka Kobayashi, Akihito Nishiyama, Sohkichi Matsumoto, Sharon E. Cox, et al. Evaluation of cytokine profiles related to Mycobacterium tuberculosis latent antigens using a whole-blood assay in the Philippines. Frontiers in Immunology. 2024. 15
  • Atsuki Takeishi, Amina K. Shaban, Taichi Kakihana, Hayato Takihara, Shujiro Okuda, Hidekazu Osada, Desak Nyoman Surya Suameitria Dewi, Yuriko Ozeki, Yutaka Yoshida, Akihito Nishiyama, et al. Genetic engineering employing MPB70 and its promoter enables efficient secretion and expression of foreign antigen in bacillus Calmette Guérin (BCG) Tokyo. Microbiology and Immunology. 2024
  • Akihito Nishiyama, Masahiro Shimizu, Tomoyuki Narita, Noriyuki Kodera, Yuriko Ozeki, Akira Yokoyama, Kouta Mayanagi, Takehiro Yamaguchi, Mariko Hakamata, Amina Kaboso Shaban, et al. Dynamic action of an intrinsically disordered protein in DNA compaction that induces mycobacterial dormancy. Nucleic acids research. 2023
  • Yutaka Yoshida, Akihito Nishiyama, Desak Nyoman Surya Suameitria Dewi, Tomoya Yamazaki, Akira Yokoyama, Daiki Kobayashi, Hitoshi Kondo, Yuriko Ozeki, Sohkichi Matsumoto. Limited proteolysis of mycobacterial DNA-binding protein 1 with an extended, lysine-rich, intrinsically disordered region to unveil posttranslational modifications. Biochemical and Biophysical Research Communications. 2023. 681. 111-119
more...
MISC (41):
  • 山崎 智也, 石川 智史, 田村 敏生, 塚本 裕美子, Nyoman Desak, 吉田 豊, 尾関 百合子, 西山 晃史, 立石 善隆, 松本 壮吉. 野生型結核菌抗原を用いた抗体検出による活動性結核の診断と発症予測法の検討. 日本細菌学雑誌. 2023. 78. 1. 69-69
  • 阿部透, 若松のぞみ, 西山晃史, 立石善隆, 松本壮吉, 上田大次郎, 佐藤努. Identification of a new type of enzyme that reduces E- and Z-isoprene units. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
  • 阿部透, 袴田真理子, 西山晃史, 立石善隆, 松本壮吉, 邊見久, 上田大次郎, 佐藤努. Functional analysis of a new type of Z, E-mixed prenyl reductase from mycobacteria. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
  • 阿部透, 若松のぞみ, 西山晃史, 立石善隆, 松本壮吉, 上田大次郎, 佐藤努. E-及びZ-イソプレンユニットを還元する新しいタイプの酵素の同定. イソプレノイド研究会例会講演要旨集. 2022. 32nd
  • 袴田真理子, 袴田真理子, 瀧原速仁, 岩本朋忠, 岩本朋忠, 田丸亜貴, 尾関百合子, 西山晃史, 立石善隆, 菊地利明, et al. GENOME ANALYSIS OF MYCOBACTERIUM TUBERCULOSIS BEIJING STRAINS ISOLATED FROM EARLY-ONSET AND LONG TERM LATENT POST-ONSET. 結核(Web). 2021. 96. 3
more...
Books (4):
  • BCG 2nd Edition -TB vaccine- Application against tuberculosis and other diseases
    Japan Anti-Tuberculosis Association (JATA) 2022
  • 病原微生物学 基礎と臨床
    東京化学同人 2014
  • 病原菌の今日的意味 改訂4版
    医薬ジャーナル社 2011
  • MRSA -基礎・臨床・対策-
    医薬ジャーナル社 2010
Lectures and oral presentations  (24):
  • 抗酸菌の天然変性ヒストン様蛋白質 -その機能と休眠菌形成における役割-
    (第99 回日本結核・非結核性抗酸菌症学会学術講演会 2024)
  • Dynamic action of an intrinsically disordered histone-like protein in DNA compaction that induces mycobacterial dormancy
    (The U.S.-Japan Cooperative Medical Sciences Program: Mycobacterial Diseases Panel Meeting 2024 2024)
  • 抗酸菌の天然変性ヒストン様タンパク質 -その機能と休眠菌形成における役割-
    (日本生物物理学会第61回年会 2023)
  • 抗酸菌の休眠誘導に関わる天然変性ヒストン様タンパク質によるDNA凝集の動的メカニズムの解析
    (第23回日本蛋白質学科学年会 2023)
  • 抗酸菌ヒストン様タンパク質は天然変性領域を介して核酸との相分離を誘導する
    (第96回日本細菌学会総会 2023)
more...
Education (3):
  • 2000 - 2003 Tohoku University Graduate School of Agricultural Science Department of Molecular and Cellular Biology
  • 1998 - 2000 Tohoku University Graduate School of Agricultural Science Department of Molecular and Cellular Biology
  • 1994 - 1998 Tohoku University Faculty of Agriculture Applied Biological Chemistry
Professional career (1):
  • 博士(農学) (東北大学)
Work history (4):
  • 2010/07 - 現在 Niigata University Department of Bacteriology, School of Medicine Lecturer
  • 2007/03 - 2010/06 Niigata University Department of Bacteriology, School of Medicine Assistant Professor
  • 2003/09 - 2007/01 Florida Atlantic University Charles E. Schmidt College of Biomedical Sciences Research Associate
  • 2003/06 - 2003/09 East Carolina University Department of Physiology, the Brody School of Medicine Research Associate
Association Membership(s) (3):
American Society for Microbiology ,  JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY ,  JAPANESE SOCIETY FOR BACTERIOLOGY
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