Rchr
J-GLOBAL ID：201801019570926382
Update date: Nov. 20, 2024
Arai Satoko
新井 郷子 | Arai Satoko
Affiliation and department：
Job title：
Chief Scientist, Vice Director
Homepage URL (1)：
https://iamaim.jp/
Research field (2)：
Immunology
, Pathobiochemistry
Research keywords (5)：
Immunoglobulin M (IgM)
, tissue repair
, CD5L
, 炎症収束学
, Restorative macrophage
Research theme for competitive and other funds (13)：
- 2023 - 2026 重症肺感染症における宿主防御応答向上のメカニズム解明
- 2021 - 2024 炎症性組織レジリエンスと組織障害エントロピーの統合的理解と炎症収束学の創成
- 2021 - 2024 Elucidation of the roles of restorative macrophages in inflammatory tissue resilience
- 2020 - 2023 食細胞機構を用いた視機能劣化(アイフレイル)および眼疾患の制御
- 2018 - 2021 脂肪肝肝癌の発症機序におけるAIMの関連に関する研究
- 2016 - 2019 Investigation of roles of circulating protein AIM in chronic kidney disease and its therapeutic application
- 2017 - 2018 Analysis of the effect of inseparable association of AIM with IgM on obesity-related diseases
- 2014 - 2017 Clarification of the role of CX3CR1/FKN/AIM axis in IgA nephrology
- 2013 - 2016 Obesity and liver diseases: towards clarification of mechanisms for NASH
- 2012 - 2015 Development of prophylaxis and therapy system for metabolic stmdorome by regulation of AIM function
- 2010 - 2011 Analysis for hematopoiesis and hematologic diseases by L3MBTL1 conditional knockout mice.
- 2007 - 2008 Analysis of entire roles for AIM in atherosclerogenesis
- 2006 - 2007 新しいポリコーム分子MBT-1による白血病制御を目指して
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Papers (58)：
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Qu Chen, Kazuhiro Ishii, Haruka Mori, Akemi Nishijima, Satoko Arai, Toru Miyazaki, Peter B. Rosenthal. Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M. Nature Communications. 2024
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Keisuke Yasuda, Shieri Shimodan, Natsumi Maehara, Aika Hirota, Ruka Iijima, Akemi Nishijima, Haruka Mori, Ran Toyama, Atsumi Ito, Yuri Yoshikawa, et al. AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions. Journal of autoimmunity. 2023. 142. 103149-103149
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Hotaka Nemoto, Megumi Honjo, Satoko Arai, Toru Miyazaki, Makoto Aihara. Apoptosis inhibitor of macrophages/CD5L enhances phagocytosis in the trabecular meshwork cells and regulates ocular hypertension. Journal of cellular physiology. 2023. 238. 10. 2451-2467
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Michiko Takimoto-Sato, Masaru Suzuki, Hiroki Kimura, Haiyan Ge, Munehiro Matsumoto, Hironi Makita, Satoko Arai, Toru Miyazaki, Masaharu Nishimura, Satoshi Konno. Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD. Respiratory research. 2023. 24. 1. 201-201
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Kyohei Matsuura, Natsumi Maehara, Aika Hirota, Ayaka Eguchi, Keisuke Yasuda, Kaori Taniguchi, Akemi Nishijima, Nobuyuki Matsuhashi, Yoshiyuki Shiga, Rumi Ishii, et al. Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1. Communications biology. 2022. 5. 1. 783-783
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MISC (43)：
Lectures and oral presentations (11)：
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Role of phagocytic mechanisms in inflammatory tissue resilience and its application to disease therapy
(The 96th Annual Meeting of the Japan Biochemical Society 2023)
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腎結石症改善に向けた最新知見 -血中タンパク質AIMの結石抑制における新たな役割の発見-
(第14回日本臨床一般検査学会、第20回スキルアップ講習会 2023)
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Therapeutic and diagnostic impacts of AIM on refractory chronic diseases
(The 100th Anniversary Annual Meeting of the Physiological Society of Japan 2023)
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A role of the phagocytic removal system in resolution of inflammation and its therapeutic implication
(2022)
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マクロファージ由来タンパク質AIMのセルフ・パソジェン除去機能を介した炎症収束~急性腎障害から脳梗塞まで~,
(千葉大学リーディング研究育成プログラム「希少・難治性疾患に対する革新的治療創生研究シンポジウム」 2022)
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Education (3)：
- 2001 - 2004 The University of Tokyo Graduate School of Agricultural and Life Sciences Applied Biological Chemistry
- 1999 - 2001 The University of Tokyo Graduate School of Agricultural and Life Sciences Applied Biological Chemistry
- 1997 - 1999 The University of Tokyo
Work history (6)：
- 2023/04 - 現在 The Insitute for AIM Medicine Department of Molecular Biomedicine for Pathogenesis Chief Scientist, Vice Director
- 2016/01 - 2023/03 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Associate Professor
- 2014/07 - 2016/01 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Project Associate Professor
- 2007/07 - 2014/07 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Lecturer
- 2005/10 - 2007/07 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Assistant Professor
- 2004/04 - 2005/10 University of Texas Southwestern Medical Center at Dallas Center for Immunology Postdoctoral fellow
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Association Membership(s) (3)：
The Japanese Biochemical Society
, Japan Society for Immunology
, The Molecular Biology Society Japan
