Shirogane Yuta

シロガネユウタ | Shirogane Yuta

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.researchgate.net/profile/Yuta-Shirogane

Research field (1)： Virology

Research keywords (20)： measles virus , Subacute sclerosing panencephalitis, SSPE , enveloped virus , membrane fusion , cis-acting receptor , evolution , Sociovirology , en bloc transmission , Cooperation , poliovirus , defective interference , mathematical modelling , human metapneumovirus , mumps virus , cis-acting fusion triggering , RNA virus , interference , Virus-virus interaction , quasispecies , virus

Research theme for competitive and other funds (13)：

2024 - 2028 膜融合過程で紐解くウイルス感染の複雑系
2022 - 2027 シス受容体が解明する麻疹ウイルス中枢神経病原性発揮メカニズム
2022 - 2027 側頭骨扁平上皮癌の悪性度を決定するエピジェネティックな腫瘍制御機構の解明
2023 - 2026 モルビリウイルス感染症の理解と対策のための研究開発
2023 - 2026 膜融合タンパク質がもたらす多様なエンベロープウイルス進化ポテンシャルの解明

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Papers (27)：

Ryuichi Takemoto, Yuichi Hirai, Shumpei Watanabe, Hidetaka Harada, Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi, Yuta Shirogane. Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein. Journal of Virology. 2023. 97. 5. e0034023
Yuta Shirogane, Hidetaka Harada, Yuichi Hirai, Ryuichi Takemoto, Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi. Collective fusion activity determines neurotropism of an en bloc transmitted enveloped virus. Science Advances. 2023. 9. 4. eadf3731
Ryuichi Takemoto, Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi, Yuta Shirogane. Short-Stalk Isoforms of CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Interacting with the Viral Hemagglutinin. Journal of Virology. 2022. 96. 3. e0194921
Yinghong Xiao, Peter V Lidsky, Yuta Shirogane, Ranen Aviner, Chien-Ting Wu, Weiyi Li, Weihao Zheng, Dale Talbot, Adam Catching, Gilad Doitsh, et al. A defective viral genome strategy elicits broad protective immunity against respiratory viruses. Cell. 2021. 184. 25. 6037-6051
Yuta Shirogane, Elsa Rousseau, Jakub Voznica, Yinghong Xiao, Weiheng Su, Adam Catching, Zachary J Whitfield, Igor M Rouzine, Simone Bianco, Raul Andino. Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome. PLoS pathogens. 2021. 17. 9. e1009277

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MISC (10)：

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Lectures and oral presentations (31)：

ウイルス膜融合の鍵としての生体分子の新展開
(第97回日本生化学会大会 2024)
Accumulating Mutations in Fusion Proteins of Measles Virus SSPE Isolates Enable CADM1/2-Independent Membrane Fusion
(2024)
A Mutation in Measles Virus Hemagglutinin Enhances Fusion between Neurons
(2024)
Intrahost Evolution of Measles Virus: A Pathway to Fatal Brain Disease
(The 22nd Awaji International Forum on Infection and Immunity 2024)
麻疹ウイルス亜急性硬化性全脳炎(SSPE)研究から浮かび上がるウイルス進化のダイバーシティ
(第44回阿蘇シンポジウム 2024)

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Education (3)：

2003 - 2013 Kyushu University School of Medicine MD-PhD program
2007 - 2011 九州大学大学院医学研究院博士課程病態医学専攻ウイルス学分野(柳雄介教授)
2000 - 2003 福岡県立福岡高等学校

Professional career (1)：

博士(医学) (九州大学)

Work history (7)：

2024/10 - 現在 Institute of Science Tokyo Graduate School of Medical and Dental Sciences Professor
2024/05 - 2024/09 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Professor
2023/12 - 2024/04 Kyushu University
2018/04 - 2023/11 Kyushu University
2016/05 - 2018/03 University of California, San Francisco

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Committee career (1)：

2023/04 - 2023/09 九州大学医系分野教員会執行委員長

Awards (3)：

2023/09 - Young Researchers Excellent Presentation How Mutations in Measles Virus Glycoproteins Can Cause Severe Neurological Disease
2022/11 - The Japanese Society of Virology Sugiura award Pathogenicity, Evolution, and Interaction of RNA Viruses
2011/03 - 日本学生支援機構特に優れた業績による大学院第一種奨学生返還免除の認定(全額免除)

Association Membership(s) (4)：

日本神経感染症学会 , American Society of Microbiology , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR VIROLOGY

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