Okazaki Il-mi

Affiliation and department：

Research keywords (6)：免疫学 , 分子生物学 , がん免疫 , 免疫寛容 , 自己免疫 , 免疫補助受容体

Research theme for competitive and other funds (8)：

2022 - 2026 Regulatory mechanism of allergic disease development by inhibitory co-receptors
2019 - 2022 Elucidating molecular mechanisms of the regulation of immunodominance
2018 - 2020 Genetic analysis of autoimmune myocarditis
2015 - 2017 Regulatory mechanisms of autoimmunity by LAG-3 expressing cells
2009 - 2010 Roles of PD-1 and AIDA in inflammation-induced tumorigenesis.

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Papers (43)：

Takumi Maruhashi, Daisuke Sugiura, Il-mi Okazaki, Kenji Shimizu, Takeo K. Maeda, Jun Ikubo, Harunori Yoshikawa, Katsumi Maenaka, Naozumi Ishimaru, Hidetaka Kosako, et al. Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. Immunity. 2022
Daisuke Sugiura, Il-Mi Okazaki, Takeo K Maeda, Takumi Maruhashi, Kenji Shimizu, Rieko Arakaki, Tatsuya Takemoto, Naozumi Ishimaru, Taku Okazaki. PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. Nature immunology. 2022. 23. 3. 399-410
Daisuke Sugiura, Kenji Shimizu, Takumi Maruhashi, Il-Mi Okazaki, Taku Okazaki. T cell-intrinsic and -extrinsic regulation of PD-1 function. International immunology. 2021. 33. 12. 693-698
Kenji Shimizu, Daisuke Sugiura, Il-mi Okazaki, Takumi Maruhashi, Tatsuya Takemoto, Taku Okazaki. PD-1 preferentially inhibits the activation of low-affinity T cells. Proceedings of the National Academy of Sciences. 2021. 118. 35. e2107141118-e2107141118
Takumi Maruhashi, Daisuke Sugiura, Il-mi Okazaki, Taku Okazaki. LAG-3: from molecular functions to clinical applications. Journal for ImmunoTherapy of Cancer. 2020. 8. 2. e001014-e001014

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MISC (13)：

岡崎拓, 岡崎一美. 次世代抗体医薬の衝撃免疫寛容を標的とした抗体医薬によるがん免疫療法. 実験医学. 2018. 36. 11
Taku Okazaki, Il-mi Okazaki. Basic researches on cancer immunotherapy targeting inhibitory co-receptors. Journal of Clinical and Experimental Medicine. 2016. Vol.256. No.7. 789-792
Taku Okazaki, Il-mi Okazaki. Regulation of autoimmunity by PD-1. Experimental Medicine. 2015. Vol.33. No.12. 1935-1940
岡崎拓, 岡崎一美. 抑制性免疫補助受容体PD-1によるがんと自己免疫の制御. 生化学. 2015. 87. 6
Il-mi Okazaki, Taku Okazaki. 癌,自己免疫病とPD-1. Journal of Clinical and Experimental Medicine. 2013. Vol.245. No.3. 12353-12357

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Professional career (1)：

Work history (7)：

2019/11 - 現在東京大学定量生命科学研究所分子免疫学研究分野准教授
2012/08 - 2019/10 The University of Tokushima
2008/09 - 2012/08 Assistant Professor, Division of Immune Regulation, Institute for Genome Research, The University of Tokushima
2007/04 - 2008/08 Assistant Professor, Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University
2004/04 - 2007/03 JSPS research fellow (PD)

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