Sunagawa Yoichi

Affiliation and department：
Other affiliations (1)：

京都医療センター展開医療研究部研究員

Research field (3)： Molecular biology , Cardiology , Pharmaceuticals - health and biochemistry

Research keywords (6)： Nuclear Signaling pathway , Nobiletin , Curcumin , 天然化合物 , 心血管疾患 , 分子生物学

Research theme for competitive and other funds (9)：

2023 - 2026 The studyon of p300 complex on cardiac hypertrophy and fibrosis during the development of heart failure
2023 - 2026 ノックインマウスを用いた心不全によるGATA4多量体形成の変化並びに治療薬の探索研究
2020 - 2023 Identification and functional analysis of p300 regulatory factors involved in the development of heart failure using medical proteomics
2019 - 2022 The study of functional mechanism of Nobiletin, which possess the therapeutic potency for development of heart failure.
2017 - 2019 Development of novel therapeutic method for heart failure targeted on PRMT5/MEP50 complex

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Papers (194)：

Yasufumi Katanasaka, Harumi Yabe, Noriyuki Murata, Minori Sobukawa, Yuga Sugiyama, Hikaru Sato, Hiroki Honda, Yoichi Sunagawa, Masafumi Funamoto, Satoshi Shimizu, et al. Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice. Nature communications. 2024. 15. 1. 2472-2472
Yoichi Sunagawa, Ryosuke Tsukabe, Yudai Irokawa, Masafumi Funamoto, Yuto Suzuki, Miho Yamada, Satoshi Shimizu, Yasufumi Katanasaka, Toshihide Hamabe-Horiike, Yuto Kawase, et al. Anserine, a Histidine-Containing Dipeptide, Suppresses Pressure Overload-Induced Systolic Dysfunction by Inhibiting Histone Acetyltransferase Activity of p300 in Mice. International Journal of Molecular Sciences. 2024. 25. 4. 2344-2344
Swati Mittal, Maki Komiyama, Yuka Ozaki, Hajime Yamakage, Noriko Satoh-Asahara, Hiromichi Wada, Akihiro Yasoda, Masafumi Funamoto, Yasufumi Katanasaka, Yoichi Sunagawa, et al. Impact of smoking initiation age on nicotine dependency and cardiovascular risk factors: a retrospective cohort study in Japan. European heart journal open. 2024. 4. 1. oead135
Mina Ishioka, Yuma Nihashi, Yoichi Sunagawa, Koji Umezawa, Takeshi Shimosato, Hiroshi Kagami, Tatsuya Morimoto, Tomohide Takaya. Myogenetic Oligodeoxynucleotide Induces Myocardial Differentiation of Murine Pluripotent Stem Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023. 24. 18
Masazumi Iwashita, Ryuta Shioi, Mitsuru Sugiyama, Kohjiro Hashizume, Toshiyuki Kan, Shiomi Naito, Hidemichi Takai, Yuto Kawase, Toshihide Hamabe-Horiike, Yasufumi Katanasaka, et al. Monodemethylated Metabolites of Orally Administered Nobiletin: Identification and Quantitation in Rat Plasma and Tissues. Journal of agricultural and food chemistry. 2023. 71. 26. 10028-10036

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MISC (245)：

清水聡史, 清水聡史, 山田美帆, 片桐宇大, 砂川陽一, 砂川陽一, 砂川陽一, 船本雅文, 船本雅文, 茂木光, et al. 培養心筋細胞を用いたハイスループットスクリーニングによる心不全治療薬の探索. 日本抗加齢医学会総会プログラム・抄録集. 2021. 21st
清水果奈, 清水果奈, 船本雅文, 船本雅文, 砂川陽一, 砂川陽一, 砂川陽一, 刀坂泰史, 刀坂泰史, 刀坂泰史, et al. 抗血小板薬サルポグレラートは圧負荷心不全モデルマウスにおいてERK1/2-GATA4経路を阻害することで心保護作用を示した. 日本抗加齢医学会総会プログラム・抄録集. 2021. 21st
刀坂泰史, 若林弘樹, 宮崎雄輔, 宮崎雄輔, 宮崎雄輔, 砂川陽一, 砂川陽一, 砂川陽一, 船本雅文, 船本雅文, et al. アルギニンメチル化酵素PRMT5の心筋特異的過剰発現は加齢に伴う心肥大および心機能低下を促進する. 日本抗加齢医学会総会プログラム・抄録集. 2021. 21st
砂川陽一, 砂川陽一, 砂川陽一, 高井秀通, 内藤汐美, 船本雅文, 船本雅文, 清水果奈, 清水果奈, 清水聡史, et al. カンキツ由来化合物ノビレチンはp300-HAT活性制御を介して心不全進展を抑制する. 日本抗加齢医学会総会プログラム・抄録集. 2021. 21st
海野瑞紀, 砂川陽一, 砂川陽一, 砂川陽一, 片山歩実, 船本雅文, 船本雅文, 清水果奈, 清水果奈, 清水聡史, et al. 不飽和脂肪酸であるEPA・DHAはp300-HAT阻害を介して心不全の進行を抑制した. 日本栄養・食糧学会大会講演要旨集. 2021. 75th

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Books (4)：

心不全(第2版) 上巻
日本臨牀 2018
機能性表示食品DATA BOOK
日本抗加齢協会メディカルビュー社 2017
日本抗加齢医学会雑誌
日本抗加齢医学会 2015
Functional Food
2015

Education (3)：

2009 - 2012 Kyoto University School of Medicine and Faculty of Medicine Human Health Science
2004 - 2006 Osaka Prefecture University
2000 - 2004 Osaka Prefecture University

Professional career (1)：

人間健康学 (京都大学)

Work history (6)：

2021/10 - 現在 University of Shizuoka Divison of Molecular Medicine, School of Pharmaceutical Sciences
2014/08 - 現在 University of Shizuoka School of Pharmaceutical Sciences Research Assistant
2013/08 - 2014/07 Kyoto Medical Center Department of Translational Research
2012/04 - 2013/07 University of Shizuoka School of Pharmaceutical Sciences Post Doctor
2009/04 - 2012/03 Kyoto University Graduate school of Medicine and Faculty of Medicine, Division of Human Health Sciences

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Awards (7)：

2018/07 - 日本薬学会東海支部平成30年度学術奨励賞食品由来天然化合物を用いた心血管疾患薬物治療に関する研究
2017/05 - 第3回国際心血管薬物療法学会日本部会研究奨励賞心筋細胞肥大の過程におけるGATA4のリン酸化とアセチル化のクロストークについて
2015/05 - The XVIIth International Congress of the International Society of Cardiovascular Pharmacotherapy YIA First Prize Auraptene, a Coumaric Compounds analogous, Prevented Cardiac Hypertrophy by Activating PPARα After Myocardial Infarction in Rats
2014/10 - Young Investigator Award Auraptene, a Coumaric Compounds analogous, Improved the Worsening of Systolic Function by Activating Mitochondrial Function After Myocardial Infarction in Rats
2012/05 - The XVIIth International Congress of the International Society of Cardiovascular Pharmacotherapy YIA First Prize Curcumin, a p300 HAT Inhibitor, Prevents the Development of Hypertension-induced Left Ventricular Hypertrophy in Rats

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Association Membership(s) (7)：

Japan society of Nutrition and Food Science , JAPANESE HEART FAILURE SOCIETY , Anti-Aging Society of Japan , International Congress of the International Society of Cardiovascular Pharmacotherapy, Japan section , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN , The Japanese Circulation Society

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