Rchr
J-GLOBAL ID：201801018316206217   Update date: Jun. 21, 2025

nishida yuya

ニシダ ユウヤ | nishida yuya
Affiliation and department：
National Cerebral and Cardiovascular Center, Research Institute Molecular Pharmacology

About National Cerebral and Cardiovascular Center, Research Institute Molecular Pharmacology


Job title： Laboratory Chief
Homepage URL  (2)： https://ncvc-molpharm.jp/ ,  https://ncvc-molpharm.jp/en/
Research field  (3)： Pharmaceuticals - chemistry and drug development ,  Molecular biology ,  Structural biochemistry
Research keywords  (7)： 化合物スクリーニング ,  cryoEM / single particle analysis ,  biochemistry ,  hem-copper oxide reductase ,  cytochrome c oxidase ,  Thermus ,  X-ray crystal structure analysis
Research theme for competitive and other funds  (8)：
  • 2025 - 2028 デザインされたタンパク質を用いた呼吸鎖複合体IVの活性増強と創薬応用
  • 2025 - 2026 酸素消費を制御する新規心不全治療法の開発
  • 2024 - 2025 進化的に隠されたアロステリーを利用した特異的阻害剤
  • 2023 - 2025 進化的に隠されたアロステリック部位の探索方法確立と抗菌薬開発への展開
  • 2022 - 2023 新規アロステリーによる特異的抗菌薬の合理的創出
Show all
Papers (14)：
  • Eman Elrefaei, Satoru Yamazaki, Issei Yazawa, Yusuke Takahashi, Naoki Ito, Nozomi Hayashiji, Yuya Nishida, Ichizo Nishino, Seiji Takashima, Yasunori Shintani. LSMEM2, Localized at the Neuromuscular Junction, Modulates Mitochondrial Integration in Skeletal Muscles. The FASEB Journal. 2025. 39. 12
  • Tasneem Qaqorh, Yusuke Takahashi, Kohei Sameshima, Kentaro Otani, Issei Yazawa, Yuya Nishida, Kohei Tonai, Yoshitaka Fujihara, Mizuki Honda, Shinya Oki, et al. Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by spatial and single-cell transcriptomics. Science advances. 2025. 11. 14. eadq1575
  • Yutaka Yokota, Sachiko Kadowaki, Satoru Yamazaki, Yuya Nishida, Toshiaki Shishido, Shuji Shimizu, Shingo Kasahara, Yasuhiro Kotani. Expression of c-jun/c-fos mRNA Indicates Persistent Myocardial Stretch During Asphyxia-Induced Cardiac Arrest. International Heart Journal. 2024. 65. 5. 939-944
  • Yuya Nishida, Sachiko Yanagisawa, Rikuri Morita, Hideki Shigematsu, Kyoko Shinzawa-Itoh, Hitomi Yuki, Satoshi Ogasawara, Ken Shimuta, Takashi Iwamoto, Chisa Nakabayashi, et al. Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases. Nature Communications. 2022. 13. 1. 7591-7591
  • Masaru Kato, Ryoya Sano, Narumi Yoshida, Masatoshi Iwafuji, Yoshito Nishiyama, Sayuki Oka, Kyoko Shinzawa-Itoh, Yuya Nishida, Yasunori Shintani, Ichizo Yagi. Effects of Interfacial Interactions on Electrocatalytic Activity of Cytochrome c Oxidase in Biomimetic Lipid Membranes on Gold Electrodes. The Journal of Physical Chemistry Letters. 2022. 13. 39. 9165-9170
ｍore...
MISC (5)：
Books (2)：
  • ミトコンドリア疾患治療の新時代 : オルガネラ動態を紐解き異常ミトコンドリアの標的分子を狙う!
    羊土社 2023 ISBN:9784758104098
  • ヘムタンパク質の科学 : 生理機能の理解とその展開に向けて
    エヌ・ティー・エス 2022 ISBN:9784860437787
Lectures and oral presentations  (2)：
  • 呼吸鎖複合体IVの隠されたアロステリック阻害機構と抗菌薬開発への展開
    (第94回 SPring-8 先端利用技術ワークショップ 2023)
  • Evolutionally conserved allostery in heme-copper oxidases can generate pathogen-specific antibiotics
    (21th European Bioenergetics Conference 2022)
Education (2)：
  • Osaka University Graduate School of Frontier Biosciences
  • Osaka University School of Science
Professional career (1)：
  • Sc.D. (Osaka University)
Work history (4)：
  • 2023/04 - 現在 National Cerebral and Cardiovascular Center, Research Institute Molecular Pharmacology
  • 2019/06 - 2023/03 National Cerebral and Cardiovascular Center, Research Institute Molecular Pharmacology
  • 2017/04 - 2019/05 大阪大学大学院 医学系研究科 特任助教
  • 2015/04 - 2017/03 大阪大学大学院 医学系研究科 特任研究員
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