Rchr
J-GLOBAL ID:201801018694015101   Update date: Feb. 28, 2024

Koike Hiroyuki

コイケ ヒロユキ | Koike Hiroyuki
Affiliation and department:
Job title: Associate Professor
Homepage URL  (1): https://www.researchgate.net/profile/Hiroyuki-Koike-3
Research field  (3): Developmental biology ,  Medical biochemistry ,  Developmental biology
Research keywords  (10): Organoid ,  Single Cell Analysis ,  iPS Cells ,  Organogenesis ,  Aging ,  Liver ,  Macrophages ,  3D Cell Culture ,  Stem Cell Biology ,  Regenerative Medicine
Research theme for competitive and other funds  (10):
  • 2023 - 2026 疾患特異的iPS細胞を用いたケロイドの病態解明と治療法の確立
  • 2023 - 2026 Tokyo Medical and Dental University
  • 2022 - 2025 Establishment of a circulating culture system using the metabolic characteristics of organoids
  • 2021 - 2024 高度オルガノイド技術を利用した革新的がん遺伝子治療モデリングと腫瘍溶解性機構解明
  • 2021 - 2024 Single cell analysis for tissue regeneration and lipid metabolism in skeletal muscle
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Papers (29):
  • Yumiko Oishi, Hiroyuki Koike, Naoki Kumagami, Yoshimi Nakagawa, Masaya Araki, Yoshitaka Taketomi, Yoshimi Miki, Shigeru Matsuda, Takashi Matsuzaka, Hitoshi Ozawa, et al. Macrophage SREBP1 regulates skeletal muscle regeneration. Frontiers in Immunology. 2024. 14
  • Takahisa Matsuzaki, Yuma Kawano, Momoka Horikiri, Yuko Shimokawa, Takashi Yamazaki, Nao Okuma, Hiroyuki Koike, Masaki Kimura, Ryuzo Kawamura, Yosuke Yoneyama, et al. Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells. STAR Protocols. 2023. 4. 3. 102471-102471
  • Aiko Watanabe, Hiroyuki Koike, Naoki Kumagami, Shigeki Shimba, Ichiro Manabe, Yumiko Oishi. Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair. Scientific Reports. 2023. 13. 1. 6747
  • Rie Ouchi, Hiroyuki Koike. Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids. Frontiers in Cell and Developmental Biology. 2023. 11
  • Sumio Hayakawa, Atsushi Tamura, Nikita Nikiforov, Hiroyuki Koike, Fujimi Kudo, Yinglan Cheng, Takuro Miyazaki, Marina Kubekina, Tatiana V. Kirichenko, Alexander N. Orekhov, et al. Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling. JCI Insight. 2022. 7. 22
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MISC (42):
  • 大石 由美子, 小池 博之. フレイル、サルコペニアのバイオマーカー 加齢による筋損傷後再生不全のメカニズム. 日本老年医学会雑誌. 2022. 59. Suppl. 49-49
  • Hiroyuki Koike, Yumiko Oishi. Vitamin A derivative inhibits KLF5 function in the skeletal muscle atrophy pathogenesis. Experimental Medicine. 2022. 40. 7. 1027-1031
  • 小池 博之. 骨格筋再生を主導する多細胞間相互作用ネットワークの解析. 日本応用酵素協会誌. 2022. 56. 79-80
  • 渡辺 藍子, 小池 博之, 大石 由美子. 骨髄球系細胞が持つ細胞内時計の錯乱が筋再生に及ぼす影響. 日本筋学会学術集会プログラム・抄録集. 2021. 7回. 116-116
  • 佐藤 荘, 小池 博之, 伊藤 美菜子, 北岡 志保, 住田 智一, 増田 隆博. 生体恒常性および疾患を制御する間質細胞生物学. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [JB2-1]
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Patents (3):
Books (2):
  • Reviews in Cell Biology and Molecular Medicine
    Wiley-VCH Verlag 2016 ISBN:9783527305421
  • Hyper bio assembler for 3D cellular systems
    Springer Japan 2015 ISBN:9784431552963
Lectures and oral presentations  (64):
  • Cell-cell interactions of post-injury muscle regeneration and tissue repair
    (From basic discovery to preclinical modeling: at the forefront of muscle disease therapies 2023)
  • 加齢による筋損傷後再生不全のメカニズム
    (第64回日本老年医学会学術集会 2022)
  • Effects of disruption of the circadian rhythm in myeloid cells on skeletal muscle regeneration
    (The 7th Annual Meeting of Japan Muscle Society 2021)
  • SREBP1a in macrophage regulates tumor growth
    (The 44th Annual Meeting of the Molecular Biology Society of Japan 2021)
  • Diversity of skeletal muscle macrophages leading to regeneration and repair after muscle injury
    (The 44th Annual Meeting of the Molecular Biology Society of Japan 2021)
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Education (3):
  • 2010 - 2014 Yokohama City University Graduate School of Medicine Department of Regenerative Medicine
  • 2007 - 2009 Tohoku University Graduate School of Engineering Department of Biomolecular Engineering
  • 2003 - 2007 Tohoku University School of Engineering Department of Applied Chemistry
Professional career (1):
  • Ph.D. (Yokohama City University)
Work history (8):
  • 2023/07 - 現在 Tokyo Medical and Dental University Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences Associate Professor
  • 2022/04 - 2023/06 Nippon Medical School Department of Metabolism and Nutrition, Graduate School of Medicine Senior Assistant Professor
  • 2022/04 - 2023/06 Nippon Medical School Department of Biochemistry and Molecular Biology Senior Assistant Professor
  • 2019/04 - 2022/03 Nippon Medical School Department of Biochemistry and Molecular Biology Assistant Professor
  • 2018/03 - 2019/03 Tokyo Medical and Dental University Advanced Molecular Medicine, Medical Research Institute Assistant Professor
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Awards (8):
  • 2020/11 - The Takeda Science Foundation Medical Research Grant Analysis of cell-cell interactions leading to skeletal muscle regeneration using single-cell analysis
  • 2020/06 - Japan Foundation for Applied Enzymology TMFC Analysis of the multicellular interaction network that drives skeletal muscle regeneration
  • 2019/09 - Nippon Medical School Maruyama Memorial Research Award Elucidation of the regulatory mechanism of muscle regeneration by crosstalk between immune cells and skeletal muscle stem cells
  • 2018/09 - Tokyo Medical and Dental University President’s Young Researchers Award Construction of an in vitro skeletal muscle injury model that can analyze the tissue repair process
  • 2016/08 - Cincinnati Children’s Hospital Medical Center Core Values Award
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Association Membership(s) (2):
The Molecular Biology Society of Japan ,  Japanese Society of Anti-Aging Medicine
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