Hayashi Shusaku

ハヤシシュウサク | Hayashi Shusaku

Affiliation and department：
Job title： Associate Professor

Research field (1)： Pharmacology

Research keywords (5)：腸管上皮細胞 , Macrophage , Intestinal Mucosal Barrier , Mucosal Immunology , Inflammatory Bowel Disease

Research theme for competitive and other funds (8)：

2021 - 2024 Creation of New Therapeutic Strategy for Inflammatory Bowel Disease Aiming to Prevent Relapse Based on Rebuilding Mucosal Barrier
2018 - 2021 Development of Novel Therapeutic Medicines for Inflammatory Bowel Disease with Enhancement of IL-10 Production in Intestinal Macrophages
2018 - 2021 A Research of Epithelium-Immune Interaction during Mucosal Repair in Inflammatory Bowel Disease
2016 - 2019 Mode-of-action analysis of Kampo formulae and prediction of their new indications for a wide range of diseases
2015 - 2018 Role of CD206 Positive Macrophages in the Intestinal Homeostasis and Inflammatory Bowel Disease

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Papers (49)：

Takeshi YAMAMOTO, Yosuke KATSUKI, Yuya KANAUCHI, Shusaku HAYASHI, Makoto KADOWAKI. Allergic inflammation disrupts epithelial electrogenic electrolyte transport through cholinergic regulation in the mouse colon. Biomedical Research. 2023. 44. 1. 31-40
Shusaku Hayashi, Chithra K. Muraleedharan, Makito Oku, Sunil Tomar, Simon P. Hogan, Miguel Quiros, Charles A. Parkos, Asma Nusrat. Intestinal epithelial BLT1 promotes mucosal repair. JCI Insight. 2022. 7. 23
Yuya Kanauchi, Takeshi Yamamoto, Minako Yoshida, Yue Zhang, Jaemin Lee, Shusaku Hayashi, Makoto Kadowaki. Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells. Scientific Reports. 2022. 12. 1
Makoto Kadowaki, Takeshi Yamamoto, Shusaku Hayashi. Neuro-immune crosstalk and food allergy: Focus on enteric neurons and mucosal mast cells. Allergology International. 2022. 71. 3. 278-287
Yue Zhang, Takeshi Yamamoto, Shusaku Hayashi, Makoto Kadowaki. Suppression of plasmacytoid dendritic cell migration to colonic isolated lymphoid follicles abrogates the development of colitis. Biomedicine & Pharmacotherapy. 2021. 141. 111881-111881

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MISC (36)：

Nonoka Wakabayashi, Shusaku Hayashi, Makoto Kadowaki. Search for an enhancer of IL-10 production in the intestinal macrophages for new therapy against inflammatory bowel disease. CYTOKINE. 2017. 100. 157-157
Shusaku Hayashi, Mizuki Sendo, Ai Hertati, Kazuyuki Tobe, Makoto Kadowaki. CD206 positive intestinal macrophages contribute to the colonic epithelial wound healing. CYTOKINE. 2017. 100. 128-128
Shusaku Hayashi, Takayuki Hamada, Kana Itoi, Makoto Kadowaki. PI3 Kinase p85 alpha Subunit-Deficient Macrophages Suppress the Development of DSS-Induced Acute Colitis Due to the Enhancement of IL-10 Production. GASTROENTEROLOGY. 2016. 150. 4. S964-S964
Shusaku Hayashi, Takayuki Hamada, Yoko Ishii, Masakiyo Sasahara, Makoto Kadowaki. Nicotine Suppresses Colonic Tumorigenesis Associated With Chronic Colitis Through the Inhibition of IL-6/STAT3 Pathway in Mice. GASTROENTEROLOGY. 2014. 146. 5. S631-S631
Takayuki Hamada, Shusaku Hayashi, Makoto Kadowaki. Pathogenic Role of PI3K P85 alpha Subunit in a Murine Colitis Model Through the Regulation of Intestinal Macrophage Functions. GASTROENTEROLOGY. 2014. 146. 5. S646-S646

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Lectures and oral presentations (4)：

大腸炎マウスの腸管神経系における神経新生の解析
(第97回日本薬理学会年会 2023)
Comprehensive mathematical understanding of the complex control system between organs, and challenge for ultra-early precision medicine.
(Japan-U.S. Research Collaboration Week: Tracking our health trajectories 2023)
Preferential neurogenesis of nitrergic neurons in the myenteric plexus of DSS colitis mouse colon causes the colonic dysmotility in the colitis.
(Digestive Disease Week 2023 2023)
Berberine, a fatty acid synthase activator, enhances IL-10 production in macrophages and suppresses relapse in murine colitis model.
(Digestive Disease Week 2023 2023)

Education (3)：

2006 - 2009 Kyoto Pharmaceutical University Graduate School of Pharmaceutical Sciences
2004 - 2006 Kyoto Pharmaceutical University Graduate School of Pharmaceutical Sciences
2000 - 2004 Kyoto Pharmaceutical University

Professional career (1)：

Work history (3)：

2023/10 - 現在 Kyoto Pharmaceutical University Laboratory of Pharmacology and Experimental Therapeutics Associate Professor
2010/06 - 2023/09 University of Toyama Institute of Natural Medicine Assistant Professor
2019/01 - 2021/10 University of Michigan Department of Pathology Post-Doctoral Fellow

Awards (2)：

2018 - The Pharmaceutical Society of Japan Hokuriku Branch Young Researcher's Award
2016 - 日本薬学会薬理系薬学部会優秀発表賞(生体機能と創薬シンポジウム)

Association Membership(s) (3)：

日本薬学会 , 日本消化器免疫学会 , 日本薬理学会

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