Rchr
J-GLOBAL ID：201801019061434713
Update date: Nov. 21, 2024
Higa Tsunaki
Higa Tsunaki
Affiliation and department：
Research field (1)：
Developmental biology
Research theme for competitive and other funds (3)：
- 2023 - 2025 p57系統追跡と1細胞解析を用いた条件誘導型幹細胞の網羅的探索と脱分化機構の解明
- 2018 - 2021 Deciphering positive and negative selection in thymocyte from information theoretic approach
- 2019 - 2021 Exploration of cancer stem cells using a marker gene p57 and establishment of an eradicative anti-cancer therapy
Papers (11)：
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Daisuke Koga, Shogo Nakayama, Tsunaki Higa, Keiichi I Nakayama. Identification and characterization of an enhancer element regulating expression of Cdkn1c (p57 gene). Genes to cells. 2024
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Tsunaki Higa, Keiichi I Nakayama. Cell cycle heterogeneity and plasticity of colorectal cancer stem cells. Cancer science. 2024
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Takeru Oka, Tsunaki Higa, Osamu Sugahara, Daisuke Koga, Shogo Nakayama, Keiichi I Nakayama. Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence After Chemotherapy of Intestinal Tumors. Cancer research. 2023
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Tsunaki Higa, Yasutaka Okita, Akinobu Matsumoto, Shogo Nakayama, Takeru Oka, Osamu Sugahara, Daisuke Koga, Shoichiro Takeishi, Hirokazu Nakatsumi, Naoki Hosen, et al. Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium. Nature communications. 2022. 13. 1. 1500-1500
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Hirokazu Nakatsumi, Takeru Oka, Tsunaki Higa, Michiko Shirane, Keiichi I Nakayama. Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1. Genes to cells : devoted to molecular & cellular mechanisms. 2018. 23. 7. 599-605
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MISC (7)：
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Akimasa Hoshi, Takahiro Horinouchi, Takuya Harada, Tsunaki Higa, Tsunehito Higashi, Koji Terada, Yosuke Mai, Prabha Nepal, Mika Horiguchi, Chizuru Hatate, et al. Cell signaling mechanism activated by endothelin-1 in rat skeletal muscle cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 93P-93P
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Takahiro Horinouchi, Tsunehito Higashi, Koji Terada, Tsunaki Higa, Yosuke Mai, Chizuru Hatate, Prabha Nepal, Mika Horiguchi, Takuya Harada, Soichi Miwa. Identification and characterization of STIM1L, a novel splice variant of STIM1. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 91P-91P
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Takahiro Horinouchi, Tsunaki Higa, Hiroyuki Aoyagi, Koji Terada, Tadashi Nishiya, Soichi Miwa. Negative regulation of endothelin type A receptor-operated TRPC6 by PKA phosphorylation. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 211P-211P
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Tsunaki Higa, Takahiro Horinouchi, Hiroyuki Aoyagi, Koji Terada, Tadashi Nishiya, Soichi Miwa. Regulatory mechanism of endothelin type A receptor-operated Ca2+ entry via TRPC3 and TRPC6 channels. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 211P-211P
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Takahiro Horinouchi, Tsunaki Higa, Tadashi Nishiya, Hiroyuki Aoyagi, Hiroyuki Suzuki, Arata Nishimoto, Soichi Miwa. Negative regulation of endothelin type A receptor-operated TRPC6 by adenylate cyclase/cAMP/PKA pathway. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2011. 115. 112P-112P
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Lectures and oral presentations (6)：
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Tracing intestinal p57 + cells uncovers spatiotemporal reprogramming of regenerating epithelium and the identity of cancer stem cells
(The 41st Sapporo International Cancer Symposium 2023)
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p57 陽性幹細胞は腸管上皮の再生と腫瘍の基盤となる
(日本細胞生物学会第75 回大会 2023)
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Tracing intestinal p57+ cells uncovers spatiotemporal reprogramming of regenerating epithelium and the identity of cancer stem cells.
(2023)
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p57 陽性タフト細胞は胃底腺幹細胞として機能する
(第45 回日本分子生物学会年会 2022)
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Tracing p57+ cells uncovers spatiotemporal reprogramming of differentiated cells underlying regeneration and neoplasia in the intestinal epithelium
(2021)
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