Iwasaki Hiroki

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (1)：薬学教育

Research theme for competitive and other funds (3)：

2016 - 2023 新規抗がん剤の創製を指向したアセトゲニン誘導体のTHF環部分の構造活性相関研究
2013 - 2017 Structure activity relationships study of dual-core type acetogenin analogues for development of novel antitumor agents
2010 - 2013 Development of novel synthetic reactions based on release of strain energy in small ring system and its application to total syntheses of natural products

Papers (43)：

Kota Yoshioka, Hiroki Iwasaki, Mako Hanaki, Saho Ito, Yuzuha Iwamoto, Rio Ichihara, Hisanori Nambu. A SmI<sub>2</sub>-mediated reductive cyclisation reaction using the trifluoroacetamide group as the radical precursor. Organic & Biomolecular Chemistry. 2024. 22. 10. 1988-1992
Hiroki Iwasaki, Mari Ikemoto, Haruka Shibata, Yuka Shima, Erina Himeno, Naoto Kojima, Masayuki Yamashita, Hisanori Nambu. Regioselective SmI2-Mediated Radical ipso-Substitution Cyclization for the Construction of Pyrrolophenanthridinone Skeletons: The Synthesis of Amaryllidaceae Alkaloids. Chemical and Pharmaceutical Bulletin. 2023. 71. 7. 515-519
Takuya Matsumoto, Saya Okazaki, Shui Aoki, Aya Niki, Hiroki Iwasaki, Minoru Ozeki, Masayuki Yamashita, Naoto Kojima, Ikuo Kawasaki. Facile Synthesis of 5-Alkoxy-4-Aryltetrahydrofuran-2-one Using Hypervalent Iodine Reagents. Tetrahedron Letters. 2023. 118. 154382-154382
Hiroyuki Hosomi, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Hisanori Nambu, Naoto Kojima. Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines. Chemical and Pharmaceutical Bulletin. 2022. 70. 11. 823-826
Kaito Ohta, Tetsuya Fushimi, Mutsumi Okamura, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita, Naoto Kojima. Structure-antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety. RSC Advances. 2022. 12. 25. 15728-15739

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Lectures and oral presentations (70)：

ケトヘキソース類のピラノース型糖供与体の合成とそのグリコシル化反応における比較
(第50回反応と合成の進歩シンポジウム 2024)
N-アシルスピナセアミン誘導体で発生する配座異性体の解明
(第74回日本薬学会関西支部総会・大会 2024)
ヨウ化サマリウムを用いたアミノケチルラジカルと多重結合の閉環反応の開発-ヨウ化サマリウムによるアミドの還元的環化反応-
(第74回日本薬学会関西支部総会・大会 2024)
イソキノリンN-オキシドを中間体とした1-アミノイソキノリン誘導体のone-pot合成反応
(第44回有機合成若手セミナー 2024)
スルホニウム塩を用いる活性メチレン化合物のシクロプロパン構築法
(日本薬学会第144年会 2024)

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