Rchr
J-GLOBAL ID:201801019426952484
Update date: Apr. 08, 2024
Hajime Mizuno
ミズノ ハジメ | Hajime Mizuno
Affiliation and department:
Job title:
Professor
Research field (1):
Pharmaceuticals - analytical and physicochemistry
Research keywords (2):
質量分析
, 分析化学
Research theme for competitive and other funds (10):
- 2022 - 2025 Development of sensitive intracellular molecular analytical method by single-cell organelle injection and derivatization
- 2022 - 2025 Development of biomimetic nano-antibody that neutralizes target molecules in blood for cancer therapy
- 2019 - 2022 Development of mitochondrial mass spectrometry in live single-cell.
- 2016 - 2019 Subcellular molecular localization analysis by in situ derivatization
- 2012 - 2016 Development of low polar molecules-targetted Live single-cell MS by piezo-oscillated nano-CI.
- 2009 - 2011 Development of Molecular Species-Specific Live-Single Cell MS with Affinity-modified Nanospray Tips.
- 2008 - 2011 Single-cell on-time molecular analysis by hyper-sensitive video-mass scope
- 2008 - 2009 Development of single-cell nano mass spectrometry by targeted molecular trapping
- 2007 - 2008 Development of on-time cellular protein analysis method using nanospray tips filled with silica-monolyth
- 2006 - 2007 Development of Dual-Tandem-Mass Spectrometer with a New Ion-trap and Its Application to Analysis of Molecular Nano-dynamics of a Cell
Show all
Papers (61):
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Jo Sakata, Aogu Furusho, Eiji Sugiyama, Iwao Sakane, Kenichiro Todoroki, Hajime Mizuno. Development of a highly efficient solubilization method for mass spectrometric analysis of phospholipids in living single cells. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2024
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Kenichiro Todoroki, Nan Fukudo, Yuto Kudoh, Hajime Mizuno, Jun Zhe Min, Shimako Tanaka, Shinya Uchida, Noriyuki Namiki, Toshimasa Toyo'oka. Development of an on-site therapeutic drug monitoring method using a portable spectrometer. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2024
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Kenichiro Todoroki, Daichi Hamada, Tomohiro Yamada, Taro Saito, Yutaka Shimizu, Eiji Sugiyama, Hajime Mizuno, Hideki Hayashi, Kaori Tsukakoshi, Kazunori Ikebukuro. Development of a liquid chromatography-based versatile bioanalysis for bevacizumab based on pretreatment combining aptamer affinity purification and centrifugal ultrafiltration concentration. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2023
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Eiji Sugiyama, Yuki Nishiya, Kenji Yamashita, Ryo Hirokawa, Yoshiteru Iinuma, Takashi Nirasawa, Hajime Mizuno, Yoshitaka Hamashima, Kenichiro Todoroki. Charged chiral derivatization for enantioselective imaging of D-,L-2-hydroxyglutaric acid using ion mobility spectrometry/mass spectrometry. Chemical communications (Cambridge, England). 2023
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Tomonobu Uchino, Daichi Kamiya, Hiroaki Yagi, Hiyori Fujino-Shimaya, Ichiro Hatta, Shun Fujimori, Yasunori Miyazaki, Yukako Kirishita, Yuko Sano, Hajime Mizuno, et al. Comparative analysis of intercellular lipid organization and composition between psoriatic and healthy stratum corneum. Chemistry and physics of lipids. 2023. 254. 105305-105305
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MISC (48):
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杉山 栄二, 水野 初, 轟木 堅一郎. 医化学研究における質量分析の応用~イメージングから血液マーカー開発まで~ ジアステレオマー誘導体化によるキラル分子のエナンチオ選択的イメージング. JSBMS Letters. 2022. 47. Suppl. 48-48
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阪田 晟, 水野 初, 古庄 仰, 杉山 栄二, 轟木 堅一郎. 1細胞質量分析によるがん特異的代謝物の探索. JSBMS Letters. 2022. 47. Suppl. 91-91
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小林 直央, 北條 泰成, 後藤 厚子, 杉山 栄二, 水野 初, 驫木 堅一郎. 3種抗体医薬に対する高親和性DNAアプタマーの効率的な探索とその評価. 日本薬学会年会要旨集. 2022. 142年会. 26H-pm17S
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竹内 大揮, 阪田 晟, 加藤 良浩, 水野 初, 工藤 忍, 坂根 巌, 杉山 栄二, 轟木 堅一朗. 1細胞質量分析による細胞内リン脂質分析法の開発. 日本薬学会年会要旨集. 2022. 142年会. 27PO3-11S
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山口 侑季乃, 西島 公佳, 水野 初, 唐川 幸聖, 原田 真志, 杉山 栄二, 中山 聡, 轟木 堅一郎. 誘導体化による一細胞内アミノ酸の高感度質量分析法の開発. 日本薬学会年会要旨集. 2022. 142年会. 27PO3-12S
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Education (2):
- - 2007 Hiroshima University Graduate School of Science Department of Mathematical and Life Sciences
- - 2003 Hiroshima University Faculty of Science Department of Chemistry
Professional career (1):
Work history (6):
Awards (1):
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