Nakata Masanobu

ナカタマサノブ | Nakata Masanobu

Affiliation and department：
Job title：教授

Research field (1)： Oral medicine (pathology)

Research theme for competitive and other funds (34)：

2024 - 2027 ビタミンDによるセロトニンや腸内細菌叢を介した覚醒時ブラキシズムの治療効果の検討
2023 - 2026 歯周病原因細菌の口腔から全身への定着に関与する因子の研究
2022 - 2026 RNAサーモセンサーとタンパク質重合体を介するレンサ球菌感染機構の探索
2022 - 2025 口腔内の病原性共生細菌に対する一本鎖可変断片の創生と応用
2022 - 2025 プロバイオティクスが覚醒時ブラキシズムと顎関節症に及ぼす影響の解明

2020 - 2023 一細胞解析による肺炎球菌感染時の宿主転写応答の解明

2020 - 2023 歯周病原因菌の病原性因子及び挿入配列を制御するsmall RNAの解析

2019 - 2022 Molecular mechanisms underlying streptococcal infections for development of preventive and therapeutic measures

2019 - 2021 Investigation of novel infection control strategy based on bacterial evolutional information

2017 - 2021 Infection by oral mitis group streptococci induces impairment of mast cell function and allergic response

2018 - 2020 Exploration of a novel dissemination route for development of therapeutic strategies against bacterial meningitis

2017 - 2020 Streptococcal translocation across epithelial barrier via tricellular junction

2016 - 2020 Molecular epidemiological analysis of Streptococcus pneumoniae in Southeast Asian countries

2019 - 2020 細菌における新規翻訳制御機構の探索

2017 - 2019 レンサ球菌のニッチ拡大に伴う宿主-菌体相互作用の解析

2016 - 2019 レンサ球菌が産生する線毛の付着機能と発現機構の解析

2016 - 2018 Role of streptococcal arginie deiminase in the evasion of host immunity

2015 - 2018 Exploration of streptococcal factors related with onset of bacteremia and systemic dissemination

2017 - 2018 菌体表層に存在する線維状タンパク質重合体の会合と抗原性がもたらす病原性の探索

2014 - 2017 Pathogenicity of hydrogen peroxide produced by oral streptococci

2014 - 2017 Analysis of streptococcal translocation across epithelial barrier via paracellular route

2014 - 2016 Analysis of ornithine rhamnolipid-like pigment from oral bacteria

2012 - 2015 Exploration of bacterial factors that inactivate complement regulatory factors and induce invasive infectious diseases

2012 - 2014 Dvelopment of novel adjuvant which constructed by DNA origami technology

2012 - 2014 Role of cyclodextrin in oral bacteria-associated systemic illness

2011 - 2014 Multi-dimensional analyses of a novel immune system NETs-inducer using nano live imaging technology

2011 - 2013 Analysis of virulence regulatory mechanism of group A streptococcal ncRNA

2009 - 2010 Searching for environmental signals sensed by group A streptococcal two-component systems

2009 - 2010 レンサ球菌のmicroRNAがヒト組織に及ぼす病原性のオーソログ検索

2008 - 2010 Functional analysis of adhesins and colonization factors produced by human pathogenic streptococci

2006 - 2010 Molecular analysis of bacterial invasion strategies and intracellular growth of pathogenic streptococci

2007 - 2008 Analysis of the function of streptococcal heamolysin

2007 - 2008 Group A streptococcal proteases degrade human complements and contribute to evasion of innate immunity

2006 - 2007 Protective immunity against group Astreptococcus infection following immunization with fibronectin-binding proteins

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Papers (63)：

Yuki Takahara, Tomoko Sumitomo, Masamitsu Kono, Moe Takemura, Yukako Akamatsu, Yujiro Hirose, Masaya Yamaguchi, Masanobu Nakata, Muneki Hotomi, Shigetada Kawabata. Pneumolysin contributes to dysfunction of nasal epithelial barrier for promotion of pneumococcal dissemination into brain tissue. mSphere. 2024
Dalia Talat, Tomoko Sumitomo, Mariko Honda-Ogawa, Yuki Takahara, Yasushi Mori, Masaya Yamaguchi, Masanobu Nakata, Madiha S. Ibrahim, Shigetada Kawabata. Two-component regulatory system TCS08 of a serotype 4 strain in pneumococcal pneumonia pathogenesis. Journal of Oral Biosciences. 2024
Katsuki Takebe, Mamoru Suzuki, Takeshi Sangawa, Bernd Kreikemeyer, Masaya Yamaguchi, Narikazu Uzawa, Tomoko Sumitomo, Shigetada Kawabata, Masanobu Nakata. Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms. Archives of Microbiology. 2023. 206. 1
武部克希, 鈴木守, 東孝太郎, 山口雅也, 住友倫子, 川端重忠, 中田匡宣. Streptococcus sanguinisが産生する線毛タンパク質のX線結晶構造解析. Journal of Oral Biosciences Supplement. 2023. 2023. [P1-25]
Seiko Kubota, Masanobu Nakata, Yujiro Hirose, Masaya Yamaguchi, Bernd Kreikemeyer, Narikazu Uzawa, Tomoko Sumitomo, Shigetada Kawabata. Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of messenger RNA level of transcriptional regulator. Microbiology and immunology. 2023. 67. 7. 319-333

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MISC (24)：

Yuichi Oogai, Masanobu Nakata. Small regulatory RNAs of oral streptococci and periodontal bacteria. Japanese Dental Science Review. 2021. 57. 209-216
東孝太郎, 東孝太郎, 山口雅也, 中田匡宣, 武部克希, 住友倫子, 鈴木守, 川端重忠. Structural analysis of Streptococcus pyogenes hyaluronidase and in silico analysis based on structural models. Journal of Oral Biosciences Supplement (Web). 2021. 2021
東孝太郎, 東孝太郎, 山口雅也, 中田匡宣, 中田匡宣, 武部克希, 住友倫子, 鈴木守, 川端重忠. 化膿レンサ球菌におけるヒアルロン酸分解酵素の分子系統解析および結晶構造解析. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
広瀬雄二郎, 山口雅也, 秋山徹, 竹本訓彦, 奥野ルミ, 山口貴弘, 大塚仁, 住友倫子, 中田匡宣, 川端重忠. Investigation of factors contributing to the invasiveness of Streptococcus pyogenes emm 89. 日本細菌学雑誌(Web). 2020. 75. 1
武部克希, 中田匡宣, 川端重忠, 鈴木守. Streptococcus sanguinisが産生するSrtCのX線結晶構造. 日本結晶学会年会講演要旨集. 2018. 2018

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Books (3)：

口腔微生物学・免疫学第4版
医歯薬出版 2016 ISBN:9784263457917
病原性レンサ球菌の病原因子の機能解析.
大阪大学出版会 2008
Streptococci and Streptococcal Diseases edited by Martin DR, and Tagg JR.Effects of receptor-globulins on invasive group A streptococcal infection.
Securacopy Press 2000

Awards (1)：

2015/07 - 大阪大学大阪大学総長奨励賞 2015

Association Membership(s) (3)：

American Society for Microbiology , JAPANESE ASSOCIATION FOR ORAL BIOLOGY , JAPANESE SOCIETY FOR BACTERIOLOGY

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