Rchr
J-GLOBAL ID：201801018403203976
Update date: Oct. 02, 2024
Sakaue Fumika
サカウエ フミカ | Sakaue Fumika
Affiliation and department：
Research field (2)：
Neuroscience - general
, Molecular biology
Research keywords (1)：
Neuroscience
Research theme for competitive and other funds (3)：
- 2024 - 2027 Oligonucleotide targeting TDP-43 protein as a new therapeutic strategy for sporadic amyotrophic lateral sclerosis (ALS)
- 2021 - 2022 Development of Oligonucleotide thrapeutics that Improve the Phenotypes of ALS Model Mice
- 2020 - 2021 Exploration of novel mucopolysaccharidosis therapeutic agent that can be delivered to the central nervous system
Papers (20)：
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Juri Hasegawa, Tetsuya Nagata, Kensuke Ihara, Jun Tanihata, Satoe Ebihara, Kie Yoshida-Tanaka, Mitsugu Yanagidaira, Masahiro Ohara, Asuka Sasaki, Miyu Nakayama, et al. Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model. Nature Communications. 2024. 15. 1
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Motoki Miura, Fumika Sakaue, Hirokazu Matsuno, Kento Morita, Akiko Yoshida, Rintaro Iwata Hara, Ren Nishimura, Yurika Nishida, Mariko Yokogawa, Masanori Osawa, et al. TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate. FEBS Letters. 2023
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Ken Asada, Fumika Sakaue, Tetsuya Nagata, Ji-Chun Zhang, Kie Yoshida-Tanaka, Aya Abe, Makiko Nawa, Kazutaka Nishina, Takanori Yokota. Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing. Nucleic acids research. 2021. 49. 9. 4864-4876
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Daisuke Ono, Ken Asada, Daishi Yui, Fumika Sakaue, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota. Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking. Molecular Therapy - Nucleic Acids. 2021. 23. 1360-1370
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Koji Matsuhisa, Longjie Cai, Atsushi Saito, Fumika Sakaue, Yasunao Kamikawa, Sachiko Fujiwara, Rie Asada, Yukitsuka Kudo, Kazunori Imaizumi. Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells. Brain research. 2020. 1749. 147139-147139
ｍore...
MISC (1)：
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黒岩伸明, 坂上史佳, 三浦元輝, 松野弘和, 永田哲也, 横田隆徳. Exploration of the intracellular aptamer that inhibits aggregation of ALS-associated protein FUS. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2022. 7th
Books (6)：
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Emerging trends in ALS clinical trials
2024
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実験医学増刊 いま新薬で加速する神経変性疾患研究
2023 ISBN:9784758104128
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NEURO LOGICA
2021
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Annual review神経 2018
中外医学社 2018 ISBN:9784498328068
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完全版マウス・ラット疾患モデル活用ハンドブック : 表現型,遺伝子情報,使用条件など
羊土社 2011 ISBN:9784758120173
ｍore...
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