Fuyu Kobirumaki-Shimozawa

コビルマキフユ | Fuyu Kobirumaki-Shimozawa

Affiliation and department：
Job title：助教

Research field (3)： Cell biology , Clinical pharmacy , Physiology

Research keywords (3)： cardiomyocyte , sarcomere dynamics , in vivo imaging

Research theme for competitive and other funds (13)：

2022 - 2025 骨格筋機能維持・改善にむけた分子栄養学的基盤研究
2021 - 2024 In vivo ナノ解析による心筋収縮のリズム調節機構の解明
2020 - 2024 Fundamental research on cardiac nanophysiology for clinical application
2018 - 2021 In vivoナノイメージングによる心疾患の病態解析
2018 - 2020 In vivoナノイメージングによる心疾患の病態解析

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Papers (33)：

Fuyu Kobirumaki-Shimozawa, Kotaro Oyama, Tomohiro Nakanishi, Shin’ichi Ishiwata, Norio Fukuda. Asynchronous movement of sarcomeres in myocardium under living conditions: role of titin. Frontiers in Physiology. 2024. 15
Shuya Ishii, Kotaro Oyama, Fuyu Kobirumaki-Shimozawa, Tomohiro Nakanishi, Naoya Nakahara, Madoka Suzuki, Shin’ichi Ishiwata, Norio Fukuda. Myosin and tropomyosin-troponin complementarily regulate thermal activation of muscles. Journal of General Physiology. 2023. 155. 12
Yoshitaka Tsuboi, Kotaro Oyama, Fuyu Kobirumaki-Shimozawa, Takashi Murayama, Nagomi Kurebayashi, Toshiaki Tachibana, Yoshinobu Manome, Emi Kikuchi, Satoru Noguchi, Takayoshi Inoue, et al. Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes. Journal of General Physiology. 2022. 154. 11
Tomohiro Nakanishi, Kotaro Oyama, Hiroyuki Tanaka, Fuyu Kobirumaki-Shimozawa, Shuya Ishii, Takako Terui, Shin’ichi Ishiwata, Norio Fukuda. Effects of omecamtiv mecarbil on the contractile properties of skinned porcine left atrial and ventricular muscles. Frontiers in Physiology. 2022. 13
Kotaro Oyama, Vadim Zeeb, Toshiko Yamazawa, Nagomi Kurebayashi, Fuyu Kobirumaki-Shimozawa, Takashi Murayama, Hideto Oyamada, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, et al. Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating. Proceedings of the National Academy of Sciences. 2022. 119. 32

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MISC (12)：

大山廣太郎, 大山廣太郎, 新谷正嶺, 小比類巻生, 塚本精一, 下澤東吾, 鈴木団, 鈴木団, 石渡信一, 福田紀男. サルコメア収縮を視て操作する光技術. 日本筋学会学術集会プログラム・抄録集. 2018. 4th
Seiichi Tsukamoto, Kotaro Oyama, Teruyuki Fujii, Fuyu Kobirumaki-Shimozawa, Togo Shimozawa, Seine A. Shintani, Shin'ichi Ishiwata, Norio Fukuda. Simultaneous High-Precision Imaging of Local Calcium and Single Sarcomere Length in Rat Neonatal Cardiomyocytes via Expression of Yellow Cameleon-Nano140 in Z-Discs. BIOPHYSICAL JOURNAL. 2016. 110. 3. 367A-367A
Fuyu Kobirumaki-Shimozawa, Kotaro Oyama, Togo Shimozawa, Takashi Ohki, Takako Terui, Shin'ichi Ishiwata, Norio Fukuda. High-Speed, High-Performance Real-Time Imaging of Physiological Sarcomere Dynamics in the Beating Mouse Heart in Vivo. BIOPHYSICAL JOURNAL. 2016. 110. 3. 463A-463A
LU Ping, SHIMURA Daisuke, JIAO Qibin, UESUGI Ken, KAJIMURA Ryosuke, KOBIRUMAKI Fuyu, AKAIKE Toru, KUSAKARI Yoichiro. Venous identity lost in jugular segment of carotid-jugular (C-J) shunt but arterial identity strengthened in pulmonary artery in adult rats with C-J shunt. Journal of Physiological Sciences. 2014. 64. Supplement 1
Fuyu Kobirumaki-Shimozawa, Kotaro Oyama, Akari Mizuno, Takako Terui, Togo Shimozawa, Takashi Ohki, Shin'ichi Ishiwata, Norio Fukuda. Real-Time Imaging of Sarcomere Dynamics in the Mouse Heart In Vivo. BIOPHYSICAL JOURNAL. 2014. 106. 2. 645A-646A

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Lectures and oral presentations (21)：

Synchrony of sarcomere dynamics in the in vivo beating mouse heart.
(2023)
In vivo cardiac nano-physiology: sarcomere synchronization and ventricular contractility
(2022)
Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart.
(2021)
Analysis of cardiac sarcomere dynamics by in vivo nano-imaging.
(2020)
Nano-imaging of individual sarcomere dynamics in the beating mouse heart in vivo.
(2018)

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Education (3)：

Work history (4)：

- 現在 The Jikei University School of Medicine Department of Cell Physiology Research Associate
2009/04 - 2010/03 The University of Tokyo Department of Physics, School of Science Ppostdoctoral fellow
2007/04 - 2009/03 Tokyo Medical University
2004/04 - 2007/03 The University of Tokyo

Awards (2)：

2016 - The Physiological Society of Japan Irisawa HiroshiAya Memorial Young Researcher Award
2014 - Japan Heart Foundation Japan Heart Foundation Hiroshi Irisawa Aya Memorial Research Honors

Association Membership(s) (3)：

Society of Nano Science and Technology , THE BIOPHYSICAL SOCIETY OF JAPAN , THE PHYSIOLOGICAL SOCIETY OF JAPAN

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