Research field (3)：
Cell biology
, Clinical pharmacy
, Physiology
Research keywords (3)：
cardiomyocyte
, sarcomere dynamics
, in vivo imaging
Research theme for competitive and other funds (13)：
2022 - 2025 骨格筋機能維持・改善にむけた分子栄養学的基盤研究
2021 - 2024 In vivo ナノ解析による心筋収縮のリズム調節機構の解明
2020 - 2024 Fundamental research on cardiac nanophysiology for clinical application
2018 - 2021 In vivoナノイメージングによる心疾患の病態解析
2018 - 2020 In vivoナノイメージングによる心疾患の病態解析
2018 - 2020 心筋興奮収縮連関のin vivoナノ解析
2015 - 2018 Elucidation of cardiac regulatory mechanisms by in vivo nano-imaging
2014 - 2018 Development of core technologies for heart diagnostic imaging apparatus based on nanoanalysis
2015 - 2017 熱パルスによる心疾患治療デバイスの基盤技術の開発
2011 - 2016 Elucidation of the heart's functions by in vivo nano-imaging
2011 - 2015 Elucidation of cardiac excitation-contraction coupling by in vivo nano-imaging
2011 - 2014 生体内ナノイメージングによる細胞ダイナミクスの解析
2011 - 2013 Development of molecular imaging technologies for the early diagnosis of heart disease
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Papers (33)：
Fuyu Kobirumaki-Shimozawa, Kotaro Oyama, Tomohiro Nakanishi, Shin’ichi Ishiwata, Norio Fukuda. Asynchronous movement of sarcomeres in myocardium under living conditions: role of titin. Frontiers in Physiology. 2024. 15
Yoshitaka Tsuboi, Kotaro Oyama, Fuyu Kobirumaki-Shimozawa, Takashi Murayama, Nagomi Kurebayashi, Toshiaki Tachibana, Yoshinobu Manome, Emi Kikuchi, Satoru Noguchi, Takayoshi Inoue, et al. Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes. Journal of General Physiology. 2022. 154. 11
Tomohiro Nakanishi, Kotaro Oyama, Hiroyuki Tanaka, Fuyu Kobirumaki-Shimozawa, Shuya Ishii, Takako Terui, Shin’ichi Ishiwata, Norio Fukuda. Effects of omecamtiv mecarbil on the contractile properties of skinned porcine left atrial and ventricular muscles. Frontiers in Physiology. 2022. 13
Kotaro Oyama, Vadim Zeeb, Toshiko Yamazawa, Nagomi Kurebayashi, Fuyu Kobirumaki-Shimozawa, Takashi Murayama, Hideto Oyamada, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, et al. Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating. Proceedings of the National Academy of Sciences. 2022. 119. 32
Seiichi Tsukamoto, Kotaro Oyama, Teruyuki Fujii, Fuyu Kobirumaki-Shimozawa, Togo Shimozawa, Seine A. Shintani, Shin'ichi Ishiwata, Norio Fukuda. Simultaneous High-Precision Imaging of Local Calcium and Single Sarcomere Length in Rat Neonatal Cardiomyocytes via Expression of Yellow Cameleon-Nano140 in Z-Discs. BIOPHYSICAL JOURNAL. 2016. 110. 3. 367A-367A
Fuyu Kobirumaki-Shimozawa, Kotaro Oyama, Togo Shimozawa, Takashi Ohki, Takako Terui, Shin'ichi Ishiwata, Norio Fukuda. High-Speed, High-Performance Real-Time Imaging of Physiological Sarcomere Dynamics in the Beating Mouse Heart in Vivo. BIOPHYSICAL JOURNAL. 2016. 110. 3. 463A-463A
