Rchr
J-GLOBAL ID:201801019371273809
Update date: Jan. 30, 2024
Onishi Nobuyuki
オオニシ ノブユキ | Onishi Nobuyuki
Affiliation and department:
Other affiliations (1):
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Keio University
School of Medicine Department of Plastic and Reconstructive Surgery
Research field (3):
Molecular biology
, Laboratory animal science
, Tumor biology
Research theme for competitive and other funds (5):
- 2019 - 2022 Development of easy-to-use genome editing protein synthesis system and one-step genetically modified animal production method
- 2016 - 2019 Development of novel mouse brain tumor model using in vivo electroporation and piggyBac system
- 2013 - 2015 Development of recurrence mouse brain tumor model using inducible iCSCs and identification of target molecules in recurrence tumor
- 2010 - 2011 Establishment of human induced cancer stem cells(iCSCs) and malignant brain tumor models derived from neural stem cells
- 2005 - 2007 DNA損傷応答におけるWip1による細胞周期チェックポイントの解除機構
Papers (61):
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Ryotaro Ohkuma, Sakiko Miura, Satoshi Muto, Yoshitaka Toyomasu, Yuki Fujimoto, Katsuaki Ieguchi, Nobuyuki Onishi, Takashi Shimizu, Makoto Watanabe, Daisuke Takayanagi, et al. Novel quantitative immunohistochemical analysis for evaluating PD-L1 expression with phosphor-integrated dots for predicting the efficacy of patients with cancer treated with immune checkpoint inhibitors. Frontiers in immunology. 2023. 18. 14. 1260492-1260492
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Ryotaro Ohkuma, Yuki Fujimoto, Katsuaki Ieguchi, Nobuyuki Onishi, Makoto Watanabe, Daisuke Takayanagi, Tsubasa Goshima, Atsushi Horiike, Kazuyuki Hamada, Hirotsugu Ariizumi, Yuya Hirasawa, Tomoyuki Ishiguro, Risako Suzuki, Nana Iriguchi, Toshiaki Tsurui, Yosuke Sasaki, Mayumi Homma, Toshiko Yamochi, Kiyoshi Yoshimura, Mayumi Tsuji, Yuji Kiuchi, Shinichi Kobayashi, Takuya Tsunoda, Satoshi Wada. Monocyte subsets associated with the efficacy of anti-PD-1 antibody monotherapy. Oncol Lett. 2023. 26. 3. 381-381
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信末 博行, 清水 孝恒, 高橋 信博, 山口 さやか, 杉原 英志, 大西 伸幸, 佐谷 秀行. MKL1の阻害は化学療法抵抗性骨肉腫細胞において抗がん剤の抗腫瘍効果を増強する(Inhibition of MKL1 enhances the effects of anticancer drugs in chemoresistant osteosarcoma cells). 日本癌学会総会記事. 2022. 81回. J-1026
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Kazuhide Miyamoto, Hodaka Hayabuchi, Yukiko Tokifuji, Makoto Ando, Nobuyuki Onishi, Tadashi Okamuara, Akihiko Yoshimura, Shunsuke Chikuma. A Protein Kinase D Inhibitor Suppresses AKT on T cells and Antagonizes Cancer Immunotherapy by Anti-PD-1. International immunology. 2022. 34. 12. 609-619
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Megumi Uetaki, Nobuyuki Onishi, Yoshinao Oki, Takatsune Shimizu, Eiji Sugihara, Oltea Sampetrean, Takashi Watanabe, Hisano Yanagi, Kiyoshi Suda, Hiroya Fujii, et al. Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis. Molecular biology of the cell. 2022. 33. 9. mbcE21120609
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MISC (32):
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齋藤潤, 齋藤潤, 大西伸幸, 杉原英志, 清水孝恒, 清水孝恒, 木村聖美, 小池直義, 小池直義, サンペトラ オルテア, et al. Benzaldehydeは癌細胞のAxl受容体の発現を14-3-3ζを介して抑制し,Osimertinibによる治療抵抗性を制する. 日本癌学会学術総会抄録集(Web). 2021. 80th
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信末博行, 清水孝恒, 高橋信博, 山口さやか, 杉原英志, 大西伸幸, 佐谷秀行. 治療抵抗性の骨肉腫幹細胞を標的としたアクチン細胞骨格動態に基づく治療戦略. 日本癌学会学術総会抄録集(Web). 2021. 80th
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齋藤潤, 齋藤潤, 大西伸幸, 杉原英志, 清水孝恒, 清水孝恒, 木村聖美, 小池直義, 小池直義, サンペトラ オルテア, et al. Benzaldehyde activates AMPK via cancer specific upregulated 14-3-3ζ. 日本癌学会学術総会抄録集(Web). 2019. 78th
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大西伸幸, 大塚正人, 佐藤正宏, 佐谷秀行. In vivoエレクトロポレーションを用いたマウス発がんモデルならびに簡便な遺伝子改変マウス作製法の開発. がんと代謝研究会プログラム&抄録集. 2018. 6th. 97
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Kofuji Satoshi, Akiyoshi Hirayama, Naoya Sakamoto, Kazutaka Sumita, Hirofumi Yoshino, Mikako Warren, Risa Kawaguchi, Tatsuya Ozawa, Nobuyuki Onishi, Kara Wolfe, et al. GTP METABOLIC SWITCH LEADS TO NUCLEOLAR TRANSFORMATION AND MALIGNANT GROWTH OF GLIOBLASTOMA. NEURO-ONCOLOGY. 2017. 19. 35-35
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Education (2):
- 2002 - 2008 Kobe University
- 1998 - 2002 Kindai University Faculty of Science and Engineering
Professional career (1):
Work history (9):
- 2022/10 - 現在 Keio University School of Medicine Department of Plastic and Reconstructive Surgery
- 2022/05 - 現在 Showa University Dept. of Clin. Diag Oncol., Clin. Res. Inst. for Clin. Pharmacol. and Ther.
- 2022/05 - 2022/09 Keio University School of Medicine Department of Plastic and Reconstructive Surgery
- 2022/04 - 2022/04 Keio University School of Medicine Department of Plastic and Reconstructive Surgery
- 2017/04 - 2022/03 株式会社 島津製作所 基盤技術研究所 嘱託研究員
- 2017/04 - 2022/03 Keio University School of Medicine Institute for Advanced Medical Research (Division of Gene Regulation)
- 2008/10 - 2017/03 Keio University School of Medicine Institute for Advanced Medical Research (Division of Gene Regulation)
- 2008/04 - 2008/09 Kobe University
- 2005/04 - 2008/03 Kobe University
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