Akiyama Yoshimitsu

アキヤマヨシミツ | Akiyama Yoshimitsu

Research field (1)： Tumor biology

Research keywords (4)： Hereditary cancer , DNA mismatch repair , Epigenetics , Gastrointestinal cancer

Research theme for competitive and other funds (21)：

2020 - 2023 Envolvement of abnormal of SETDB-related histone modification enzyme and tumor immune environment in gastrointestinal cancer
2020 - 2022 Application of multiplex genome editing technology to the development of CAR-T therapy for refractory cancer subtypes
2019 - 2022 Clarification of diversity mechanisms for innovation of refractory cancer treatment
2018 - 2020 Innovation of genome editing technology as the basis to develop molecular subtype panels of intractable cancer
2016 - 2020 Molecular pathology of SET-related histone methyltransferase in refractory cancer

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Papers (107)：

Megumi Hatano, Yoshimitsu Akiyama, Shu Shimada, Kohei Yagi, Keiichi Akahoshi, Michiko Itoh, Minoru Tanabe, Yoshihiro Ogawa, Shinji Tanaka. Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC. Hepatology communications. 2023. 7. 10
Ayano Kabashima, Yuki Matsuo, Saki Ito, Yoshimitsu Akiyama, Takeshi Ishii, Shu Shimada, Atsushi Masamune, Minoru Tanabe, Shinji Tanaka. cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer. Scientific reports. 2022. 12. 1. 10466-10466
Masafumi Akasu, Shu Shimada, Ayano Kabashima, Yoshimitsu Akiyama, Masahiro Shimokawa, Keiichi Akahoshi, Atsushi Kudo, Shoji Yamaoka, Minoru Tanabe, Shinji Tanaka. Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma. Scientific reports. 2021. 11. 1. 16732-16732
田中真二, 島田周, 秋山好光, 新部彩乃, 波多野恵, 下川雅弘, 田邉稔, 小川佳宏. 肝臓の慢性炎症(ウィルス性と栄養性)と肝がんの発症肝臓外科からみた代謝関連肝癌の分子機序と治療戦略. 糖尿病. 2021. 64. Suppl.1. LD-3
Ayano Kabashima, Shu Shimada, Masahiro Shimokawa, Yoshimitsu Akiyama, Minoru Tanabe, Shinji Tanaka. Molecular and immunological paradigms of hepatocellular carcinoma: Special reference to therapeutic approaches. Journal of hepato-biliary-pancreatic sciences. 2021. 28. 1. 62-75

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MISC (7)：

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Awards (2)：

2005/09 - The Japanese Cancer Association The Young Investigator Awards of the Japanese Cancer Association
2000/04 - American Association for Cancer Research-ITO-EN Young Investigator Award APC and β-catenin gene mutations in colorectal adenomas from HNPCC patients.

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