Uehara Shunsuke

ウエハラシュンスケ | Uehara Shunsuke

Affiliation and department：

Research field (1)： Oral medicine

Research theme for competitive and other funds (30)：

2023 - 2026 Identification of a calcium paradox factor through transcriptomic and secretomic analysis of osteoblasts
2022 - 2026 細胞種特異的老化モデル創出による老化細胞除去機構の解明と抗フレイル戦略の開拓
2022 - 2025 プロテインキナーゼN3の構造から探る破骨細胞機能制御機構と阻害剤の臨床応用
2021 - 2025 Anlysis of the RANKL-Siglec-15 signal molecular mechanism for alveolar bone regeneration
2020 - 2023 Elucidation of unknown network mechanism of osteoprotegerin in bone, cardiovascular and digestive system

2020 - 2023 幹細胞の分化を司る組織常在型M3マクロファージとそのマスター転写因子の同定

2019 - 2022 Elucidation of the role of sclerostin in growth and development process of bone

2019 - 2022 Elucidation of the molecular mechanism in the osteoclast function through protein kinase N3 and its clinical application.

2018 - 2021 Development of the new periodontal treatments based on the regulation of sclerostin secretion

2018 - 2021 Structure, function and physiological significance of vesicular polyamine transporter

2016 - 2021 Development of alveolar bone turnover control method based on Wnt signaling network

2017 - 2020 Analysis and clinical application of new function of osteoprotegerin as anti-aging factor

2016 - 2019 Elucidation of the mechanism of bone-resorption in osteoclasts regulated by Pkn3.

2016 - 2019 Applied research of periodontal disease therapeutics using osteogenic sugnal from osteoclasts

2015 - 2017 Did calcitonine appear as a central nerve hormone?

2013 - 2016 Elucidation of molecular mechanisms for osteoclast polarization through Wnt5a-Ror2 signaling

2013 - 2015 Exploration of seeds for development of a new drug targeting Bone-Vascular-Spleen axis

2012 - 2015 Analysis of bone remodeling mechanism between osteoblasts and osteoclasts for the alveolar bone regeneration

2013 - 2014 骨代謝共役を担うWntシグナルの解明

2012 - 2014 Do carbon nanotubes control bone remodeling?

2011 - 2012 Regulatory mechanism of actin-ring formation through Wnt5a-Ror2 signaling pathway in osteoclasts

2010 - 2011 Role of Wnt-Ror2 signals in ruffled border formation in osteoclasts

2009 - 2011 Basic research on development of new treatment of alveolar bone regeneration

2009 - 2010 Elucidation of regulatory mechanism of bone metabolism by Wnts secreted from osteoclasts.

2008 - 2010 Development of methodology for the hard tissue regeneration using dental pulp cells

2008 - 2009 破骨細胞が分泌する新規骨形成誘導因子の同定

2007 - 2008 骨吸収抑制因子としてのプロスタグランジンE2の作用解析

2007 - 2008 Elucidation of the mechanism of new retinoid X receptor ligand action in the enhancement of bone volume in vivo.

2007 - 2008 Elucidation of the regulated mechanism of bone metabolism by osteoclastic transcytosis.

2006 - 2007 破骨細胞によるトランスサイトーシスを介したグルタミン酸分泌の制御機構と意義の解明

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Papers (99)：

中村美どり, 宇田川信之, 小出雅則, 上原俊介, 山下照仁, 小林泰浩. シアル酸受容体タンパク質Siglec-15中和抗体の破骨細胞と骨芽細胞に対する作用(Effects of sialic acid receptor protein Siglec-15 neutralizing antibody on osteoclasts and osteoblasts). Journal of Oral Biosciences Supplement. 2022. 2022. 359-359
松井龍一, 上原俊介, 宇田川信之, 小林泰浩, 石田昌義. 骨芽細胞分化における細胞老化の影響(Effect of cellular senescence on osteoblast differentiation). Journal of Oral Biosciences Supplement. 2022. 2022. 178-178
Shunsuke Uehara, Hideyuki Mukai, Teruhito Yamashita, Masanori Koide, Kohei Murakami, Nobuyuki Udagawa, Yasuhiro Kobayashi. Inhibitor of protein kinase N3 suppresses excessive bone resorption in ovariectomized mice. Journal of bone and mineral metabolism. 2022. 40. 2. 251-261
Eisuke Tsuda, Chie Fukuda, Akiko Okada, Tsuyoshi Karibe, Yoshiharu Hiruma, Nana Takagi, Yoshitaka Isumi, Tomomaya Yamamoto, Tomoka Hasegawa, Shunsuke Uehara, et al. Characterization, pharmacokinetics, and pharmacodynamics of anti-Siglec-15 antibody and its potency for treating osteoporosis and as follow-up treatment after parathyroid hormone use. Bone. 2022. 155. 116241-116241
松井龍一, 石田昌義, 上原俊介, 宇田川信之, 吉成伸夫, 小林泰浩. 細胞老化の骨芽細胞分化に対する影響. 松本歯学. 2021. 47. 2. 192-193

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MISC (32)：

松下雅衣, 小出雅則, 芳澤享子, 堀部寛治, 小林泰浩, 山下照仁, 中道裕子, 上原俊介, 宇田川信之. Long-term observation of sclerostin expression in BMP-induced ectopic bone. Journal of Oral Biosciences Supplement (Web). 2020. 2020
村上康平, 宇田川信之, 上原俊介, 小出雅則, 山下照仁, 小林泰浩. WntアンタゴニストSfrp5は破骨細胞の分化を抑制し、骨芽細胞の分化を促進する. 日本骨代謝学会学術集会プログラム抄録集. 2019. 37回. 199-199
小林泰浩, 上原俊介. 【運動器を構成する骨・軟骨・関節・筋肉・靱帯・腱のトピック】破骨細胞に関する最新のトピック破骨細胞の骨吸収機能発現におけるWntシグナルの役割. THE BONE. 2019. 33. 1. 23-28
小林泰浩, 上原俊介, 小出雅則. 【Wntシグナルと骨】Wntシグナルによる破骨細胞の制御. Clinical Calcium. 2019. 29. 3. 309-315
宇田川信之, 宇田川信之, 小出雅則, 山下照仁, 中村美どり, 中村美どり, 上原俊介, 小林泰浩, 高橋直之. 破骨細胞の骨形成シグナルにおける重要性. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd

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Education (3)：

Professional career (1)：

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