Rchr
J-GLOBAL ID:201801018333869114   Update date: Jun. 19, 2021

TAKAHASHI-KANEMITSU Atsushi

タカハシ アツシ (カネミツ アツシ) | TAKAHASHI-KANEMITSU Atsushi
Affiliation and department:
Job title: Research associate
Homepage URL  (2): http://www.microbiol.m.u-tokyo.ac.jp/https://www.researchgate.net/profile/Atsushi_Takahashi-Kanemitsu
Research field  (3): Cell biology ,  Molecular biology ,  Tumor biology
Research keywords  (8): Genetically engineered mouse model ,  Organoid ,  Signal transduction ,  Epithelial cell polarity ,  Protein phosphorylation ,  CagA ,  Helicobacter pylori ,  Cancer
Research theme for competitive and other funds  (6):
  • 2019 - 2022 Understanding of the Mechanism of Gastric Carcinogenesis by the Development of the System that Visualizes Dynamics of the Planar Cell Polarity within Gastric Epithelial Organoids
  • 2015 - 2017 Investigation of the Medical/Biological Roles of the Parafibromin Functions Regulated by SHP2 Oncoprotein
  • 2014 - 2015 In vivo Analysis on Oncogenesis in Tg Mice Expressing Dephosphorylated Parafibromin
  • 2010 - 2015 Host Response as an Enhancer of Infection-associated Cancer and its Regulation
  • 2012 - 2014 Investigation of the Roles of Dephosphorylated Parafibromin by SHP2 in Oncogenesis
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Papers (12):
  • Imai S, Ooki T, Murata-Kamiya N, Komura D, Tahmina K, Wu W, Takahashi-Kanemitsu A, Knight C T, Kunita A, Suzuki N, et al. Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis. Cell Host & Microbe. 2021. 29. 1-18
  • Ben C, Wu X, Takahashi-Kanemitsu A, Knight C T, Hayashi T, Hatakeyama M. Alternative splicing reverses the cell-intrinsic and cell-extrinsic prooncogenic potentials of YAP1. Journal of Biological Chemistry. 2020. 295. 41. 13965-13980
  • Takahashi-Kanemitsu A, Knight C T, Hatakeyama M. Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis. Cellular & Molecular Immunology. 2020. 17. 50-63
  • Ooki T, Murata-Kamiya N, Takahashi-Kanemitsu A, Wu W, Hatakeyama M. High-molecular-weight hyaluronan is a Hippo pathway ligand directing cell density-dependent growth inhibition via PAR1b. Developmental Cell. 2019. 49. 1-15
  • Tang C, Takahashi-Kanemitsu A, Kikuchi I, Ben C, Hatakeyama M. Transcriptional co-activator functions of YAP and TAZ are inversely regulated by tyrosine phosphorylation status of Parafibromin. iScience. 2018. 1. 1-15
more...
MISC (4):
Lectures and oral presentations  (39):
  • The regulation of the morphogenic signaling pathways by SHP2 protein tyrosine phosphatase
    (Seminar 2021)
  • Alternative splicing confers non-cell-autonomous tumorigenic activities to YAP1
    (The 79th Annual Meeting of the Japanese Cancer Association 2020)
  • Perturbation of non-canonical Wnt/Planer Cell Polarity signaling by the Helicobacter pylori CagA oncoprotein
    (The 78th Annual Meeting of the Japanese Cancer Association 2019)
  • Activation of the tumor suppressive Hippo pathway by high-molecular-weight hyaluronan and its breakdown in breast cancer
    (The 78th Annual Meeting of the Japanese Cancer Association 2019)
  • Inverse control of transcription co-activator function of YAP and TAZ by tyrosine phosphorylation status of Parafibromin
    (The 77th Annual Meeting of the Japanese Cancer Association 2018)
more...
Education (4):
  • 2009 - 2011 The University of Tokyo (Visiting Student)
  • 2006 - 2011 Hokkaido University (Doctor Course) Institute for Genetic Medicine
  • 2004 - 2006 Hokkaido University (Master Course) Institute for Genetic Medicine
  • 2000 - 2004 Hokkaido University (Bachelor Course) Division of Chemistry
Professional career (1):
  • Ph. D. in Science (Hokkaido University)
Work history (3):
  • 2013/04 - 現在 The University of Tokyo Division of Microbiology, Graduate School of Medicine Research Associate
  • 2011/10 - 2013/03 The University of Tokyo Division of Microbiology, Graduate School of Medicine Postdoctoral Researcher
  • 2007/04 - 2009/03 @Hokkaido University Japan Society for the Promotion of Science Research Fellow (DC2)
Awards (3):
  • 2014 - The Uehara Memorial Foundation Research Grant for Young Scientists In vivo Analysis on Oncogenesis in Tg mice expressing dephosphorylated Parafibromin
  • 2011 - Japanese Association for Protein Phosphatase Research Annual Research Award for Young Scientists “SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver.”
  • 2007 - Japan Society for the Promotion of Science Research Fellowship for Young Scientists “Comprehensive Analysis of Intracellular Substrates for SHP2 Tyrosine Phospatase”
Association Membership(s) (3):
Japanese Association for Protein Phosphatase Research ,  The Molecular Biology Society of Japan ,  The Japanese Cancer Association
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