Rchr
J-GLOBAL ID:201801019570926382   Update date: Oct. 13, 2021

Arai Satoko

新井 郷子 | Arai Satoko
Affiliation and department:
Job title: Associate Professor
Homepage URL  (1): http://tmlab.m.u-tokyo.ac.jp/index.html
Research field  (2): Immunology ,  Pathobiochemistry
Research keywords  (3): 炎症収束学 ,  Restorative macrophage ,  Apoptosis inhibitor of Macrophage (AIM)
Research theme for competitive and other funds  (10):
  • 2020 - 2023 食細胞機構を用いた視機能劣化(アイフレイル)および眼疾患の制御
  • 2018 - 2021 脂肪肝肝癌の発症機序におけるAIMの関連に関する研究
  • 2016 - 2019 Investigation of roles of circulating protein AIM in chronic kidney disease and its therapeutic application
  • 2017 - 2018 Analysis of the effect of inseparable association of AIM with IgM on obesity-related diseases
  • 2014 - 2017 Clarification of the role of CX3CR1/FKN/AIM axis in IgA nephrology
Show all
Papers (49):
  • Natsumi Maehara, Kaori Taniguchi, Ami Okuno, Hideaki Ando, Aika Hirota, Zhiheng Li, Ching-Ting Wang, Satoko Arai, Toru Miyazaki. AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke. Cell reports. 2021. 36. 11. 109693-109693
  • Akiko Takahata, Satoko Arai, Emiri Hiramoto, Kento Kitada, Rina Kato, Yuko Makita, Hitoshi Suzuki, Junichiro Nakata, Kimi Araki, Toru Miyazaki, et al. Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy. Journal of the American Society of Nephrology : JASN. 2020. 31. 9. 2013-2024
  • Ginga Komatsu, Toru Nonomura, Mai Sasaki, Yuki Ishida, Satoko Arai, Toru Miyazaki. AIM-deficient mouse fed a high-trans fat, high-cholesterol diet: a new animal model for nonalcoholic fatty liver disease. Experimental animals. 2019. 68. 2. 147-158
  • Arai S, Miyazaki T. A scavenging system against internal pathogens promoted by the circulating protein apoptosis inhibitor of macrophage (AIM). Seminars in immunopathology. 2018. 40. 6. 567-575
  • Hiramoto E, Tsutsumi A, Suzuki R, Matsuoka S, Arai S, Kikkawa M, Miyazaki T. The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein. Science advances. 2018. 4. 10. eaau1199
more...
MISC (37):
  • 新井 郷子, 宮崎 徹. 【生物と腎臓】ペットと腎臓病 猫の腎不全の治療. 腎臓. 2021. 43. 27-32
  • 新井 郷子, 宮崎 徹. 【マクロファージの功罪-疾患病態誘導と制御におけるマクロファージの役割】臓器不全 動脈硬化とマクロファージ. 医学のあゆみ. 2020. 273. 10. 955-960
  • 新井 郷子, 平本 絵美莉, 包 明久, 吉川 雅英, 宮崎 徹. IgMは正五角形か? 電子顕微鏡と単粒子解析が解き明かした真実. 糖尿病・内分泌代謝科. 2020. 50. 3. 203-210
  • 新井 郷子, 宮崎 徹. 【免疫系を介したシステム連関:恒常性の維持と破綻】免疫と代謝 IgMによる血中タンパク質AIMの活性制御と疾患とのかかわり. 生体の科学. 2019. 70. 2. 148-154
  • 新井 郷子, 宮崎 徹. 血中タンパク質AIMによる体内のスカベンジングシステム. 感染・炎症・免疫. 2017. 47. 2. 98-107
more...
Lectures and oral presentations  (4):
  • 1. マクロファージ由来タンパク質AIMによるがん細胞の除去機構を利用した肝細胞がん治療法の開発
    (JCRP平成29年度市民向け成果発表会 2018)
  • 4. Study on activation of circulating AIM in multiple diseases-from NASH-HCC to acute kindly injury
    (Max Planck-The University of Tokyo Center for Integrative Inflammology Symposium 2017 2017)
  • 3. 血中タンパク質AIMによる異物除去機構を介した疾患の制御
    (第35回内分泌代謝学サマーセミナー 2017)
  • 1. Expression of AIM by large peritoneal macrophages (LPMs) and its role in phagocytic activity
    (Keystone Symposium, Mononuclear Phagocytes in Health, Immune Defense and Disease (D3) 2017)
Education (3):
  • 2001 - 2004 The University of Tokyo Applied Biological Chemistry
  • 1999 - 2001 The University of Tokyo Applied Biological Chemistry
  • 1997 - 1999 The University of Tokyo
Work history (5):
  • 2016/01 - 現在 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Associate Professor
  • 2014/07 - 2016/01 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Project Associate Professor
  • 2007/07 - 2014/07 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Lecturer
  • 2005/10 - 2007/07 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Assistant Professor
  • 2004/04 - 2005/10 University of Texas Southwestern Medical Center at Dallas Center for Immunology Postdoctoral fellow
Association Membership(s) (2):
Japan Society for Immunology ,  The Molecular Biology Society Japan
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