Arai Satoko

新井郷子 | Arai Satoko

Affiliation and department：
Job title： Vice Director
Homepage URL (1)： https://iamaim.jp/

Research field (2)： Immunology , Pathobiochemistry

Research keywords (4)： CD5L , 炎症収束学 , Restorative macrophage , Apoptosis inhibitor of Macrophage (AIM)

Research theme for competitive and other funds (13)：

2023 - 2026 重症肺感染症における宿主防御応答向上のメカニズム解明
2021 - 2024 炎症性組織レジリエンスと組織障害エントロピーの統合的理解と炎症収束学の創成
2021 - 2024 Elucidation of the roles of restorative macrophages in inflammatory tissue resilience
2020 - 2023 食細胞機構を用いた視機能劣化(アイフレイル)および眼疾患の制御
2018 - 2021 脂肪肝肝癌の発症機序におけるAIMの関連に関する研究

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Papers (57)：

Keisuke Yasuda, Shieri Shimodan, Natsumi Maehara, Aika Hirota, Ruka Iijima, Akemi Nishijima, Haruka Mori, Ran Toyama, Atsumi Ito, Yuri Yoshikawa, et al. AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions. Journal of autoimmunity. 2023. 142. 103149-103149
Hotaka Nemoto, Megumi Honjo, Satoko Arai, Toru Miyazaki, Makoto Aihara. Apoptosis inhibitor of macrophages/CD5L enhances phagocytosis in the trabecular meshwork cells and regulates ocular hypertension. Journal of cellular physiology. 2023. 238. 10. 2451-2467
Michiko Takimoto-Sato, Masaru Suzuki, Hiroki Kimura, Haiyan Ge, Munehiro Matsumoto, Hironi Makita, Satoko Arai, Toru Miyazaki, Masaharu Nishimura, Satoshi Konno. Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD. Respiratory research. 2023. 24. 1. 201-201
Kyohei Matsuura, Natsumi Maehara, Aika Hirota, Ayaka Eguchi, Keisuke Yasuda, Kaori Taniguchi, Akemi Nishijima, Nobuyuki Matsuhashi, Yoshiyuki Shiga, Rumi Ishii, et al. Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1. Communications biology. 2022. 5. 1. 783-783
Natsumi Maehara, Kaori Taniguchi, Ami Okuno, Hideaki Ando, Aika Hirota, Zhiheng Li, Ching-Ting Wang, Satoko Arai, Toru Miyazaki. AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke. Cell reports. 2021. 36. 11. 109693-109693

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MISC (43)：

新井郷子, 宮崎徹. 【心血管病の臓器連関】心血管病におけるマクロファージ由来血中タンパク質AIMのかかわり. 循環器内科. 2022. 92. 6. 642-648
新井郷子, 宮崎徹. 【尿細管と腎線維化】急性腎障害治療薬としてのAIMの展望. 腎と透析. 2022. 93. 6. 912-916
新井郷子, 宮崎徹. 【生物と腎臓】ペットと腎臓病猫の腎不全の治療. 腎臓. 2021. 43. 27-32
新井郷子, 宮崎徹. 【マクロファージの功罪-疾患病態誘導と制御におけるマクロファージの役割】臓器不全動脈硬化とマクロファージ. 医学のあゆみ. 2020. 273. 10. 955-960
新井郷子, 平本絵美莉, 包明久, 吉川雅英, 宮崎徹. IgMは正五角形か? 電子顕微鏡と単粒子解析が解き明かした真実. 糖尿病・内分泌代謝科. 2020. 50. 3. 203-210

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Lectures and oral presentations (11)：

Role of phagocytic mechanisms in inflammatory tissue resilience and its application to disease therapy
(The 96th Annual Meeting of the Japan Biochemical Society 2023)
腎結石症改善に向けた最新知見 -血中タンパク質AIMの結石抑制における新たな役割の発見-
(第14回日本臨床一般検査学会、第20回スキルアップ講習会 2023)
Therapeutic and diagnostic impacts of AIM on refractory chronic diseases
(The 100th Anniversary Annual Meeting of the Physiological Society of Japan 2023)
A role of the phagocytic removal system in resolution of inflammation and its therapeutic implication
(2022)
マクロファージ由来タンパク質AIMのセルフ・パソジェン除去機能を介した炎症収束~急性腎障害から脳梗塞まで~,
(千葉大学リーディング研究育成プログラム「希少・難治性疾患に対する革新的治療創生研究シンポジウム」 2022)

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Education (3)：

2001 - 2004 The University of Tokyo Graduate School of Agricultural and Life Sciences Applied Biological Chemistry
1999 - 2001 The University of Tokyo Graduate School of Agricultural and Life Sciences Applied Biological Chemistry
1997 - 1999 The University of Tokyo

Work history (6)：

2023/04 - 現在 The Institute for AIM Medicine Vice Director
2016/01 - 2023/03 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Associate Professor
2014/07 - 2016/01 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Project Associate Professor
2007/07 - 2014/07 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Lecturer
2005/10 - 2007/07 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Assistant Professor

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Association Membership(s) (3)：

The Japanese Biochemical Society , Japan Society for Immunology , The Molecular Biology Society Japan

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