Hajime Mizuno

ミズノハジメ | Hajime Mizuno

Affiliation and department：
Job title： Professor

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research keywords (2)：質量分析 , 分析化学

Research theme for competitive and other funds (11)：

2022 - 2025 Development of biomimetic nano-antibody that neutralizes target molecules in blood for cancer therapy
2022 - 2025 Development of sensitive intracellular molecular analytical method by single-cell organelle injection and derivatization
2022 - 2025 Development of biomimetic nano-antibody that neutralizes target molecules in blood for cancer therapy
2019 - 2022 Development of mitochondrial mass spectrometry in live single-cell.
2016 - 2019 Subcellular molecular localization analysis by in situ derivatization

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Papers (78)：

Aogu Furusho, Daiki Takeuchi, Jo Sakata, Takuma Yanagisawa, Hajime Mizuno, Yuta Terui, Masafumi Iharada, Hironori Takai, Eiji Sugiyama, Iwao Sakane, et al. Mass spectrometric analysis of the amiodarone-induced alteration of phosphatidylcholines in living single cells. Journal of pharmaceutical and biomedical analysis. 2025. 265. 117045-117045
Takuma YANAGISAWA, Takahiro TAKAYAMA, Eiji SUGIYAMA, Hajime MIZUNO, Toshimasa TOYO’OKA, Kenichiro TODOROKI. Development of a Highly Sensitive Analytical Method of d and l-Amino Acids Constructed by Multiple Regression Prediction and Novel Chiral Derivatization Reagents for UHPLC-ESI-MS/MS Analysis. CHROMATOGRAPHY. 2025. 46. 3. 135-144
Tomohiro Yamada, Aogu Furusho, Kenji Kojima, Eiji Sugiyama, Hajime Mizuno, Kaori Tsukakoshi, Hideki Hayashi, Takeshi Yamano, Takashi Hasebe, Toshimasa Toyo'oka, et al. Development of a mertansine-specific DNA aptamer and novel high-throughput sandwich enzyme-linked oligonucleotide assay for quantification and characterization of trastuzumab emtansine. Biosensors & bioelectronics. 2025. 272. 117108-117108
Yuko Terada, Takumi Hisada, Masaya Fujitani, Ryoka Nakayama, Serina Fukui, Kei Kanie, Ryuji Kato, Takashi Shigeta, Eiji Sugiyama, Hajime Mizuno, et al. (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidine-2-carboxylate derivatization combined with UPLC/ESI-MS/MS as a powerful method for dipeptide determination in foods: an application example in fermented cocoa beans. Journal of Food Composition and Analysis. 2024. 106759-106759
Tomohiro Yamada, Kaori Tsukakoshi, Aogu Furusho, Eiji Sugiyama, Hajime Mizuno, Hideki Hayashi, Takeshi Yamano, Hideki Kumobayashi, Takashi Hasebe, Kazunori Ikebukuro, et al. Simple and fast one-step FRET assay of therapeutic mAb bevacizumab using anti-idiotype DNA aptamer for process analytical technology. Talanta. 2024. 277. 126349-126349

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MISC (51)：

濱田大地, 齋藤太郎, 清水裕, 杉山栄二, 塚越かおり, 水野初, 豊岡利正, 池袋一典, 轟木堅一郎. 抗イディオタイプDNAアプタマー固定化セファロースを用いる抗体医薬のアフィニティー精製-LC分析法の開発. 分析化学討論会講演要旨集(Web). 2023. 83rd
杉山栄二, 水野初, 轟木堅一郎. 医化学研究における質量分析の応用~イメージングから血液マーカー開発まで~ ジアステレオマー誘導体化によるキラル分子のエナンチオ選択的イメージング. JSBMS Letters. 2022. 47. Suppl. 48-48
阪田晟, 水野初, 古庄仰, 杉山栄二, 轟木堅一郎. 1細胞質量分析によるがん特異的代謝物の探索. JSBMS Letters. 2022. 47. Suppl. 91-91
小林直央, 北條泰成, 後藤厚子, 杉山栄二, 水野初, 驫木堅一郎. 3種抗体医薬に対する高親和性DNAアプタマーの効率的な探索とその評価. 日本薬学会年会要旨集. 2022. 142年会. 26H-pm17S
竹内大揮, 阪田晟, 加藤良浩, 水野初, 工藤忍, 坂根巌, 杉山栄二, 轟木堅一朗. 1細胞質量分析による細胞内リン脂質分析法の開発. 日本薬学会年会要旨集. 2022. 142年会. 27PO3-11S

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Education (2)：

- 2007 Hiroshima University Graduate School of Science Department of Mathematical and Life Sciences
- 2003 Hiroshima University Faculty of Science Department of Chemistry

Professional career (1)：

博士(理学) (広島大学)

Work history (6)：

2022/04 - 現在 Meijo University Faculty of Pharmacy Professor
2020/04 - 2022/03 University of Shizuoka School of Pharmaceutical Sciences
2017/09 - 2020/03 University of Shizuoka School of Pharmaceutical Sciences
2015/04 - 2017/08 University of Shizuoka School of Pharmaceutical Sciences
2013/04 - 2015/03 理化学研究所生命システム研究センター研究員

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Awards (1)：

2013/09 - 日本分析化学会奨励賞

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